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1.
Sea lice threaten the welfare of farmed Atlantic salmon and the sustainability of fish farming across the world. Chemical treatments are the major method of control but drug resistance means that alternatives are urgently needed. Selective breeding can be a cheap and effective alternative. Here, we combine experimental trials and diagnostics to provide a practical protocol for quantifying resistance to sea lice. We then combined quantitative genetics with epidemiological modelling to make the first prediction of the response to selection, quantified in terms of reduced need for chemical treatments. We infected over 1400 young fish with Lepeophtheirus salmonis, the most important species in the Northern Hemisphere. Mechanisms of resistance were expressed early in infection. Consequently, the number of lice per fish and the ranking of families were very similar at 7 and 17 days post infection, providing a stable window for assessing susceptibility to infection. The heritability of lice numbers within this time window was moderately high at 0.3, confirming that selective breeding is viable. We combined an epidemiological model of sea lice infection and control on a salmon farm with genetic variation in susceptibility among individuals. We simulated 10 generations of selective breeding and examined the frequency of treatments needed to control infection. Our model predicted that substantially fewer chemical treatments are needed to control lice outbreaks in selected populations and chemical treatment could be unnecessary after 10 generations of selection. Selective breeding for sea lice resistance should reduce the impact of sea lice on fish health and thus substantially improve the sustainability of Atlantic salmon production.  相似文献   
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Theoretical and experimetal methods have been developed to characterize the effect of mechanical loading on the mesoscopic and macroscopic mechanical state of polycrystalline materials. Ferritic and austenitic single-phase materials were first analyzed, then phase interaction was studied in a multiductile phase material (austeno-ferritic duplex steel) and a natural reinforced composite (pearlitic steel). The theoretical method is based on the self-consistent approach in which elastic and plastic characteristics of the phases have been applied through the micromechanical behavior of single-crystal-using slip systems and microscopic hardening. The effects of a crystallographic texture and phase interaction during loading and after unloading were studied. The elastic and plastic anisotropy of the grains having the same crystallographic orientation were assessed by diffraction strain analysis. The simulation was compared with the experiments performed using the X-ray diffraction technique. In the considered duplex and pearlitic steels, it was observed that the ferrite stress state is much lower than the austenite and cementite ones. The results of diffraction strain distribution have showed the pertinence of the models and give valuable information, for example, for the yield stress and the hardening parameters of each phase in a two-phase material.  相似文献   
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The accumulation of two independent, broadly applicable formulations for determining the boundary to manipulator workspaces, presented elsewhere, are compared in this paper. Insights gained from one method are used to explain behavior exhibited in the other. Results are also compared and validated. A numerical formulation based on continuation methods is used to map curves that are on the boundary of a manipulator workspace. Analytical criteria based on row rank deficiency criteria of the manipulator's analytical Jacobian are used to map a family of one-dimensional solution curves on the boundary. The other formulation, based on a similar rank-deficiency criteria, yields analytic boundaries parametrized in terms of surface patches on the boundary. Results concerning the applicability of the numerical method to open- and closed-loop systems are compared with those limited to the open-loop for the analytical method. Conclusions regarding the behavior of the manipulator on geometric entities characterized by singular curves, higher-order bifurcation points, and surfaces inside the workspace are drawn. Applicability of both methods and their limitations are also addressed.  相似文献   
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Several ternary alloys were designed to help understand the type of substitution and the nature of transformation in L12-type ternary (Fe or Ni) titanium aluminides. X-ray powder diffraction analysis, scanning electron microscopy and microhardness measurements were used to delineate the phases present in arc-melted alloys that were annealed at 1300 K for 10 days. The results of this study show that, in L12 type ternary (Fe, Ni) titanium aluminides, Fe or Ni substitutes for Ti, and these materials are TiAl2-based, contrary to previous assumptions.  相似文献   
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The sinuous antennas have a numerous applications in military and civil systems such as direction finding systems and reflector feeds due to their superior broadband characteristics and simultaneous polarization capability. In this paper, design, construction and measurements of planar sinuous antennas are investigated for 1–5 GHz frequency range. Feeding sections of this antenna are realized by using microstrip tapered baluns. We have determined the microstrip tapered balun dimensions using Ansoft HFSS-simulation program. The performances of the manufactured antenna are measured using HP vector network analyzer. Polarization patterns and return loss characteristics of the designed antenna that have been measured in anechoic chamber, are presented.  相似文献   
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Plasmas in the Levitated Dipole Experiment (LDX) are formed and sustained currently via two electron cyclotron resonance heating (ECRH) sources: 2.5 kW at 2.45 GHz and 2.5 kW at 6.4 GHz. An important topic being investigated is how varying the ECRH affects the confinement and stability of the plasma. We report the results of using different operational combinations of our RF sources, such as varying the power composition, changing the power levels, and sequencing of the onset time.  相似文献   
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Ohne Zusammenfassung  相似文献   
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Hybrid predictive dynamics: a new approach to simulate human motion   总被引:1,自引:0,他引:1  
A new methodology, called hybrid predictive dynamics (HPD), is introduced in this work to simulate human motion. HPD is defined as an optimization-based motion prediction approach in which the joint angle control points are unknowns in the equations of motion. Some of these control points are bounded by the experimental data. The joint torque and ground reaction forces are calculated by an inverse algorithm in the optimization procedure. Therefore, the proposed method is able to incorporate motion capture data into the formulation to predict natural and subject-specific human motions. Hybrid predictive dynamics includes three procedures, and each is a sub-optimization problem. First, the motion capture data are transferred from Cartesian space into joint space by using optimization-based inverse kinematics (IK) methodology. Secondly, joint profiles obtained from IK are interpolated by B-spline control points by using an error-minimization algorithm. Third, boundaries are built on the control points to represent specific joint profiles from experiments, and these boundaries are used to guide the predicted human motion. To predict more accurate motion, the boundaries can also be built on the kinetic variables if the experimental data are available. The efficiency of the method is demonstrated by simulating a box-lifting motion. The proposed method takes advantage of both prediction and tracking capabilities simultaneously, so that HPD has more applications in human motion prediction, especially towards clinical applications.  相似文献   
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