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1.
It is well known that the tearing resistance curve J–Δa is not a material property. A recent approach, based on an energetic critical parameter to model ductile tearing propagation, is used to model 3D effects. The approach considered in this work aims to estimate the dissipated energy in the fracture process during ductile tearing represented by an intrinsic parameter Gfr. A fracture criterion, which accounts for the crack extension length, is defined and lies on a critical energy release rate, noted Gc, which is compared to Gfr. Previously, this parameter was obtained from a numerical local energy release rate, which handicaps the application field of the approach: a fine mesh for the whole propagation area was needed and the criterion allowed only to model 1D propagation. A new manner to estimate Gc is then proposed in this article, based on the J plastic part variation, which allows to model 2D propagation by defining a local criterion. This new calculation method is validated on a CT specimen made in Tu52b ferritic steel, by comparing the results obtained from the two methods of Gc calculation. Then, the 2D crack growth case is studied, by modelling the propagation in a ring, loaded in compression. It is shown that a 3D effect, such as tunnel effect, could be successfully represented with this approach. 相似文献
2.
Describes the development and validation of the UCLA Multidimensional Condom Attitudes Scale (MCAS). The relationships between the MCAS and gender, sexual experience, intentions to use a condom, and past condom use were assessed. The MCAS has 5 distinct factors: (1) Reliability and Effectiveness of condoms, (2) the sexual Pleasure associated with condom use, (3) the stigma attached to persons who use condoms (Identity Stigma), (4) the Embarrassment About Negotiation and Use of condoms, and (5) the Embarrassment About the Purchase of condoms. Results strongly suggest that condom attitudes are multidimensional and thus cannot meaningfully be summed to a single global score. Results further indicate that men and women hold very different attitudes toward condoms. Implications of scale multidimensionality and directions for future research are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
3.
Le Guillou Y. Gaborieau O. Gamand P. Isberg M. Jakobsson P. Jonsson L. Le Deaut D. Marie H. Mattisson S. Monge L. Olsson T. Prouet S. Tired T. 《Solid-State Circuits, IEEE Journal of》2005,40(2):403-411
This paper describes a highly digitized direct conversion receiver of a single-chip quadruple-band RF transceiver that meets GSM/GPRS and EDGE requirements. The chip uses an advanced 0.25-/spl mu/m BiCMOS technology. The I and Q on-chip fifth-order single-bit continuous-time sigma-delta (/spl Sigma//spl Delta/) ADC has 84-dB dynamic range over a total bandwidth of /spl plusmn/135 kHz for an active area of 0.4 mm/sup 2/. Hence, most of the channel filtering is realized in a CMOS IC where digital processing is achieved at a lower cost. The systematic analysis of dc offset at each stage of the design enables to perform the dc offset cancellation loop in the digital domain as well. The receiver operates at 2.7 V with a current consumption of 75 mA. A first-order substrate coupling analysis enables to optimize the floor plan strategy. As a result, the receiver has an area of 1.8 mm/sup 2/. 相似文献
4.
5.
Rabbits were fed diets enriched with cholestanol or cholestereol (3.5 g/wk) for 4–12 weeks. During cholestanol feeding, the
concentration of cholestanol in blood serum, liver, heart and aorta increased 15–30 times. In serum and liver, the concentration
of cholesterol also increased. Cholestanol-fed rabbits developed inflammatory changes in the liver, with proliferation of
small bile ducts. Liver tests were only slightly abnormal. Morphological atherosclerosis of the aorta was only occasionally
seen in rabbits receiving cholestanol for eight weeks or less.
During cholesterol feeding, the amounts of cholesterol in different tissues increased dramatically, most in the aorta. Morphological
atherosclerosis in the aorta was found in all rabbits fed cholesterol-enriched diets for more than four weeks. Brain cholestanol
was doubled in rabbits fed cholestanol for eight weeks, whereas brain sterols did not change significantly during cholesterol
feeding. After an additional regression period with cholestyramine for eight weeks, the increased content of cholestanol in
the brain was unchanged in cholestanol-fed rabbits. These observations are discussed in relation to the cholestanolosis of
the brain that develops in the rare inherited human disease cerebrotendinous xanthomatosis. 相似文献
6.
Said Ghaout Alain Louveaux Anne Marie Mainguet Max Deschamps Youssef Rahal 《Journal of chemical ecology》1991,17(8):1499-1515
A field study of the food eaten by solitary desert locusts was carried out in a winter breeding area in Mauritania. The food eaten, determined by the plant epidermis found in fecal pellets, was compared to the plant's availability in the habitat.Schouwia purpurea, well represented in the diets, was dominant at the study site. Adults had a preference forTribulus terrester. Growth and feeding on these two plants were compared. The high water content ofS. purpurea leaves limited the dry matter eaten and slowed down growth. Glucosinolates were separated and quantified by gas chromatography. There are 132mol/g dry matter in green leaves. In multiple choice tests, with paper disks, glucosinolate extracts were phagostimulant at a low concentration (21mol/g dry matter) and repulsive at a higher one (214mol/ g dry matter). Biting behavior onS. purpurea was recorded and analyzed on video. The importance ofSchouwia purpurea in desert locust habitats and its defenses is discussed. 相似文献
7.
Wenbo Zhou Julia Craft Alex Ojemann Luke Bergen Arin Graner Aitana Gonzales Qianbin He Timothy Kopper Marie Smith Michael W. Graner Xiaoli Yu 《International journal of molecular sciences》2022,23(13)
WHO Grade 4 IDH-wild type astrocytoma (GBM) is the deadliest brain tumor with a poor prognosis. Meningioma (MMA) is a more common “benign” central nervous system tumor but with significant recurrence rates. There is an urgent need for brain tumor biomarkers for early diagnosis and effective treatment options. Extracellular vesicles (EVs) are tiny membrane-enclosed vesicles that play essential functions in cell-to-cell communications among tumor cells. We aimed to identify epitopes of brain tumor EVs by phage peptide libraries. EVs from GBM plasma, MMA plasma, or brain tumor cell lines were used to screen phage-displayed random peptide libraries to identify high-affinity peptides. We purified EVs from three GBM plasma pools (23 patients), one MMA pool (10 patients), and four brain tumor cell lines. We identified a total of 21 high-affinity phage peptides (12 unique) specific to brain tumor EVs. The peptides shared high sequence homologies among those selected by the same EVs. Dose–response ELISA demonstrated that phage peptides were specific to brain tumor EVs compared to controls. Peptide affinity purification identified unique brain tumor EV subpopulations. Significantly, GBM EV peptides inhibit brain tumor EV-induced complement-dependent cytotoxicity (necrosis) in neurons. We conclude that phage display technology could identify specific peptides to isolate and characterize tumor EVs. 相似文献
8.
Within the field of Information Systems, a good proportion of research is concerned with the work organisation and this has,
to some extent, restricted the kind of application areas given consideration. Yet, it is clear that information and communication
technology deployments beyond the work organisation are acquiring increased importance in our lives. With this in mind, we
offer a field study of the appropriation of an online play space known as Habbo Hotel. Habbo Hotel, as a site of media convergence,
incorporates social networking and digital gaming functionality. Our research highlights the ethical problems such a dual
classification of technology may bring. We focus upon a particular set of activities undertaken within and facilitated by
the space—scamming. Scammers dupe members with respect to their ‘Furni’, virtual objects that have online and offline economic
value. Through our analysis we show that sometimes, online activities are bracketed off from those defined as offline and
that this can be related to how the technology is classified by members—as a social networking site and/or a digital game.
In turn, this may affect members’ beliefs about rights and wrongs. We conclude that given increasing media convergence, the
way forward is to continue the project of educating people regarding the difficulties of determining rights and wrongs, and
how rights and wrongs may be acted out with respect to new technologies of play online and offline.
Marie Griffiths moved from the IT industry into academia and is now based at the University of Salford as an EPSRC Academic Fellow. She has, and continues to research gender and ICTs. Recently she has embarked upon the study “Cybercitizens and their Virtual Pursuits” to understand the consequence of growing up and living in a technologically saturated environment. Her work has been published in journals such as Gender, Work and Organization, the European Journal of Information Systems and Information Communication and Society. Ben Light is Professor of Technology and Society at the University of Salford. His research concerns the appropriation of configurable technologies within work, organisations and society. This has led him to explore the use of large-scale enterprise resource planning packages, call centre technologies, social networking sites and digital games. He has published in journals such as Communications of the ACM, Information Systems Journal, New Technology, Work and Employment, the European Journal of Information Systems and the Journal of Information Technology. 相似文献
Ben LightEmail: |
Marie Griffiths moved from the IT industry into academia and is now based at the University of Salford as an EPSRC Academic Fellow. She has, and continues to research gender and ICTs. Recently she has embarked upon the study “Cybercitizens and their Virtual Pursuits” to understand the consequence of growing up and living in a technologically saturated environment. Her work has been published in journals such as Gender, Work and Organization, the European Journal of Information Systems and Information Communication and Society. Ben Light is Professor of Technology and Society at the University of Salford. His research concerns the appropriation of configurable technologies within work, organisations and society. This has led him to explore the use of large-scale enterprise resource planning packages, call centre technologies, social networking sites and digital games. He has published in journals such as Communications of the ACM, Information Systems Journal, New Technology, Work and Employment, the European Journal of Information Systems and the Journal of Information Technology. 相似文献
9.
Clara Savary Ccile Picard Nadge Corradini Marie Castets 《International journal of molecular sciences》2022,23(11)
Soft tissue sarcoma (STS) comprise a large group of mesenchymal malignant tumors with heterogeneous cellular morphology, proliferative index, genetic lesions and, more importantly, clinical features. Full elucidation of this wide diversity remains a central question to improve their therapeutic management and the identity of cell(s)-of-origin from which these tumors arise is part of this enigma. Cellular reprogramming allows transitions of a mature cell between phenotypes, or identities, and represents one key driver of tumoral heterogeneity. Here, we discuss how cellular reprogramming mediated by driver genes in STS can profoundly reshape the molecular and morphological features of a transformed cell and lead to erroneous interpretation of its cell-of-origin. This review questions the fact that the epigenetic context in which a genetic alteration arises has to be taken into account as a key determinant of STS tumor initiation and progression. Retracing the cancer-initiating cell and its clonal evolution, notably via epigenetic approach, appears as a key lever for understanding the origin of these tumors and improving their clinical management. 相似文献
10.
Once merely thought of as the protein responsible for the overall physical nature of the human immunodeficiency virus type 1 (HIV-1), the Gag polyprotein has since been elucidated to have several roles in viral replication and functionality. Over the years, extensive research into the polyproteins’ structure has revealed that Gag can mediate its own trafficking to the plasma membrane, it can interact with several host factors and can even aid in viral genome packaging. Not surprisingly, Gag has also been associated with HIV-1 drug resistance and even treatment failure. Therefore, this review provides an extensive overview of the structural and functional roles of the HIV-1 Gag domains in virion integrity, functionality and infectivity. 相似文献