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排序方式: 共有64条查询结果,搜索用时 15 毫秒
1.
RM Campbell EP Heimer M Ahmad HG Eisenbeis TJ Lambros Y Lee RW Miller PR Stricker AM Felix 《Canadian Metallurgical Quarterly》1997,49(6):527-537
In the present study, human growth hormone-releasing factor (hGRF) and analogs were successfully pegylated at the carboxy-terminus using a novel solid- and solution-phase strategy. Following synthesis, these pegylated hGRF analogs were evaluated for in vitro and in vivo biological activity. Specifically, hGRF (1-29)-NH2, [Ala15]-hGRF (1-29)-NH2, [desNH2Tyr1, D-Ala2, Ala15]-hGRF(1-29)-NH2 and [His1, Val2, Gln8, Ala15, Leu27]-hGRF(1-32)-OH were each C-terminally extended using a Gly-Gly-Cys-NH2 spacer (previously demonstrated not to alter intrinsic biological activity), and then monopegylated via coupling to an activated dithiopyridyl-PEG reagent. PEG moieties of 750, 2000, 5000 or 10,000 molecular weight (MW) were examined to determine the effect of polymer weight on activity. Initial biological evaluations in vitro revealed that all C-terminally pegylated hGRF analogs retained high growth hormone (GH)-releasing potencies, regardless of the MW of PEG polymer employed. Two of these pegylated hGRF analogs, [desNH2Tyr1, D-Ala2, Ala15]-hGRF (1-29)-Gly-Gly-Cys(NH2)-S-Nle-PEG5000 and [His1, Val2, Gln8, Ala15, Leu27]-hGRF(1-32)-Gly-Cys(NH2)-S-Nle-PEG5000, were subsequently evaluated in both pig and mouse models and found to be highly potent (in vivo potency range = 12-55-fold that of native hGRF). Relative to their non-pegylated counterparts, these two pegylated hGRF analogs exhibited enhanced duration of activity. 相似文献
2.
E. A. Johnson H. F. Lam L. S. Katafygiotis J. L. Beck 《Canadian Metallurgical Quarterly》2004,130(1):3-15
Structural health monitoring (SHM) is a promising field with widespread application in civil engineering. Structural health monitoring has the potential to make structures safer by observing both long-term structural changes and immediate postdisaster damage. However, the many SHM studies in the literature apply different monitoring methods to different structures, making side-by-side comparison of the methods difficult. This paper details the first phase in a benchmark SHM problem organized under the auspices of the IASC–ASCE Structural Health Monitoring Task Group. The scale-model structure adopted for use in this benchmark problem is described. Then, two analytical models based on the structure—one a 12 degree of freedom (DOF) shear-building model, the other a 120-DOF model, both finite element based—are given. The damage patterns to be identified are listed as well as the types and number of sensors, magnitude of sensor noise, and so forth. MATLAB computer codes to generate the response data for the various cases are explained. The codes, as well as details of the ongoing Task Group activities, are available on the Task Group web site at 〈http://wusceel.cive.wustl.edu/asce.shm/〉. 相似文献
3.
Lambros Lazuras Vassilis Barkoukis Despoina Ourda Haralambos Tsorbatzoudis 《Computers in human behavior》2013
Cyberbullying is an emerging form of aggression that utilizes information and communication technologies (ICTs). While cyberbullying incidents attract considerable attention, research on the causes and psychosocial predictors of cyberbullying is still limited. The present study used an integrated theoretical model incorporating empathy, moral disengagement, and social cognitions related to cyberbullying. Structured questionnaires were administered to 355 randomly selected adolescents (M = 14.7, SD = 1.20). Linear regression analysis showed that social norms, prototype similarity and situational self-efficacy directly predicted cyberbullying expectations. Multiple mediation modelling indicated that normative influences mediated the effects of moral disengagement and affective empathy on cyberbullying expectations. These findings provide valuable information regarding the effect of both distal and proximal risk factors for cyberbullying in adolescence, highlight the relationship between normative processes and moral self-regulation, and set the basis for related educational and preventive interventions. 相似文献
4.
In this work, 1 wt % carbon monoxide (CO) poly(ethylene‐carbon monoxide) (ECO) copolymer sheets were artificially exposed to ultraviolet (UV) light with a power density of 3 mW/cm2 for up to 130 h. A thorough mechanical characterization of the irradiated material was conducted, in which both the stress–strain data and the values of the quasistatic crack initiation and growth toughness were measured and correlated with companion uniaxial tensile tests and single‐edge‐notched fracture tests. Average values of the elastic modulus, failure strain, and failure stress were determined from the tensile tests. The full‐field optical technique of digital image correlation was used to quantify in‐plane deformation (displacements and displacement gradients) during the fracture experiments and to extract values of the crack initiation and growth fracture toughness. The elastic modulus increased monotonically with UV irradiation for the exposure times used in this investigation. In addition, for low irradiation times of less than 5 h, both the failure strain and failure stress of ECO decreased, and this caused a corresponding decrease in the crack initiation and growth toughness. However, for longer irradiation times, the failure strain remained almost invariable, whereas the failure stress increased by about 25% over that of unirradiated ECO. As a result, for longer irradiation times (>5 h), 1 wt % CO ECO became not only stiffer but also stronger and tougher, as quantified by companion fracture experiments. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 92: 139–148, 2004 相似文献
5.
Mark-Alexander Schwarzbich Hao Dai Lambros Kordelas Dietrich W. Beelen Aleksandar Radujkovic Carsten Müller-Tidow Peter Dreger Thomas Luft 《International journal of molecular sciences》2022,23(4)
Weight loss and metabolic activity influence outcome after allogeneic stem cell transplantation (alloSCT). This study evaluates pre-conditioning Leptin, a peptide hormone involved in metabolism and immune homeostasis, as a prognostic factor for survival, relapse and non-relapse mortality (NRM) following alloSCT. Leptin serum levels prior to conditioning were determined in a cohort of patients transplanted for various hematologic malignancies (n = 524) and correlated retrospectively with clinical outcome. Findings related to patients with acute leukemia (AL) from this sample were validated in an independent cohort. Low pre-conditioning serum Leptin was an independent prognostic marker for increased risk of relapse (but not of NRM and overall mortality) following alloSCT for AL of intermediate and advanced stage (beyond first complete remission). Multivariate analysis revealed a hazard ratio (HR) for relapse of 0.75 per log2 increase (0.59–0.96, p = 0.020). This effect was similar in an independent validation cohort. Pre-conditioning serum Leptin was validated as a prognostic marker for early relapse by fitting the multivariate Cox model to the validation data. Pre-conditioning serum Leptin levels may serve as an independent prognostic marker for relapse following alloSCT in intermediate and advanced stage AL patients. Prospective studies are required to prove whether serum Leptin could be used for guiding nutritional intervention in patients with AL undergoing alloSCT. 相似文献
6.
7.
Lazuras Lambros; Eiser J. Richard; Rodafinos Angelos 《Canadian Metallurgical Quarterly》2009,28(6):770
Objective: To examine the effects of normative influences on adolescent smoking in Greece, a country with weak social norms against smoking and relatively ineffective tobacco control policies. Design: A cross-sectional survey methodology was employed, and a representative sample of Greek high school students was recruited (N = 1,920, M age = 14 years). Main Outcome Measures: Normative beliefs, attitudes, perceived behavioral control, self-esteem, and intentions to smoke. Results: Multiple-regression and mediation analyses were conducted. The effects of public smoking on intentions to smoke were mediated by beliefs of perceived prevalence of smoking among peers, subjective norms, and situational temptations. Self-esteem significantly moderated the effects of subjective norms on intentions to smoke. Conclusions: Prosmoking norms in one’s environment become internalized into biased normative beliefs about smoking, and increase susceptibility to smoke under social pressure. The effect of subjective norms on intentions to smoke was stronger among adolescents with low self-esteem, suggesting that self-esteem may act as a vulnerability factor in the process of smoking initiation. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
8.
Dimitris Pachakis Lambros S. Katafygiotis Aspasia Zerva 《Canadian Metallurgical Quarterly》2007,133(7):844-848
This note compares in detail four commonly used schemes for the simulation of spatially variable ground motions. Emphasis is placed not only on the conformity of the simulations with the power and cross spectral density of the random field but, also, on the examination of the consistency of the simulations with the homogeneity condition, and the (Fourier) amplitude variability of the simulations. It is shown that, whereas three techniques that simulate ground motions in parallel satisfy the homogeneity requirement, produce simulations with random amplitudes, and amplitude and phase variability consistent with that of recorded data, one technique that simulates motions in sequence does not. 相似文献
9.
Spectral density estimation of stochastic vector processes 总被引:1,自引:0,他引:1
Ka-Veng Yuen Lambros S Katafygiotis James L Beck 《Probabilistic Engineering Mechanics》2002,17(3):295
A spectral density matrix estimator for stationary stochastic vector processes is studied. As the duration of the analyzed data tends to infinity, the probability distribution for this estimator at each frequency approaches a complex Wishart distribution with mean equal to an aliased version of the power spectral density at that frequency. It is shown that the spectral density matrix estimators corresponding to different frequencies are asymptotically statistically independent. These properties hold for general stationary vector processes, not only Gaussian processes, and they allow efficient calculation of updated probabilities when formulating a Bayesian model updating problem in the frequency domain using response data. A three-degree-of-freedom Duffing oscillator is used to verify the results. 相似文献
10.
In this paper the problem of calculating the probability of failure of linear dynamic systems subjected to random vibrations is considered. This is a very important and challenging problem in structural reliability. The failure domain in this case can be described as a union of linear failure domains whose boundaries are hyperplanes. Each linear limit state function can be completely described by its own design point, which can be analytically determined, allowing for an exact analytical calculation of the corresponding failure probability. The difficulty in calculating the overall failure probability arises from the overlapping of the different linear failure domains, the degree of which is unknown and needs to be determined. A novel robust reliability methodology, referred to as the domain decomposition method (DDM), is proposed to calculate the probability that the response of a linear system exceeds specified target thresholds. It exploits the special structure of the failure domain, given by the union of a large number of linear failure regions, to obtain an extremely efficient and highly accurate estimate of the failure probability. The number of dynamic analyses to be performed in order to determine the failure probability is as low as the number of independent random excitations driving the system. Furthermore, calculating the reliability of the same structure under different performance objectives does not require any additional dynamic analyses. Two numerical examples are given demonstrating the proposed method, both of which show that the method offers dramatic improvement over standard Monte Carlo simulations, while a comparison with the ISEE algorithm shows that the DDM is at least as efficient as the ISEE. 相似文献