On the determination of thermal phenomena during drilling—Part II. Comparison of experimental and analytical twist drill temperature distributions

The analytical models, developed in Part I of this paper, for estimating the temperature distributions along the cutting edge and on the clearance face of a twist drill are evaluated using an experimental technique that measures average drill flank temperatures. While the transient model tends to overestimate the values of the average flank temperatures, especially during drilling to a one diameter hole depth, the temperatures predicted from the steady state model agree reasonably well with the experimental results. The difference between the analytical and experimental results varied with the physical and thermal properties of the powder metallurgy work materials used in this experiment. The analytical drill temperature distribution models are also compared with others found in the literature.     

Identification of potential biophysical and molecular signalling mechanisms underlying hyaluronic acid enhancement of cartilage formation

This study determined the effects of exogenous hyaluronic acid (HA) on the biomechanical and biochemical properties of self-assembled bovine chondrocytes, and investigated biophysical and genetic mechanisms underlying these effects. The effects of HA commencement time, concentration, application duration and molecular weight were examined using histology, biomechanics and biochemistry. Additionally, the effects of HA application on sulphated glycosaminoglycan (GAG) retention were assessed. To investigate the influence of HA on gene expression, microarray analysis was conducted. HA treatment of developing neocartilage increased compressive stiffness onefold and increased sulphated GAG content by 35 per cent. These effects were dependent on HA molecular weight, concentration and application commencement time. Additionally, applying HA increased sulphated GAG retention within self-assembled neotissue. HA administration also upregulated 503 genes, including multiple genes associated with TGF-β1 signalling. Increased sulphated GAG retention indicated that HA could enhance compressive stiffness by increasing the osmotic pressure that negatively charged GAGs create. The gene expression data demonstrate that HA treatment differentially regulates genes related to TGF-β1 signalling, revealing a potential mechanism for altering matrix composition. These results illustrate the potential use of HA to improve cartilage regeneration efforts and better understand cartilage development.     

Synthesis and Biopharmaceutical Evaluation of Imatinib Analogues Featuring Unusual Structural Motifs

A convenient synthesis of imatinib, a potent inhibitor of ABL1 kinase and widely prescribed drug for the treatment of a variety of leukemias, was devised and applied to the construction of a series of novel imatinib analogues featuring a number of non‐aromatic structural motifs in place of the parent molecule's phenyl moiety. These analogues were subsequently evaluated for their biopharmaceutical properties (e.g., ABL1 kinase inhibitory activity, cytotoxicity). The bicyclo[1.1.1]pentane‐ and cubane‐containing analogues were found to possess higher themodynamic solubility, whereas cubane‐ and cyclohexyl‐containing analogues exhibited the highest inhibitory activity against ABL1 kinase and the most potent cytotoxicity values against cancer cell lines K562 and SUP‐B15. Molecular modeling was employed to rationalize the weak activity of the compounds against ABL1 kinase, and it is likely that the observed cytotoxicity of these agents arises through off‐target effects.     

Development of an image-based method for the detection of archaeological buried relics using multi-temporal satellite imagery

Remote sensing has been successfully used for the exposure of shallow buried relics such as archaeological remains. The detection is mainly based on photointerpretation of high-resolution satellite or aerial images. Photointerpretation for archaeological purposes is focused on the identification of crop marks using visible and near infrared (VNIR) spectrum (e.g. vegetation indices) response, which is sensitive to vegetation stress. Detection of such marks is always performed through images of adequate spatial resolution, and therefore this procedure might be problematic in cases when there is a lack of accessibility to such kinds of data. This paper addresses this problem and illustrates an image-based method intended for the detection of crop marks using satellite data of inadequate spatial resolution. The overall methodology consists of seven separate steps. The method needs two areas of interest to be selected in the image, preferably in close proximity to one another. The first area is characterized as the ‘archaeological area under investigation'while the second is a vegetated non-archaeological area. These two areas are simultaneously examined in detail using spectral signatures, soil lines, and their phenological cycle characteristics. The proposed methodology has been successfully applied in three different areas in Cyprus and Greece, where the authors have already used the technique for validation purposes.     

Chemical vapor deposition of amorphous ruthenium-phosphorus alloy films

Chemical vapor deposition growth of amorphous ruthenium-phosphorus films on SiO₂ containing ∼ 15% phosphorus is reported. cis-Ruthenium(II)dihydridotetrakis-(trimethylphosphine), cis-RuH₂(PMe₃)₄ (Me = CH₃) was used at growth temperatures ranging from 525 to 575 K. Both Ru and P are zero-valent. The films are metastable, becoming increasingly more polycrystalline upon annealing to 775 and 975 K. Surface studies illustrate that demethylation is quite efficient near 560 K. Precursor adsorption at 135 K or 210 K and heating reveal the precursor undergoes a complex decomposition process in which the hydride and trimethylphosphine ligands are lost at temperatures as low at 280 K. Phosphorus and its manner of incorporation appear responsible for the amorphous-like character. Molecular dynamics simulations are presented to suggest the local structure in the films and the causes for phosphorus stabilizing the amorphous phase.     

Identifying user preferences with Wrapper-based Decision Trees

Wrapper feature selection approaches are widely used to choose a small subset of relevant features from a dataset. However, Wrappers suffer from the fact that they only use a single classifier. The downside to this is that each classifier will have its own biases and will therefore select very different features. To overcome the biases of individual classifiers, we propose a new data mining method called Wrapper-based Decision Trees (WDT). The WDT method uses multiple classifiers for selecting relevant features and decision trees to visualize relationships among the selected features. We use the WDT to investigate the influences of the levels of computer experience on users’ preferences for the design of search engines. The benefit of using WDT lies within the fact that it can uncover the most accurate set of relevant features to help differentiate the preferences of users with diverse levels of computer experience. The results indicate that the users with varied levels of computer experiences have different preferences regarding the following features: the number of icons, the arrangement of search results, and the presentation of error messages. Such findings can be used to develop personalized search engines to accommodate users’ different levels of computer experience.     

A COAL PYROLYSIS REACTOR SYSTEM WITH FAST ON-LINE COMPOSITION ANALYSIS BY GAS CHROMATOGRAPHY

The development of a coal pyrolysis reactor and a novel gas chromatography method for fast on-line composition analysis of pyrolysis products are presented. The annular fluidized bed reactor system minimizes particle agglomeration during the pyrolysis of plastic coals and the new column switching technique significantly reduces the time required for measuring the composition of low-volatile pyrolysis gases on a conventional gas chromatograph. Data from representative pyrolysis runs are presented and discussed.     

Unsaturated polyesters based on terephthalic acid: 4. Sequence distribution of crosslinks in styrene cured resins

The sequence distribution of the styrene crosslinks in a cured polyester formed from propylene glycol, terephthalic acid and maleic anhydride has been studied by ¹³C nuclear magnetic resonance and infrared spectroscopy. The n.m.r. method involved the degradation of the crosslinked polyester into a copolymer of styrene and fumaric acid and the interpretation of the peaks in the ¹³C spectrum, which arise from the quaternary phenyl carbon atoms in sequences of styrene units, by considering the ¹³C spectra of copolymer standards of styrene and diethyl fumarate. The crosslinking process was monitored directly by infra-red spectroscopy, and the distribution of sequence lengths of styrene units was then estimated by considering that crosslinking may be interpreted by a statistical treatment of copolymerization. Values of mol fractions of styrene units in sequences of monads, diads and triads determined by ¹³C n.m.r. and infra-red spectroscopy were in fair agreement.