Development of a simple low-cost solar simulator for indoor collector testing

Indoor test methods for solar collectors are widely accepted and recommended by ASHRAE. The development of a solar simulator for indoor testing and the certification procedure for photo-thermal solar devices is discussed in this paper. The system consists of 14 quartz halogen lamps and provides a testing area of about 1 × 1 m. The irradiance can be varied from 400 to 1500 W/m². This is achieved by varying the input power supplied to individual lamps. The radiation output characteristics of a single lamp have been studied. The distribution of intensity over the covered area of 1·20 × 1·20 m has been recorded using a precision Eppley pyranometer.A variety of collectors—evacuated tubular collectors and flat-plate collectors of both liquid and air heating types—has been tested under sufficiently stable insolation conditions. Results for a conventional solar air heater are presented together with suggestions for further improvements.     

Crystal structure,phonon modes,and bond characteristics of AgPb2B2V3O12 (B = Mg,Zn) microwave ceramics

AgPb₂B₂V₃O₁₂ (B = Mg, Zn) ceramics with low sintering temperature were synthesized via the conventional solid-state reaction route. Rietveld refinements of the X-ray diffraction patterns confirm cubic symmetry with space group . The number of observed vibrational modes and those predicted by group theoretical calculations also confirm the space group. At the optimum sintering temperature of 750°C/4 hours, AgPb₂Mg₂V₃O₁₂ has a relative permittivity of 23.3 ± 0.2, unloaded quality factor () of 26 900 ± 500 GHz (), and temperature coefficient of resonant frequency of 19.3 ± 1 ppm/°C, while AgPb₂Zn₂V₃O₁₂ has the corresponding values of 26.4 ± 0.2, 28 400 ± 500 GHz () and –18.4 ± 1 ppm/°C at 590°C/4 hours. Microwave dielectric properties of a few reported garnets and Pb₂AgB₂V₃O₁₂ (B = Mg, Zn) ceramics were correlated with their intrinsic characteristics such as the Raman shifts as well as width of A_1g Raman bands. Higher quality factor was obtained for lower full width at half-maxima (FWHMs) values of A_1g modes. The increase in B-site bond valence contributes to high and low |τ_f| with the substitution of Zn²⁺ by Mg²⁺. Furthermore, the high ionic polarizability and unit cell volume with Zn²⁺substitution contribute to increased relative permittivity.     

Design and analysis of RF MEMS shunt switch for V-band applications

Microsystem Technologies - In this paper, we have designed and simulations of RF MEMS shunt switch. The electro-mechanical and electromagnetic analysis of the switch have been done using COMSOL...     

Ascorbic acid imprinted polymer-modified graphite electrode: A diagnostic sensor for hypovitaminosis C at ultra trace ascorbic acid level

A new kind of molecularly imprinted polymer-modified graphite electrode was fabricated by “grafting-to” approach, incorporating sol–gel technique, for the detection of acute deficiency in serum ascorbic acid level (SAAL), manifesting hypovitaminosis C. The modified electrode exhibited ascorbic acid (AA) oxidation at less positive potential (0.0 V) than the earlier reported methods, resulting in a limit of detection as low as 6.13 ng mL⁻¹ (RSD = 1.2%, S/N = 3). The diffusion coefficient (1.096 × 10⁻⁵ cm² s⁻¹), rate constant (7.308 s⁻¹), and Gibb's free energy change (−12.59 kJ mol⁻¹) due to analyte adsorption, were also calculated to explore the kinetics of AA oxidation. The proposed sensor was found to enhance sensitivity substantially so as to detect ultra trace level of AA in the presence of other biologically important compounds (dopamine, uric acid, etc.), without any cross interference and matrix complications from biological fluids and pharmaceutical samples.     

Gold nanorods mediated controlled release of doxorubicin: nano-needles for efficient drug delivery

Use of cysteamine hydrochloride (Cys-HCl) protected gold nanorods (GNRs) as efficient carrier of widely used anti-cancer drug doxorubicin using folic acid as navigational molecule is presented in this work. GNRs were found to have excellent drug loading capacity of >97 %. A detailed comprehension of in vitro drug release profile under ideal physiological condition was found to obey 1st order kinetics at pH 6.8, 5.3 and 7.2, an ideal milieu for drug delivery to solid tumours.     

Effect of Transition Metals on Polysialic Acid Structure and Functions

Polysialic acid (PSA) is one of the most abundant glycopolymer present in embryonic brain, and it is known to be involved in key roles such as plasticity in the central nervous system, cell adhesion, migration and localization of neurotrophins. However, in adult brain, its expression is quite low. The exception to this is in Alzheimer′s disease (AD) brain, where significantly increased levels of polysilylated neural cell adhesion molecule (PSA‐NCAM) have been reported. Here, we confirm the role of PSA as a metal chelator, allowing it to decrease cytotoxicity caused by high levels of transition metals, commonly found in AD brain, and as a regulator of cell behavior. UV‐visible (UV‐vis) and circular dichroism (CD) spectroscopy, atomic force microscopy (AFM), and isothermal titration calorimetry (ITC) techniques were used to investigate the assembly of PSA–metals complexes. These PSA–metal complexes exhibited less toxicity compared to free metal ions, and in particular, the PSA–Cu²⁺ complex synergistically promoted neurite outgrowth in PC12 cells.     

Modulatory Effects of Biosynthesized Gold Nanoparticles Conjugated with Curcumin and Paclitaxel on Tumorigenesis and Metastatic Pathways—In Vitro and In Vivo Studies

Background: Breast cancer is the most common cancer in women globally, and diagnosing it early and finding potential drug candidates against multi-drug resistant metastatic breast cancers provide the possibilities of better treatment and extending life. Methods: The current study aimed to evaluate the synergistic anti-metastatic activity of Curcumin (Cur) and Paclitaxel (Pacli) individually, the combination of Curcumin–Paclitaxel (CP), and also in conjugation with gold nanoparticles (AuNP–Curcumin (Au-C), AuNP–Paclitaxel (Au-P), and AuNP–Curcumin–Paclitaxel (Au-CP)) in various in vitro and in vivo models. Results: The results from combination treatments of CP and Au-CP demonstrated excellent synergistic cytotoxic effects in triple-negative breast cancer cell lines (MDA MB 231 and 4T1) in in vitro and in vivo mouse models. Detailed mechanistic studies were performed that reveal that the anti-cancer effects were associated with the downregulation of the expression of VEGF, CYCLIN-D1, and STAT-3 genes and upregulation of the apoptotic Caspase-9 gene. The group of mice that received CP combination therapy (with and without gold nanoparticles) showed a significant reduction in the size of tumor when compared to the Pacli alone treatment and control groups. Conclusions: Together, the results suggest that the delivery of gold conjugated Au-CP formulations may help in modulating the outcomes of chemotherapy. The present study is well supported with observations from cell-based assays, molecular and histopathological analyses.     

Optimal operation and tracking control of vapor-recompressed batch distillation

Vapor recompressed batch distillation (VRBD) is an energy-integrated configuration which works on the principle of a heat pump. Operation of such a column is challenging due to unsteady, nonlinear dynamics and strong interplay between separation and energy efficiency. In this paper, a two-step approach is proposed for optimal operation and control of such a column. Initially, an openloop optimal operation policy is generated for maximization of an overall performance index using offline optimization. To this end, three performance indices are proposed to capture interplay between separation and energy efficiency. Subsequently, a model-based output feedback controller is designed to track this optimal performance trajectory. The effectiveness of the proposed approach is demonstrated using a benzene-toluene separation case study wherein it is shown that the proposed approach helps to achieve optimal operation in the presence of operational disturbances.     

Estimation of Effect of Fog on Terrestrial Free Space Optical Communication Link

Wireless Personal Communications - Free Space Optical Communication Technology is expected as the successor to the existing communication technologies as many of its features like high bandwidth,...     

Enhanced Dissolution of Ibuprofen Using Solid Dispersion with Polyethylene Glycol 20000

To improve its dissolution, ibuprofen solid dispersions (SDs) were prepared in a relatively easy and simple manner, characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR), and evaluated for solubility and in vitro drug release. Loss of individual surface properties during melting and re-solidification as revealed by SEM micrographs indicated the formation of effective SDs. Absence or shifting toward the lower melting temperature of the drug peak in SDs in DSC study indicated the possibilities of drug–polymer interactions. FTIR spectra showed the presence of drug crystalline in SDs. The effect of improved dissolution on the oral absorption of ibuprofen in rats was also studied. Quicker release of ibuprofen from SDs in rat intestine resulted in a significant increase in AUC and C_max, and a significant decrease in T_max over pure ibuprofen. Preliminary results from this study suggested that the preparation of fast dissolving ibuprofen SDs by low-temperature melting method using polyethylene glycol 20000 as a meltable hydrophilic polymer carrier could be a promising approach to improve solubility, dissolution, and absorption rate of ibuprofen.