Model-driven engineering for mobile robotic systems: a systematic mapping study

Software and Systems Modeling - Mobile robots operate in various environments (e.g. aquatic, aerial, or terrestrial), they come in many diverse shapes and they are increasingly becoming parts of...     

Metabolism of phospholipids in the yeast Schizosaccharomyces pombe

The fission yeast Schizosaccharomyces pombe is an important model organism for the study of fundamental questions in eukaryotic cell and molecular biology. A plethora of cellular processes are membrane associated and/or dependent on the proper functioning of cellular membranes. Phospholipids are not only the basic building blocks of cellular membranes; they also serve as precursors to numerous signaling molecules. In this review, we describe the biosynthetic pathways leading to major S. pombe phospholipids, how these pathways are regulated, and what is known about degradation and turnover of fission yeast phospholipids. This review also addresses the synthesis, regulation and the role of water-soluble phospholipid precursors. The last chapter of the review is devoted to the use of S. pombe for the biotechnological production of value-added lipid molecules.     

Non-pinched, minimum energy distillation designs

Non-pinched, minimum energy solutions are important class of distillation designs that offer the potential advantage of a better trade-off between capital investment and operating costs. In this paper, two important tasks associated with non-pinched distillation designs are studied. Thus the novel contributions of this work to the literature are

(1) A comprehensive methodology for finding non-pinched minimum energy designs.

(2) Understanding of the reasons for the existence of non-pinched distillation designs.

It is shown that the recent shortest stripping line distance approach of Lucia et al. [Lucia, A., Amale, A. and Taylor, R., 2007, Distillation pinch points and more. Comput Chem Eng, available on-line] is capable of systematically and reliably finding non-pinched, minimum energy distillation designs. In addition, we provide an understanding of the reasons behind the existence of non-pinched designs, which include trajectories that follow unstable branches of a pinch point curve in azeotropic systems, the inherent looping structure of trajectories in hydrocarbon separations, and the presence of ancillary constraints in multi-unit processes like extraction/distillation. Several distillation examples are studied and many numerical results and geometric illustrations are presented that show the shortest stripping line distance methodology is indeed a powerful and systematic tool for computing non-pinched, minimum energy designs and that support the underlying reason we provide for the existence of non-pinched designs.     

Spyware的安全风险: 我们应该变得更聪明

对于在计算机上秘密和恶意地安装spyware(间谍软件)所带来的安全风险、隐私泄露以及绩效损失,许多用户都只是有一些含糊的认识。只有极少数用户知道spyware所具有的多种形式以及它们所采取的一些非常恶劣的行动,除了泛泛地知道spyware是一种不请自来的、恶意的软件之外,普通用户对其知之甚少。直到最近,人们还是认为spyware的危害比不上病毒和垃圾邮件。但是,我认为Spyware具有比病毒和垃圾邮件更大的威胁。相较于电子邮件信用卡诈骗(phishing),spyware对金融所产生的威胁不仅范围要大得多,也要严重得多。另外,     

Material constant sensitivity boundary integral equation for anisotropic solids

In this paper, the material constant sensitivity boundary integral equation is presented, and its numerical solution proposed, based on boundary element techniques. The formulation deals with plane problems with general rectilinear anisotropy. Expressions for the computation of sensitivities for displacements, tractions, strains and stresses are derived, both for boundary and interior points. The sensitivities can be computed with respect to the bulk material properties or to the properties of part of the domain (inclusions, coatings, etc.). To assess the accuracy of the proposed approach, the computed results are compared to analytical ones derived from exact solutions obtained by complex potential theory, when possible, or finite difference derivatives otherwise. Copyright © 2005 John Wiley & Sons, Ltd.     

Symmetry properties and bifurcation analysis of a class of periodically forced chemical reactors

In this work, we discuss how periodic forcing may induce symmetry properties into mathematical models of chemical reactors. We define a class of reactors subjected to discontinuous periodic forcing, and show that all the reactors belonging to this class have spatio-temporal symmetry. This symmetry and its influence on the possible bifurcation scenarios are discussed. The bifurcation analysis is carried out with suitable discrete systems that exploit a property of the Poincaré map. In fact, it is shown that the spatio-temporal symmetry induced by the forcing makes the Poincaré map of the continuous system an iterate of another map. On this basis, a technique to implement parameter continuation methods is proposed. With such a technique, it is also possible to characterize symmetric and nonsymmetric regimes and unstable limit sets otherwise undetected with “bruteforce” approaches. Examples for reverseflow reactors and networks of n-reactors with periodically switched feed and discharge positions are presented.     

General review of recent activities in acoustic emission technology in Italy

This paper describes the present situation in Italy in the field of Acoustic Emission researches and applications.Information on the level of instrumentation development is given. Both multichannel and multiparameter systems for large structure examination in real time and data logging systems for continuous surveillance purposes are considered.The expertise accumulated in the application of AE to pressure vessel examination during hydrotest is mentioned, this being oriented to pressure components of conventional power stations and chemical plants.Particular attention is recently paid to mechanical fatigue tests. These were conducted on intermediate PWR nuclear pressure vessel, reduced scale offshore nodes and full scale prototype aircraft.A considerable activity has been carried out on application of AE technique to the detection of fluid leakages in power plant components. Both intrusive and non-intrusive methods have been considered. Many boilers and pre-heaters of thermal power plants have been instrumented for an on-line AE monitoring during operation. The problem of the loose part monitoring has been also considered.Several basic researches for material characterization by AE have been also conducted. Different composite material, carbon and austenitic steels, metal alloys have been studied.     

Adenosine Signaling in Mast Cells and Allergic Diseases

Adenosine is a nucleoside involved in the pathogenesis of allergic diseases. Its effects are mediated through its binding to G protein-coupled receptors: A1, A2a, A2b and A3. The receptors differ in the type of G protein they recruit, in the effect on adenylyl cyclase (AC) activity and the downstream signaling pathway triggered. Adenosine can produce both an enhancement and an inhibition of mast cell degranulation, indicating that adenosine effects on these receptors is controversial and remains to be clarified. Depending on the study model, A1, A2b, and A3 receptors have shown anti- or pro-inflammatory activity. However, most studies reported an anti-inflammatory activity of A2a receptor. The precise knowledge of the adenosine mechanism of action may allow to develop more efficient therapies for allergic diseases by using selective agonist and antagonist against specific receptor subtypes.     

Immune Checkpoint Inhibitors: A Promising Treatment Option for Metastatic Castration-Resistant Prostate Cancer?

Since 2010, several treatment options have been available for men with metastatic castration-resistant prostate cancer (mCRPC), including immunotherapeutic agents, although the clinical benefit of these agents remains inconclusive in unselected mCRPC patients. In recent years, however, immunotherapy has re-emerged as a promising therapeutic option to stimulate antitumor immunity, particularly with the use of immune checkpoint inhibitors (ICIs), such as PD-1/PD-L1 and CTLA-4 inhibitors. There is increasing evidence that ICIs may be especially beneficial in specific subgroups of patients with high PD-L1 tumor expression, high tumor mutational burden, or tumors with high microsatellite instability/mismatch repair deficiency. If we are to improve the efficacy of ICIs, it is crucial to have a better understanding of the mechanisms of resistance to ICIs and to identify predictive biomarkers to determine which patients are most likely to benefit. This review focuses on the current status of ICIs for the treatment of mCRPC (either as monotherapy or in combination with other drugs), mechanisms of resistance, potential predictive biomarkers, and future challenges in the management of mCRPC.     

Behavioral Changes in Workers of the Leaf-Cutting Ant Atta sexdens rubropilosa Induced by Chemical Components of Eucalyptus maculata Leaves

The response of Atta sexdens rubropilosa Forel workers to essential oils, epicuticular wax and hexane, dichloromethane, ethyl acetate, and methanol extracts of Eucalyptus maculata was evaluated. Hexane extracts of E. maculata interfered with the recognition mechanism among workers. The main active compounds identified from this plant were the sesquiterpenes elemol and beta-eudesmol. These compounds may be responsible for the resistance of this species to ant attack.