iRGD-reinforced,photo-transformable nanoclusters toward cooperative enhancement of intratumoral penetration and antitumor efficacy

Nano Research - Insufficient intratumoral penetration greatly hurdles the anticancer performance of nanomedicine. To realize highly efficient tumor penetration in a precisely and spatiotemporally...     

BP神经网络在液压试验台故障诊断中的应用

分析了BP神经网络的结构及算法，并对液压试验台的故障模式用BP神经网络来进行诊断，从而提出了一种新的解决液压试验台故障诊断的方法。     

应用于电磁超声的DE类功率放大器驱动电路设计

为了进一步增强电磁超声激励源的激发效能,提高电磁超声换能器的工作效率,基于射频技术提出了一种DE类射频功率放大器,通过采用隔离电源方法,有效地解决了高边金属-氧化物半导体场效应晶体管(MOSFET)的“浮地”问题,实现了高频隔离.通过分析MOSFET开关工作状态及控制特性,确立了MOSFET开关的基本工作过程,从而建立了一种MOSFET驱动电路设计方法.通过对关键元件的选型设计与算法研究,构建了DE类功率放大器的驱动电路.实验结果表明:设计的MOSFET驱动电路的输出信号电压幅值为13.4V,占空比50％,频率为1MHz,输出信号稳定,实现了对MOSFET的可靠驱动,能够满足实际应用.     

A Comparative study on multiobjective reliable and robust optimization for crashworthiness design of vehicle structure

Design optimization without considering uncertainties of system variables and parameters can be problematic in real life. In order to take into account the effect of uncertainties, reliable and robust design schemes have proven effective, but limited studies have been reported to compare their difference in a multiobjective framework. This paper takes a typical vehicle structure subject to offset frontal crashing scenario as an example to compare reliable and robust designs with their deterministic counterpart. The thicknesses of some key components of vehicle frontal structures were selected as design variables, the vehicle weight and energy absorption as the objectives, deceleration and firewall intrusion as the constraints. The deterministic multiobjective optimization problem was first solved by adopting Design of Experimental (DOE), metamodels and Non-dominated Sorting Genetic Algorithm II (NSGA-II). Take into account the uncertainties, a Monte Carlo Simulation (MCS) is adopted to generate random distributions of the objective and constraint functions for each design. For the reliability-based optimization the desired reliabilities of 90 %, 95 % and 99 % are considered, respectively. For the robustness-based optimization, two different formulation strategies are adopted. The optimization showed that the reliable and robust Pareto fronts are shifted away from their deterministic counterpart due to uncertainties. The different Pareto fronts yielded from the deterministic, reliable and robust designs are compared to provide some quantitative insights into how to apply these different design schemes for resolving uncertainty problems. It is shown that, compared with the baseline design, the optimizations enhance the crashworthiness of vehicle, though more conservative solutions could have been generated from the reliable and robust optimizations.     

蒙特卡罗法及其在射弹散布仿真中的应用

作战仿真的真实性需要对抗双方火力射击效果的真实体现。文中提出了一种利用蒙特卡罗法进行射弹散布仿真的方法 ,并将结果与实际情况进行了比较。该方法已用于装甲兵数字化作战仿真实验室的作战仿真中     

面向普适计算的自适应模糊访问控制方法

普适环境中的上下文信息是普适访问控制的关键因素,对主体的授权和对主体使用权限过程的控制具有决定性影响。系统安全强度和安全策略应随上下文的变化而动态改变。传统访问控制模型均未考虑上下文对安全强度和安全策略的动态影响,不适合普适计算环境。提出了普适环境下安全强度和安全策略随上下文动态变化的思想,基于区间值模糊集合理论建立了上下文信息相关的产生式规则,设计了一种简单高效的区间值模糊访问控制方法,以提高普适计算系统中安全强度和安全策略的自适应性,更符合普适环境。     

基于多帧平均和小波分析的X射线影像图像去噪处理

分析了低强度X射线影像系统图像噪声来源及特点，以此提出了处理该图像噪声的“多帧平均滤波 小波变换滤波”的复合算法。通过对峰值信噪比的计算表明，该方法明显优于任何单一算法，取得较好效果。     

光纤光栅用于应变/温度传感初探

本文介绍了光纤光栅应变和温度传感的原理，完成了光纤光栅用于应变和温度传感器的初步实验。分析表明波长为８２７ｎｍ的光纤光栅应变灵敏度为０．６５ｐｍ／ｕε，温度灵敏度为５．２ｐｍ／Ｃ。     

乙酸乙酯合成反应液的快速气相色谱分析

利用充填有GDX—104(60～80目)的不锈钢色谱柱,以氢气做载气,TCD检测器检测,分析了乙酸乙酯合成反应液中反应物与产物的含量。本方法的精密度与准确度均较高,RSD为0.89％,回收率为99.5％,难分离物质对的分离度R>1.2,分析时间小于3min。     

非均质结构裂纹的J积分守恒性的理论研究(Ⅱ)

用数学分析方法论证了焊缝区有垂直裂纹时J积分的守恒性，又用弹塑性有限元方法进行了数值验证．首次提出了J积分与路径有关的理论证明，为J积分在压力容器缺陷安全评定的应用提供了必要的依据．