Treatment of Stress Urinary Incontinence with Muscle Stem Cells and Stem Cell Components: Chances,Challenges and Future Prospects

Urinary incontinence (UI) is a major problem in health care and more than 400 million people worldwide suffer from involuntary loss of urine. With an increase in the aging population, UI is likely to become even more prominent over the next decades and the economic burden is substantial. Among the different subtypes of UI, stress urinary incontinence (SUI) is the most prevalent and focus of this review. The main underlying causes for SUI are pregnancy and childbirth, accidents with direct trauma to the pelvis or medical treatments that affect the pelvic floor, such as surgery or irradiation. Conservative approaches for the treatment of SUI are pelvic physiotherapy, behavioral and lifestyle changes, and the use of pessaries. Current surgical treatment options include slings, colposuspensions, bulking agents and artificial urinary sphincters. These treatments have limitations with effectiveness and bear the risk of long-term side effects. Furthermore, surgical options do not treat the underlying pathophysiological causes of SUI. Thus, there is an urgent need for alternative treatments, which are effective, minimally invasive and have only a limited risk for adverse effects. Regenerative medicine is an emerging field, focusing on the repair, replacement or regeneration of human tissues and organs using precursor cells and their components. This article critically reviews recent advances in the therapeutic strategies for the management of SUI and outlines future possibilities and challenges.     

PI control based on fuzzy set-point weighting tracking for hydraulic crane boom system

A PI control strategy based on fuzzy set-point weighting following was proposed for the active damping control of a hydraulic crane boom system （HCBS）. Two valve-controlled PI controllers, which include a proportional feedforward controller based on fuzzy set-point weighting following and a limited semi-integrator（LSI）, are designed respectively. LSI is used to limit output signal and to prevent wind up at the low frequency of the spectrum. By using a range camera and an electronic feedback control, the tip damping on the HCBS can be adjusted artificially. A collaborative control simulation technique of HOPSAN and MATLAB/SIMULINK is applied to the controller design. Simulation results show that the proposed PI control system has less overshoot as well as faster response. The tip damping on the HCBS during operation is improved.     

A general scheme for spectral efficiency evaluation ofdirect-sequence spread-spectrum systems

Typically, spectral efficiency, the throughput in bits/second/hertz, has been evaluated for fixed values of the bit error probability. We introduce a cutoff-rate-based approach to evaluation of the spectral efficiency of direct-sequence spread-spectrum schemes so that the results are independent of specific bit error rates or channel codes. Results are shown for M-ary phase-shift keyed modulation on the slow-fading Rician channel     

Time stepping finite element analysis of a variable speed synchronous generator with rectifier

Several applications for renewable energy conversion make use of variable speed generators. A conversion from variable frequency to grid frequency is therefore essential. One part of the converter is a rectifier. A rectifier model is presented, which is integrated in a time stepping finite element simulation environment where the generator and circuit equations are solved simultaneously. The model handles bidirectional alternator speeds as the application is a linear generator for ocean wave energy conversion. The rectifier model is extended with a load model, consisting of R, L and E, and simulations show what impact the rectifier has on the generator’s behaviour.     

Crystal structure of a complex of Escherichia coli glycerol kinase and an allosteric effector fructose 1,6-bisphosphate

The three-dimensional structures of Escherichia coli glycerol kinase (GK) with bound glycerol in the presence and absence of one of the allosteric regulators of its activity, fructose 1,6-bisphosphate (FBP), at 3.2 and 3.0 A, are presented. The molecule crystallized in space group P41212, and the structure was solved by molecular replacement. The models were refined with good stereochemistry to final R-factors of 21.1 and 21.9%, respectively. A tetrameric arrangement of monomers was observed which was essentially identical to the proposed inactive tetramer II previously described [Feese, M. D., Faber, H. R., Bystrom, C. E., Pettigrew, D. W., and Remington, S. J. (1998) Structure (in press)]. However, the crystal packing in this form was especially open, permitting the FBP binding site to be occupied and identified. The crystallographic data revealed a most unusual type of FBP binding site formed between two glycine-arginine loops (residues 234-236) where one-half of the binding site is donated by each monomer at the regulatory interface. The molecule of FBP binds in two mutually exclusive modes on a noncrystallographic 2-fold axis at 50% occupancy each; thus, a tetramer of GK binds two molecules of FBP. Ionic interactions between the 1- and 6-phosphates of FBP and Arg 236 were observed in addition to hydrogen bonding interactions between the backbone amide of Gly 234 and the 6-phosphate. No contacts between the protein and the furanose ring were observed. Mutagenesis of Arg 236 to alanine drastically reduced the extent of inhibition of GK by FBP and lowered, but did not eliminate, the ability of FBP to promote tetramer association. These observations are consistent with the previously characterized mechanism of FBP inhibition of GK, in which FBP acts both to promote dimer-tetramer assembly and to inactivate the tetramers.     

The chordlet transform with an application to shape compression

Due to their abilities to succinctly capture features at different scales and directions, wavelet-based decomposition or representation methods have found wide use in image analysis, restoration, and compression. While there has been a drive to increase the representation ability of these methods via directional filters or elongated basis functions, they still have been focused on essentially piecewise linear representation of curves in images. We propose to extend the line-based dictionary of the beamlet framework to one that includes sets of arcs that are quantized in height. The proposed chordlet dictionary has elements that are constrained at their endpoints and limited in curvature by system rate or distortion constraints. This provides a more visually natural representation of curves in images and, furthermore, it is shown that for a class of images the chordlet representation is more efficient than the beamlet representation under tight distortion constraints. A data structure, the fat quadtree and an algorithm for determining an optimal chordlet representation of an image are proposed. Codecs have been implemented to illustrate applications to both lossy and lossless low bitrate compressions of binary edge images, and better rate or rate–distortion performance over the JBIG2 standard and a beamlet-based compression method are demonstrated.     

High levels of glycoalkaloids in the established swedish potato variety magnum bonum

In 1986, potentially toxic levels of the glycoalkaloids α-solanine and α-chaconine were unexpectedly found in tubers of the established Swedish consumer potato variety Magnum Bonum, leading to the imposition of a conditional sales ban on such potatoes. The combined amounts of α-solanine and α-chaconine in more than 300 commercial lots of Magnum Bonum potatoes analysed as a consequence of the ban ranged from 61 to 665 mg kg^?1 fresh weight with an average of 254 mg kg^?1. Sixty-six percent of the samples exceeded a temporary maximum residue limit of 200 mg kg^?1, 8% were above 400 mg kg^?1. Peeling did not significantly remove the glycoalkaloids in tubers with a high content. The occasional glycoalkaloid elevation was initially attributed to the unusually cold and rainy conditions during the late part of the season in 1986, but subsequent investigations have failed to confirm this hypothesis. Varietal characteristics are likely to have been involved since most other common Swedish varieties seemed to have had normal glycoalkaloid levels in 1986. There were no indications of serious or widespread adverse health effects in consumers due to the high glycoalkaloid levels, although there was circumstantial evidence that a few cases of temporary gastrointestinal disturbances were caused by consumption of Magnum Bonum potatoes with glycoalkaloid concentrations in the range 310–1000 mg kg^?1.     

Combined source-channel coding schemes for video transmission overan additive white Gaussian noise channel

There has been an increased interest in the transmission of digital video over real-world transmission media, such as the direct broadcast satellite (DBS) channel. Video transmitted over such a channel is subject to degradation due, in part, to additive white Gaussian noise (AWGN). Some form of forward error-control (FEC) coding may be applied in order to reduce the effect of the noise on the transmitted bitstream; however, determination of the appropriate level of FEC coding is generally an unwieldy and computationally intensive problem, as it may depend upon a variety of parameters such as the type of video, the available bandwidth, and the channel SNR. More specifically, a combined source-channel coding approach is necessary in optimally allocating rate between source and channel coding subject to a fixed constraint on overall transmission bandwidth. In this paper we develop a method of optimal bit allocation under the assumption that the distortion is additive and independent on a frame-by-frame basis. A set of universal operational distortion-rate characteristics is developed which balances the tradeoff between source coding accuracy and channel error protection for a fixed overall transmission rate and provides the basis for the optimal bit allocation approach. The results for specific source and channel coding schemes show marked improvement over suboptimum choices of channel error protection. In addition, we show that our results approach information-theoretic performance bounds which are developed in this work     

Feedback–Feedforward Scheduling of Control Tasks

A scheduling architecture for real-time control tasks is proposed. The scheduler uses feedback from execution-time measurements and feedforward from workload changes to adjust the sampling periods of the control tasks so that the combined performance of the controllers is optimized. The performance of each controller is described by a cost function. Based on the solution to the optimal resource allocation problem, explicit solutions are derived for linear and quadratic approximations of the cost functions. It is shown that a linear rescaling of the nominal sampling frequencies is optimal for both of these approximations. An extensive inverted pendulum example is presented, where the performance obtained with open-loop, feedback, combined feedback and feedforward scheduling, and earliest-deadline first scheduling are compared. The performance under earliest-deadline first scheduling is explained by studying the behavior of periodic tasks under overload conditions. It is shown that the average values of the sampling periods equal the nominal periods, rescaled by the processor utilization.     

Real Time Scheduling Theory: A Historical Perspective

In this 25th year anniversary paper for the IEEE Real Time Systems Symposium, we review the key results in real-time scheduling theory and the historical events that led to the establishment of the current real-time computing infrastructure. We conclude this paper by looking at the challenges ahead of us.