Role of Metabolism in Bone Development and Homeostasis

Carbohydrates, fats, and proteins are the underlying energy sources for animals and are catabolized through specific biochemical cascades involving numerous enzymes. The catabolites and metabolites in these metabolic pathways are crucial for many cellular functions; therefore, an imbalance and/or dysregulation of these pathways causes cellular dysfunction, resulting in various metabolic diseases. Bone, a highly mineralized organ that serves as a skeleton of the body, undergoes continuous active turnover, which is required for the maintenance of healthy bony components through the deposition and resorption of bone matrix and minerals. This highly coordinated event is regulated throughout life by bone cells such as osteoblasts, osteoclasts, and osteocytes, and requires synchronized activities from different metabolic pathways. Here, we aim to provide a comprehensive review of the cellular metabolism involved in bone development and homeostasis, as revealed by mouse genetic studies.     

Dynamical Properties of Vortices in a Bose-Einstein Condensate in a Rotating Lattice

We present simulation results of the vortex dynamics in a trapped Bose-Einstein condensate in the presence of a rotating optical lattice. Changing the potential amplitude and the relative rotation frequency between the condensate and the optical lattice, we find a rich variety of dynamical phases of vortices. In particular, when the optical lattice rotates faster than the condensate, the competition between the pinning force and the interactions by nucleated interstitial vortices leads to the melting of vortex lattice, yielding a vortex liquid phase.     

Identification of stress-induced leakage current components and thecorresponding trap models in SiO2 films [MOStransistors]

Time-decay stress-induced leakage current (SILC) has been systematically investigated for the cases of both Fowler-Nordheim (FN) stress and substrate hot-hole stress. From the three viewpoints of the reproducibility of the current component for the gate voltage scan, the change of oxide charge during the gate voltage scan, and the resistance of the current component to thermal annealing, it has been found that time-decay stress-induced leakage current is composed of five current components, regardless of stress type. Trap models corresponding to each current component have been proposed. In addition, it has also been proven that holes generate the electron traps related to one of those current components     

Superconductivity in SrTa2S5

A strontium tantalum sulfide, SrTa₂S₅, has a hexagonal structure with lattice constants of a =3.32 and c=24.1 Å. With decreasing temperature the electrical resistivity decreases monotonically and exhibits an abrupt superconducting transition at 3.16 K (midpoint). The diamagnetic susceptibility is observed below T_c. The magnetic susceptibility is nearly independent of temperature above T_c and shows Pauli paramagnetism.     

Analytic Approximation to The Standard Error of Swap-Rate

When we select No students from N applicants on the basis of a composite score of subtests, it is important to evaluate the contribution of each subtest. The swap-rate, which is defined as the proportion of the applicants who actually pass the examination but would fail if the j-th subtest were not included in the component to rank the applicants, is one of the measures of the contribution of the j-th subtest.

In this article, first, we derive the characteristics and limiting properties of the population swap-rate. Next, using the properties of the order statistics and the extended hypergeometric distribution, we derive an approximation to the asymptotic variance of the sample swap-rate when the number of applicants is large. Finally, we propose the use of our analytic approximation to the variance of the sample swap-rate in the real data problem and show that it is very efficient.

     

Development of 170 GHz/500 kW gyrotron

A development of 170GHz/500kW level gyrotron was carried out as R&D work of ITER. The oscillation mode is TE_31,8. In a short pulse experiment, the maximum power of 750kW was achieved at 85kV/40A. The efficiency was 22%. In the depressed collector operation, 500kW/36%/50ms was obtained. The maximum efficiency of 40% was obtained at P_RF=470kW whereas the power decrease by the electron trapping was observed. Pulse extension was done up to 10s at P_RF=170kW with the depressed collector operation. The power was limited by the temperature increase of the output window.     

Design optimization of tall tubular lead/acid cells based on an analysis of the reaction distribution

In order to estimate the discharge performance of tall lead/acid cells (with tubular positives), changes in current and potential distributions with discharge progress were calculated with a computer on the basis of plate resistance and the current—potential—time relationship between small facing parts of positive and negative plates. The taller the cell, the larger the voltage drop along the plates. Thus, the discharge time became shorter despite a large amount of available active mass remaining in the bottom part of the plates.Various current-collector designs were evaluated, e.g., one with varying resistance at each height; a side conductor placed along the plates and connected to them at the top, centre and bottom, etc. Results revealed an optimum collector design with which the maximum discharge capacity could be obtained. Furthermore, it was shown that the side conductor markedly improved the discharge performance because the active mass near the connecting parts was appreciably used.     

Modeling of a power electronic converter for EMC in the conduction emission frequency band

With the advancement of high‐frequency switching devices, electromagnetic interferences (EMI) have become problems in power electronic converter designs. It is necessary for an electromagnetic compatibility (EMC) design to prospect and consider its possible EMI levels. This paper describes how to compute effects from a power converter to an object point to reduce conduction EMI noises effectively by an appropriate design. Modeling techniques for converter elements are discussed for a model in the conduction emission frequency band by the parameter tuning method and for line constants by an analytical derivation. Then a derived model is simulated for harmonic distributions of loop currents and their magnetic fields. © 2002 Scripta Technica, Electr Eng Jpn, 139(1): 44–50, 2002: DOI 10.1002/eej.1145     

Tradeoffs in granularity and parallelization for a Monte Carlo shower simulation code

The EGS4 code, developed at Stanford Linear Accelerator Center, simulates electron-photon cascading phenomena. The original code is inherently sequential: processing one particle at a time. This paper reports on a series of experiments in parallelizing different versions of EGS4. Our parallel experiments were run on a 30-processor Sequent Balance B21 and a 6-processor Symmetry S27. We have considered the following approaches for parallel execution of this application code:

1. (1) Original sequential version modified for parallel processing: 1 processor;

2. (2) Version 1 run multiprocessed: 1 to 29 processors;

3. (3) Sequential version modified for large-grain parallel processing: 1 procssor;

4. (4) Version 3 run using the Sequent Microtasking Library: 1 to 29 processors.

For each approach, we discuss the relative advantages and disadvantages in the areas of coding effort, understandability and portability, as well as performance, and outline a new parallelization approach we are currently pursuing based on Large-Grain Data Flow techniques.