排序方式: 共有52条查询结果,搜索用时 15 毫秒
1.
2.
By considering the problems that commercial saffron companies have faced in international markets, the aim of this study is to investigate the impact of website content, including informational and design dimensions, on the effectiveness of e-marketing and e-trust as mediator variables. These aspects are examined with reference to sales and marketing division managers in a sample of 100 commercial saffron corporations in the Khorasan province. The findings support the ideas that website content has an effect on e-marketing and e-trust and that e-trust plays a mediating role in the relationship between e-trust and e-marketing effectiveness. 相似文献
3.
Farshid Hassanzadeh Sahar Maaleki Jaleh Varshosaz Ghadam Ali Khodarahmi Maryam Farzan Mahboubeh Rostami 《Iranian Polymer Journal》2016,25(11):967-976
A novel thermosensitive folic acid (FA)-targeted succinylated poly (ethylene-co-vinyl alcohol) (EVOH) (EVOHS-FA) nanocarrier was synthesized for the specific delivery of epirubicin (EPI) to MCF-7 breast cancer cell line. Three different ratios of synthesized EVOH-Suc were reacted with FA. The structure of the desired products (EVOHS40-FA, EVOHS60-FA and EVOHS80-FA) was confirmed by 1H NMR and FTIR techniques. Nanoparticles were obtained by nano-precipitation procedure using DMSO/H2O as solvent/anti-solvent. The particle size, zeta potential, entrapment efficacy and in vitro release profile of the final formulations in different temperatures were measured. The optimized nanoparticles had the particle size of 214 ± 8.5 nm, zeta potential of ?29.6 mV, PDI of 0.198 ± 0.04, and a high encapsulation efficiency that released the drug efficiently within 450 h at the temperature of 40 °C compared to 37 °C. The morphology of nanoparticles was studied by scanning electron microscopy. The in vitro cytotoxicity was evaluated using the MTT assay on MCF-7 cell lines in response to temperatures of 37 and 40 °C. The MTT assay indicated that the targeted nanoparticles carrying EPI were significantly more cytotoxic than the non-targeted nanoparticles and the free drug at 40 °C. 相似文献
4.
Zahra Bakhtiary Jaleh Barar Ayuob Aghanejad Amir Ata Saei Elhameh Nemati 《Drug development and industrial pharmacy》2017,43(8):1244-1253
Non-small cell lung cancer (NSCLC) patients with sensitizing mutations in the exons 18–21 of the epithelial growth factor receptor (EGFR) gene show increased kinase activity of EGFR. Hence, tyrosine kinase inhibitors (TKIs) such as erlotinib (ETB) have commonly been used as the second line therapeutic option for the treatment of metastatic NSCLC. While the ETB is available as an oral dosage form, the local delivery of this TKI to the diseased cells of the lung may ameliorate its therapeutic impacts. In the current study, we report on the development of ETB-loaded solid lipid nanoparticle (SLN) based formulation of dry powder inhaler (ETB-SLN DPI). ETB-SLNs were formulated using designated amount of compritol/poloxamer 407. The engineered ETB-SLNs showed sub-100?nm spherical shape with an encapsulation efficiency of 78.21%. MTT assay and DAPI staining revealed that the ETB-SLNs enhanced the cytotoxicity of cargo drug molecules in the human alveolar adenocarcinoma epithelial A549 cells as a model for NSCLC. To attain the ETB-SLN DPI, the ETB-SLNs were efficiently spray dried into microparticles (1–5?μm) along with mannitol. The ETB-SLN DPI powder displayed suitable flowability and aerodynamic traits. The Carr's Index, Hausner ratio and Next Generation Impactor (NGI) analyses confirmed deep inhalation pattern of the formulation. Based on these findings, we propose the ETB-SLN DPI as a promising treatment modality for the NSCLC patients. 相似文献
5.
Various lines of atomic fluorine laser have been studied over a wide pressure range for determination of the relative intensity of each pressure-dependent line. In this investigation, the most probable laser pumping mechanisms have been verified. 相似文献
6.
Jaleh Mansouri Chris A. Wood Katherine Roberts Yi-Bing Cheng Robert P. Burford 《Journal of Materials Science》2007,42(15):6046-6055
Glass frits were added into silicone-based composites with the aim to improve low temperature ceramification at elevated temperatures.
The effect of glass frits on the properties of ceramic residue is investigated. Field emission scanning electron microscopy
(FESEM), electron probe microchemical analysis (EPMA) and X-ray diffraction analysis (XRD) showed that glass frits reacted
via a eutectic reaction with mica and silica. Electrical conductivity measurements at elevated temperatures showed a decline
in volume resistivity with glass frit addition. It was concluded that increased conductivity is a result of ionic conduction
of the glass phase produced by eutectic reactions between frits, silica and mica at high temperatures. Thermal mechanical
analysis (TMA) was used to explore the dimensional changes of these composites during programmed heat treatment. 相似文献
7.
B. Jaleh M. Valieghbal S. Habibi M. J. Torkamany 《Journal of Superconductivity and Novel Magnetism》2012,25(8):2665-2669
Amorphous metallic alloys (AMAS) have found wide application in various fields. Laser is used to modify materials. In this work, we have prepared an amorphous metallic alloy with composition Fe77Co21Si2 using the melt spinning method. The prepared specimens have irradiated by a Nd:YAG laser at 1064?nm, with various fluences to investigate the corresponding induced change. The structures of specimens are verified by X-ray diffraction (XRD) before and after laser irradiated. Then magnetic parameters are measured using a vibrating sample magnetometer. Morphology reference and laser treated samples are investigated by the scanning electron microscope (SEM). The use of laser beam of relatively low energy, but with a subsequent overlapping of heated areas, resulted in a much more homogeneous structure in the heated areas of the ribbon. These measurements show that initially the magnetic properties are altered due to laser processing. The surface alteration was being simultaneously monitored by laser induced breakdown spectroscopy (LIBS). 相似文献
8.
Sana Pirmardvand Chegini Jaleh Varshosaz Hamid Mirmohammad Sadeghi Alireza Dehghani Mohsen Minayian 《IET nanobiotechnology / IET》2019,13(9):974
Poly(glycerol sebacate) (PGS) is a new biodegradable polymer with good biocompatibility used in many fields of biomedicine and drug delivery. Sunitinib‐loaded PGS/gelatine nanoparticles were prepared by the de‐solvation method for retinal delivery and treatment of diabetic retinopathy. The nanoparticles were characterised by Fourier‐transform infrared and differential scanning calorimetry. The effects of different formulation variables including drug‐to‐carrier ratio, gelatine‐to‐PGS ratio, and glycerine‐to‐sebacate ratio were assessed on the encapsulation efficiency (EE%), particle size, release efficiency (RE), and zeta potential of the nanoparticles. The in vitro cytotoxicity of PGS/gelatine nanoparticles was studied on L929 cells. Draize test on rabbit eyes was also done to investigate the possible allergic reactions caused by the polymer. Glycerine/sebacic acid was the most effective parameter on the EE and RE. Gelatine‐to‐PGS ratio had the most considerable effect on the particle size while the RE was more affected by the glycerine/sebacic acid ratio. The optimised formulation (S1 G0.7 D21.2) exhibited a particle size of 282 nm, 34.6% EE, zeta potential of −8.9 mV, and RE% of about 27.3% for drug over 228 h. The 3‐(4,5‐dimethylthuazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide assay indicated PGS/gelatine nanoparticles were not cytotoxic and sunitinib‐loaded nanoparticles were not toxic at concentrations <36 nM.Inspec keywords: polymers, differential scanning calorimetry, toxicology, drug delivery systems, solvation, eye, encapsulation, particle size, drugs, biodegradable materials, nanofabrication, nanomedicine, nanoparticles, gelatin, Fourier transform infrared spectraOther keywords: gelatine‐to‐PGS ratio, glycerine‐to‐sebacate ratio, particle size, zeta potential, sunitinib‐loaded nanoparticles, biodegradable polymer, retinal delivery, differential scanning calorimetry, drug‐to‐carrier ratio, allergic reactions, physicochemistry, cytotoxicity, poly(glycerol sebacate) nanoparticles, sunitinib ocular delivery, drug delivery, sunitinib‐loaded PGS‐gelatine nanoparticles, Fourier‐transform, in vitro cytotoxicity, biocompatibility, Draize test, rabbit eyes, 3‐(4,5‐dimethylthuazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide assay 相似文献
9.
Nasrollahzadeh Mahmoud Shafiei Nasrin Eslamipanah Mahtab Fakhri Parisa Jaleh Babak Orooji Yasin Varma Rajender S. 《Clean Technologies and Environmental Policy》2020,22(8):1715-1724
Clean Technologies and Environmental Policy - This work reports the fabrication of Au nanoparticles (NPs) by laser ablation of a gold metal plate immersed in water in the absence of stabilizing... 相似文献
10.
Jaleh Babak Gandomi Rouzbahani Mastaneh Abedi Kamaladdin Azizian Saeid Ebrahimi Hossein Nasrollahzadeh Mahmoud Varma Rajender S. 《Clean Technologies and Environmental Policy》2019,21(6):1259-1268
Clean Technologies and Environmental Policy - In this study, TiO2 nanoparticles (NPs)-based catalysts were prepared for the photocatalytic removal of toluene as a model VOC from air under UV light.... 相似文献