To provide a basis for the selection of suitable emulsifiers in oil-in-water emulsions used as tissue analogs for MRI experiments. Three different emulsifiers were investigated with regard to their ability to stabilize tissue-like oil-in-water emulsions. Furthermore, MR signal properties of the emulsifiers themselves and influences on relaxation times and ADC values of the aqueous phase were investigated.
Materials and methods
Polysorbate 60, sodium dodecyl sulfate (SDS) and soy lecithin were used as emulsifiers. MR characteristics of emulsifiers were assessed in aqueous solutions and their function as a stabilizer was examined in oil-in-water emulsions of varying fat content (10, 20, 30, 40, 50%). Stability and homogeneity of the oil-in-water emulsions were evaluated with a delay of 3 h and 9 h after preparation using T1 mapping and visual control. Signal properties of the emulsifiers were investigated by 1H-MRS in aqueous emulsifier solutions. Relaxometry and diffusion weighted MRI (DWI) were performed to investigate the effect of various emulsifier concentrations on relaxation times (T1 and T2) and ADC values of aqueous solutions.
Results
Emulsions stabilized by polysorbate 60 or soy lecithin were stable and homogeneous across all tested fat fractions. In contrast, emulsions with SDS showed a significantly lower stability and homogeneity. Recorded T1 maps revealed marked creaming of oil droplets in almost all of the emulsions with SDS. The spectral analysis showed several additional signals for polysorbate and SDS. However, lecithin remained invisible in 1H-MRS. Relaxometry and DWI revealed different influences of the emulsifiers on water: Polysorbate and SDS showed only minor effects on relaxation times and ADC values of aqueous solutions, whereas lecithin showed a strong decrease in both relaxation times (r1,lecithin = 0.11 wt.%−1 s−1, r2,lecithin = 0.57 wt.%−1 s−1) and ADC value (Δ(ADC)lecithin = − 0.18 × 10–3 mm2/s⋅wt.%) with increasing concentration.
Conclusion
Lecithin is suggested as the preferred emulsifier of oil-in-water emulsions in MRI as it shows a high stabilizing ability and remains invisible in MRI experiments. In addition, lecithin is suitable as an alternative means of adjusting relaxation times and ADC values of water.
This paper considers the evolution of the velocity and temperature fields within a jet of fluid on a thermally insulated wall. Numerical solutions are obtained for a range of Prandtl numbers and for a class of initial velocity and temperature profiles relevant to intrusion jets observed in certain thermal cavity flows. Numerical results are compared with asymptotic solutions which describe the initial structure of the jet and its subsequent diffusion at large distances downstream. 相似文献
Patients with category-specific deficits have motivated a range of hypotheses about the structure of the conceptual system. One class of models claims that apparent category dissociations emerge from the internal structure of concepts rather than fractionation of the system into separate substores. This account claims that distinctive properties of concepts in the living domain are vulnerable because of their weak correlation with other features. Given the assumption that mutual activation among correlated properties produces faster activation in the normal system, the authors predicted a disadvantage for the distinctive features of living things for unimpaired adults. Results of a speeded feature verification study supported this prediction, as did a computational simulation in which networks mapped from orthography to semantics. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
Molecular electronics is an emerging field that seeks to build faster, cheaper, denser computers from nanoscale devices. The nanocell is a molecular electronics design wherein a random, self-assembled array of molecules and metallic nanoparticles is addressed by a relatively small number of input/output pins. The challenge then is to program the nanocell post-fabrication. We have previously demonstrated the ability to program individual simulated nanocells as logic gates. In this paper, we further explore the problem of programming nanocells and consider connecting nanocells into circuits using bistable latches at the interconnects. These latches are critical because they permit signal restoration. Simulated nanocell circuits for logic and memory are presented here. 相似文献
Subjected research on Ivey's (1971) microcounseling program to a comprehensive meta-analytic review. A multistage sampling procedure resulted in the identification of 81 admissible studies. Glass's (1976) effect size (ES) statistic was used to estimate average effects for each study and across all studies, and the relation between ES and the sampling distribution of several important methodological and substantive characteristics was assessed. The most conservative overall ES statistic fell in the large-effect category. ESs were influenced differentially by the populations from which Ss were drawn and by the type of client the Ss interviewed when data for ratings on dependent measures were acquired. There was some evidence that the dependent measures used in microcounseling research are limited, which led to a conclusion that research on the teaching of more complex skills may be delayed. The microcounseling program has made a contribution to counseling training and may have pointed the way to new training models. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
Ecological momentary assessment (EMA) consists of assessing phenomena in real time in the natural environment. EMA allows for more fine-grained analyses of addictive behavior and minimizes threats to internal validity, such as recall biases and errors. However, because of the intensive monitoring involved in EMA, measurement reactivity is a concern. To test whether EMA with palmtop personal computers induces reactivity, the authors compared smoking-related outcomes between smokers using EMA and those not using EMA during a quit attempt. The use of no-EMA control groups has been rare in reactivity investigations to date. The EMA protocol included event-contingent assessments (smoking episodes, urge episodes) and random assessments. Outcomes included biologically confirmed abstinence and self-report measures of withdrawal, self-efficacy, motivation, affect, and temptations. Participants were smokers motivated to quit (N = 96). They were randomized to 1 of 3 groups: EMA for the week preceding a planned quit date, EMA for the week following the quit date, and no EMA. Abstinence rates did not differ between the groups at Day 7 or at Day 28 postcessation. For the 20 subscales assessed at each of 3 assessment times, there were significant differences between participants with and without EMA experience for 3 subscales at the 1st of 3 assessment times, and significant differences for 3 different subscales at the 3rd assessment time. These differences suggest some reactivity to EMA, although the inconsistent pattern across time indicates that further research is needed to definitively conclude that EMA induces reactivity. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
The crystalline phase development and microstructural changes with heating of sol-gel-derived lead titanate (PT) particles and films on silica with and without a fugitive (or removable) diffusion barrier layer were investigated. Amorphous gel-derived PT particles were deposited on SiO2-coated TEM grids with and without polyimide (PI) or carbon barrier layers between SiO2 and PT. TEM analysis showed that PI or carbon barriers prevented reaction between the gel-derived PT particles and SiO2. PT particles crystallize and then the PI or carbon film decomposes. Sol-gel-derived PT films were deposited on oxidized Si substrates (Si/SiO2) with and without a PI barrier layer. Perovskite PT films were prepared on Si/SiO2 substrates with a PI barrier; however, some porosity remained in the films. Identically prepared films without the PI barrier formed a mixture of pyrochlore and perovskite. X-ray photoelectron spectroscopy results indicate that the PI film pre- vents the diffusion of Si into the PT film. 相似文献