Calculated and Experimental Estimation of Absorbed Mechanical Work in Deformation of Synthetic Fibres

Methods are proposed for obtaining the elastic and absorbed components of deformation and mechanical work expended in the region of a nondestructive mechanical effect from the stress-strain diagrams or by calculated prediction. The closeness of the values of the absorbed and correspondingly the elastic components obtained with the measured or predicted stress-strain diagram totally confirm the satisfactory reliability of modeling the physicomechanical properties of a fibre in the form of an integral equation in which the nonlinear-hereditary kernel analytically reflects the activating character of the mechanical effect combined with the concept of the deformation-time analogy in normalized form [5].     

DNA methylation and developmental genes in lymphomagenesis--more questions than answers?

There is now considerable evidence suggesting that alterations in the DNA methylating machinery play an important role in tumorigenesis and tumour progression. For example, focal hypermethylation and generalised genomic demethylation are features of many different types of neoplasms. It is thought that tumorigenesis and tumour progression may be caused by hypermethylation induced mutational events and silencing of genes which control cellular proliferation and/or demethylation induced reactivation of genes which may only be required during embryological development. Consequently, we have begun to investigate the role of DNA methylation and developmental genes in malignant lymphoproliferative diseases. Previously, in all cases of non-Hodgkins lymphoma and leukemia studied, we have shown that the myogenic developmental gene Myf-3 is abnormally hypermethylated. In this review we discuss the possible significance of these findings since in vitro studies suggest that Myf-3 may play an important role in control of the cell cycle and therefore lymphomagenesis. In vitro and in vivo evidence suggests that PAX genes may also have oncogenic potential. The PAX family of developmental genes are involved in cellular differentiation, proliferation and cell migration. Expression of PAX3 in particular is associated with cellular mobility. Our previous studies have indicated that alternate regional expression of PAX genes may be controlled by DNA methylation. Therefore, we have proposed that abnormal methylation profiles of PAX3 may be associated with neoplastic transformation and/or metastatic potential. Results thus far reveal that the paired box of PAX3 is abnormally hypermethylated and the homeobox abnormally hypomethylated in lymphomas and leukemias. These new findings are consistent with our postulate and support the idea that inappropriate methylation induced activation or inactivation of developmental genes such as Myf-3 and PAX3 play an important role in lymphomagenesis and disease progression and that inspection of the methylation status of other developmental genes is warranted.     

Composite material in the aluminum oxide-zirconium dioxide system

A dispersion-hardened material with average flexural strength 580 ± 40 MPa, which is a promising building material, has been fabricated by introducing a CaO-ZnO-Al₂O₃-SiO₂ eutectic additive and tetragonal zirconium dioxide into aluminum oxide synthesized by calcining the hydroxide. The sintering temperature of this ceramic is 1550°C. The properties of the eutectic of this system are analyzed, and the optimal liquid-phase composition which gives intense sintering of the aluminum oxide is determined. __________ Translated from Steklo i Keramika, No. 4, pp. 12–15, April, 2007.     

Operation of an experimental facility for fabrication of fuel elements and fuel assemblies of the bor-60 containing vibrocompacted fuel

Translated from Atomnaya Énergiya, Vol. 67, No. 5, pp. 320–323, November, 1989.     

Magnetic-Field-Controlled 1D Photonic Crystal Based on a Periodic Bigyrotropic Structure

A theoretical study is reported of the magnetic-field-controlled optical transmission through a stack of identical bilayers in which one layer is bigyrotropic and the other is nonmagnetic and isotropic. An analytical expression for the complex transmittance is derived. The transmittance–wavelength characteristic is examined for different magnetizations and for fixed materials parameters and total number of bilayers. The magnetization dependence of the position, height, and width of the center peak is investigated. The effect is calculated of magnetization on the ellipticity of transmitted light and the angle of optical rotation.