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1.
EH Jeffery K Abreo E Burgess J Cannata JL Greger 《Canadian Metallurgical Quarterly》1996,48(6):649-665
Although the full mechanisms are not yet elucidated, research into the mechanism of toxicity of aluminum (Al) on bone formation and remodeling and on hematopoietic tissue is ongoing. In contrast little information exists on the interactive effects of systemic Al and the kidney. In bone, both clinically and experimentally, high doses of Al inhibit remodeling, slowing both osteoblast and osteoclast activities and producing osteomalacia and adynamic bone disease. In contrast, while very low levels of Al are mitogenic in bones of experimental animals, the effect of low levels of Al in humans is unknown. Aluminum has been shown to have its mitogenic action at the osteoblast, but whether the effect on resorption is viz osteoblast-directed changes in osteoclast activity has not yet been determined. Parathyroid hormone (PTH) levels are disrupted by Al in humans and animals. Whether altered PTH levels play a major or even a minor role in Al-dependent osteotoxicity requires clarification. In hematopoietic tissue, Al causes a microcytic anemia, not reversible by iron. Friend leukemia cells treated with Al have been reported to accumulate excess iron, without incorporating it into ferritin or heme. It is not yet known which steps in iron metabolism are disrupted by Al, if they involve a single mechanism of action, or even if this disruption in iron metabolism accounts for the anemia seen in Al toxicosis. In kidney, research is needed to evaluate Al nephrotoxicity; there are almost no studies in this area. Furthermore, research is needed to evaluate mechanisms of renal Al excretion, presently shown by one study to occur at the distal tubule. Such studies might well throw light on whether Al plays a role in aggravating renal insufficiency, or whether the role of the kidney in Al toxicosis is limited to the causative effect of renal compromise on Al accumulation. In summary, while a number of mechanisms have been proposed for the toxic action of Al, no single mechanism emerges to explain these diverse effects of systemic Al. Recommendations for future research are presented and summarized in Table 1. 相似文献
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D. B. Zeik J. R. Dugan D. W. Schroeder J. W. Baur S. J. Clarson G. N. De Brabander J. T. Boyd 《应用聚合物科学杂志》1995,56(9):1039-1044
Plasma-polymerized hexamethyldisiloxane (HMDS) films have been prepared as both planar and channel wave guides. The optical attenuation results measured in both the planar and channel HMDS wave guides were found to be similar, thus demonstrating that the inherent solvent resistance and chemical inertness of the plasma polymerized films allows the use of common photoresist techniques, including application of the photoresist, photomasking, and subsequent etching. This may be contrasted with wave guides made from conventional polymers, where careful consideration must be given to photoresist/polymer compatibility, because the photoresist solvents may adversely affect the underlying polymer and lead to degradation of the material during processing. © 1995 John Wiley & Sons, Inc. 相似文献
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Plasmid deoxyribonucleic acid of group N streptococci codes for a wide variety of important metabolic properties associated with dairy fermentations. The increasing knowledge of the genetics of these bacteria has created exciting possibilities for genetically constructing improved starter strains. A review of current literature is presented on the genetics of group N streptococci, especially the development and implications of gene transfer and molecular cloning systems for further genetic studies and for strain improvement. Functional properties of plasmid deoxyribonucleic acid and gene transfer systems, which include transduction, conjugation, transformation, and protoplast fusion, are reviewed and followed by a discussion of recent advances in gene cloning. 相似文献
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Forster Jean L.; Jeffery Robert W.; Schmid Thomas L.; Kramer F. Matthew 《Canadian Metallurgical Quarterly》1988,7(6):515
Evaluated the feasibility and effectiveness of a program for weight gain prevention (WGP) in normal adults. 219 Ss were randomized to either WGP treatment or no treatment for 12 mo. The treatment group received monthly newsletters relating to weight management, participated in a financial incentive system, and were offered an optional 4-session education course in the 6th mo of the program. Results demonstrate high interest in WGP among Ss who were not objectively overweight. Participation, as measured by return of postcards sent with each newsletter, was approximately 75%. Results after 1 yr show a net weight loss of 1.8 lb in the group receiving the program compared with controls. 82% of participants maintained or lost weight, compared with 56% of controls. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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The United States has historically excelled in the design of products, processes and new technologies. Capitalizing on this historical strength to teach applied mathematics and science has many positive implications on education. First, engineering design can be used as a vehicle for addressing deficiencies in mathematics and science education. Second, as achievement in mathematics and science is enhanced, a greater number of students at an earlier age will be exposed to technical career opportunities. Third, enhancing elementary and secondary curricula with engineering design can attract underrepresented populations, such as minorities and females, to engineering as a profession. This paper describes a new and innovative engineering design curriculum, under development in the Austin Independent School District (AISD) in Austin, TX. The philosophic goals upon which the curriculum is based include: integrating the design problem-solving process into elementary schools, demonstrating the relationship of technical concepts to daily life, availing teachers with instructional strategies for teaching applied (as opposed to purely theoretical) science and mathematics, and teaching teamwork skills that are so greatly needed in industry and everyday life. Based on these goals, kindergarten, first grade, and second grade engineering design lessons have been piloted in AISD, in conjunction with a University of Texas program for teacher enhancement and preparation. 相似文献