Enhanced photoelectric properties of PbSnSe thin films via quick oxygen ion-implantation sensitization

Journal of Materials Science - Although chalcogenide materials continue to generate considerable interest due to great potentials for various optoelectronic devices, annealing for a long time in...     

多孔陶瓷的制备和性能研究

选用普通陶瓷原料粉为主要原料，适当添加造孔剂(有机细粉碳黑)和高温活性剂，制备出一种性能优良的多孔陶瓷。通过扫描电镜及性能测试分析，探讨了多孔陶瓷的微观结构及性能的影响因数。     

Engineering a pharmacologically superior form of leptin for the treatment of obesity

Leptin plays a central role in the homeostasis of body weight through its regulatory effects on appetite and energy expenditure, yet in trials as a therapeutic agent for the treatment of obesity in humans it has been disappointing. The poor clinical efficacy of leptin results from its short circulating half-life, low potency and poor solubility, necessitating large and frequent doses to obtain even modest clinical benefit. Engineered Fc-leptin immunofusins, consisting of the Fc fragment of an immunoglobulin gamma chain followed by leptin, exhibit improved pharmacological properties with very consistent and potent biological activities. Furthermore, in extending the circulating half-life of the protein in vivo from a few minutes for leptin to many hours for Fc-leptin, these proteins have the potential to reduce drastically the dosage and frequency of administration required to obtain clinical benefit. The results of this study show that the engineered leptin immunofusins described here have significantly enhanced pharmacological properties in comparison with the recombinant leptin that was used in clinical trials. As such, they could represent an important step towards a therapeutically superior form of leptin if the disappointing performance of leptin in early clinical trials was due to its poor pharmacological properties rather than any conceptual weakness in the strategy of using leptin for the treatment of obesity and its related disorders.     

新型高压密封装置的优化设计

以最低制造成本为优化目标，建立了新型高压密封装置优化设计的数学模型，并给出设计实例。结果表明，采用优化设计可降低制造成本１４．７％。     

纳米结构催化剂的研究和应用

介绍了纳米微孔和纳米结晶物质作催化剂的制备和应用概况，模板合成和溶胶－凝胶湿法合成是很有前景的纳米结构催化剂的制备方法。     

基于整体-局部高阶剪切理论的层合板多体系统的动静力学分析

基于高阶剪切理论,推导了整体-局部1,2-3高阶位移模式.在满足层间位移连续,层间剪应力连续,以及上下表面自由的条件下,层合板每个节点的独立变量变为13,并且不随层合板层数的增加而变化.在此基础上将整体-局部1,2-3高阶位移模式推广到刚-柔耦合层合板多体系统,利用混合坐标法,基于虚功原理,建立了考虑层合板层间应力连续的多体系统动力学方程.通过静力学算例,验证了整体-局部1,2-3高阶位移模式的准确性,得到了层合板层间应力沿着厚度的分布情况.通过多体系统动力学算例,对比了传统方法的计算结果,揭示了本文方法与传统方法在计算层合板多体系统中层间应力的差异,说明了刚-柔耦合层合板多体系统考虑层间剪应力连续的必要性.     

水利工程竣工验收检测评价体系构建

通过调查分析全国有代表性的水利工程质量检测和竣工验收检测的技术资料,以及对工程建 设行业已有检测技术标准的对比分析和研究,提出了水利工程竣工验收检测分部和检测单元的划分、 检测项目和抽样数量、检测技术和评价方法,以及检测评价体系的构成,为制定水利工程质量验收检 测评价技术标准提供技术支持。     

基于Khatri-Rao积的三维前视声呐空间方位估计技术

为了提高3维前视声呐的方位分辨能力,同时避免2维(2D)方位估计(DOA)方法失效,该文提出1维(1D)空间角估计方法、基于Vernier法的垂直角估计方法和基于最小角定理的水平角方位估计方法.首先基于不同子阵构造互协方差矩阵避免2维方位估计模型失效,再利用Khatri-Rao积进行虚拟孔径扩展;将扩展后的阵列导向矢量和观测向量模型用于2维方位估计.与原阵列的导向矢量相比,虚拟阵元数量约增加1倍,阵列的孔径得到有效扩展.仿真实验表明,与单观测向量波束形成2维方位估计方法相比,所提方法在2维方位估计问题中具有更高的分辨能力,均方根误差更低;水池实验进一步验证了该文所提方法的工程实用性.     

基于R-tree的高效异常轨迹检测算法

异常检测是一种流行的数据挖掘任务,但是轨迹数据的异常检测的研究比较少,而且存在的算法也较有局限性,因此J.-G Lee等人提出了TRAOD算法。该算法能够有效地检测出异常的轨迹,但是也存在着缺陷。它的复杂度和准确度比较难平衡,在参数的选取上也比较难,算法的运行时间较长。基于TRAOD的问题,提出一种基于R-tree的高效的异常轨迹检测算法R-TRAOD。该算法通过R-tree对轨迹点进行索引搜索其领域内的轨迹点,然后根据TRAOD算法对R-tree索引出来的轨迹点进行异常轨迹的检测,这样可以提高算法的运行速度。真实数据实验测试表明,该算法比最新的TRAOD异常轨迹挖掘算法效率要高。