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Dadhichi Paretkar Marleen Kamperman Andreas S. Schneider David Martina Costantino Creton Eduard Arzt 《Materials science & engineering. C, Materials for biological applications》2011,31(6):1152-1159
We developed a dry synthetic adhesive system inspired by gecko feet adhesion that can switch reversibly from adhesion to non-adhesion with applied pressure as external stimulus. Micropatterned polydimethylsiloxane (PDMS) surfaces with pillars of 30 μm length and 10 μm diameter were fabricated using photolithography and moulding. Adhesion properties were determined with a flat probe as a function of preload. For low and moderate applied compressive preloads, measured adhesion was 7.5 times greater than on flat controls whereas for high applied preloads adhesion dropped to very low values. In situ imaging shows that the increased preload caused the pillars to deform by bending and/or buckling and to lose their adhesive contact. The elasticity of PDMS aids the pillar recovery to the upright position upon removal of preload enabling repeatability of the switch. 相似文献
3.
The use of PET bottles for packaging soft drinks and mineral waters is still growing world wide. The production process for these bottles is improving constantly. These improvements are focussed on bottles with better barrier properties, higher inertness and higher heat stability. One of the factors determining the quality of PET bottles is the release of acetaldehyde into the product during storage. A literature survey was conducted on the odour and taste detection threshold of acetaldehyde in water. A method is described to rapidly determine the concentration of acetaldehyde in water up to a level of 1 μg/l. This method was used to determine the concentration of acetaldehyde in mineral water during storage in PET bottles. In still water no acetaldehyde could be found, whereas the concentration of acetaldehyde in carbonated mineral water increased steadily upon storage. Model experiments were performed to find an explanation. 相似文献
4.
The Netherlands is particularly vulnerable for the impacts of climate change on the water system. Regional water authorities, or water boards, are given an important role to design and implement specific adaptation policies and measures to manage these impacts. From the early 2000s onwards water boards are starting to adapt to climate change impacts, yet no systematic assessments exist to assess whether or not progress is being made and what explains similarities and differences across water boards. This paper aims to address these critical questions by analyzing the progress of all Dutch water boards for the period 2005–2016. We systematically collected and analyzed three consecutive water management plans for all 23 water boards in the Netherlands. We use content analysis methods to analyze progress by looking into their vulnerability and three levels of adaptation: recognition, groundwork and adaptation action. The results show that over time the number of reported climate change adaptation initiatives by the water boards is increasing, but most climate change adaptation is still at the recognition or groundwork level. Our findings reveal a diversity of efforts to adapt to climate change among Dutch water boards. We conclude that while (inter)national water and climate change adaptation policies have called for more adaptation action at regional levels, the unequal progress across the Netherlands suggests that existing ‘soft’ policy measures to push for adaptation might not be sufficient to ensure progress on adaptation across all water boards. 相似文献
5.
Marco Domp Francisco J. Cedano‐Serrano Mehdi Vahdati Larissa van Westerveld Dominique Hourdet Costantino Creton Jasper van der Gucht Thomas Kodger Marleen Kamperman 《Advanced Materials Interfaces》2020,7(4)
Many marine organisms have developed adhesives that are able to bond under water, overcoming the challenges associated with wet adhesion. A key element in the processing of several natural underwater glues is complex coacervation, a liquid–liquid phase separation driven by complexation of oppositely charged macromolecules. Inspired by these examples, the development of a fully synthetic complex coacervate‐based adhesive is reported with an in situ setting mechanism, which can be triggered by a change in temperature and/or a change in ionic strength. The adhesive consists of a matrix of oppositely charged polyelectrolytes that are modified with thermoresponsive poly(N‐isopropylacrylamide) (PNIPAM) grafts. The adhesive, which initially starts out as a fluid complex coacervate with limited adhesion at room temperature and high ionic strength, transitions into a viscoelastic solid upon an increase in temperature and/or a decrease in the salt concentration of the environment. Consequently, the thermoresponsive chains self‐associate into hydrophobic domains and/or the polyelectrolyte matrix contracts, without inducing any macroscopic shrinking. The presence of PNIPAM favors energy dissipation by softening the material and by allowing crack blunting. The high work of adhesion, the gelation kinetics, and the easy tunability of the system make it a potential candidate for soft tissue adhesion in physiological environments. 相似文献
6.
Anna M. C. Maan Anton H. Hofman Wiebe M. de Vos Marleen Kamperman 《Advanced functional materials》2020,30(32)
While nature has optimized its antifouling strategies over millions of years, synthetic antifouling coatings have not yet reached technological maturity. For an antifouling coating to become technically feasible, it should fulfill many requirements: high effectiveness, long‐term stability, durability, ecofriendliness, large‐scale applicability, and more. It is therefore not surprising that the search for the perfect antifouling coating has been going on for decades. With the discovery of metal‐based antifouling paints in the 1970s, fouling was thought to be a problem of the past, yet its untargeted toxicity led to serious ecological concern, and its use became prohibited. As a response, research shifted focus toward a biocompatible alternative: polymer‐based antifouling coatings. This has resulted in numerous advanced and innovative antifouling strategies, including fouling‐resistant, fouling‐release, and fouling‐degrading coatings. Here, these novel and exciting discoveries are highlighted while simultaneously assessing their antifouling performance and practical feasibility. 相似文献
7.
Nadja Van Camp Ruth Vreys Koen Van Laere Erwin Lauwers Dirk Beque Marleen Verhoye Cindy Casteels Alfons Verbruggen Zeger Debyser Luc Mortelmans Jan Sijbers Johan Nuyts Veerle Baekelandt Annemie Van der Linden 《Magma (New York, N.Y.)》2010,23(2):65-75
Object
In the present study, we aimed to evaluate the impact of neurodegeneration of the nigrostriatal tract in a rodent model of Parkinson’s disease on the different MR contrasts (T2, T1, CBF and CBV) measured in the striatum.Material and methods
Animals were injected with 6-hydroxydopamine (6OHDA) in the substantia nigra resulting in massive loss of nigrostriatal neurons and hence dopamine depletion in the ipsilateral striatum. Using 7T MRI imaging, we have quantified T2, T1, CBF and CBV in the striata of 6OHDA and control rats. To validate the lesion size, behavioral testing, dopamine transporter μSPECT and tyrosine hydroxylase staining were performed.Results
No significant differences were demonstrated in the absolute MRI values between 6OHDA animals and controls; however, 6OHDA animals showed significant striatal asymmetry for all MRI parameters in contrast to controls.Conclusions
These PD-related asymmetry ratios might be the result of counteracting changes in both intact and affected striatum and allowed us to diagnose PD lesions. As lateralization is known to occur also in PD patients and might be expected in transgenic PD models as well, we propose that MR-derived asymmetry ratios in the striatum might be a useful tool for in vivo phenotyping of animal models of PD. 相似文献8.
Marleen Julia Meyer Simon Falk Sarah Rmer Clarissa Prinzinger Sabine Tacke Joachim Geyer Stefan Simm Mladen Vassilev Tzvetkov 《International journal of molecular sciences》2022,23(9)
OCT1 and OCT2 are polyspecific membrane transporters that are involved in hepatic and renal drug clearance in humans and mice. In this study, we cloned dog OCT1 and OCT2 and compared their function to the human and mouse orthologs. We used liver and kidney RNA to clone dog OCT1 and OCT2. The cloned and the publicly available RNA-Seq sequences differed from the annotated exon-intron structure of OCT1 in the dog genome CanFam3.1. An additional exon between exons 2 and 3 was identified and confirmed by sequencing in six additional dog breeds. Next, dog OCT1 and OCT2 were stably overexpressed in HEK293 cells and the transport kinetics of five drugs were analyzed. We observed strong differences in the transport kinetics between dog and human orthologs. Dog OCT1 transported fenoterol with 12.9-fold higher capacity but 14.3-fold lower affinity (higher KM) than human OCT1. Human OCT1 transported ipratropium with 5.2-fold higher capacity but 8.4-fold lower affinity than dog OCT1. Compared to human OCT2, dog OCT2 showed 10-fold lower transport of fenoterol and butylscopolamine. In conclusion, the functional characterization of dog OCT1 and OCT2 reported here may have implications when using dogs as pre-clinical models as well as for drug therapy in dogs. 相似文献
9.
Dimitrios Nikolakis Floris A. E. de Voogd Maarten J. Pruijt Joep Grootjans Marleen G. van de Sande Geert R. DHaens 《International journal of molecular sciences》2022,23(3)
Although the number of therapeutic options for the treatment of inflammatory bowel disease (IBD) has increased in recent years, patients suffer from decreased quality of life due to non-response or loss of response to the currently available treatments. An increased understanding of the disease’s etiology could provide novel insights for treatment strategies in IBD. Lymphatic system components are generally linked to immune responses and presumably related to inflammatory diseases pathophysiology. This review aims to summarize findings on immune-mediated mechanisms in lymphoid tissues linked with IBD pathogenesis and (potential) novel treatments. Enhanced innate and adaptive immune responses were observed in mesenteric lymph nodes (MLNs) and other lymphoid structures, such as Peyer’s patches, in patients with IBD and in animal models. Furthermore, the phenomenon of lymphatic obstruction in the form of granulomas in MLNs and lymphatic vessels correlates with disease activity. There is also evidence that abnormalities in the lymphatic stromal components and lymph node microbiome are common in IBD and could be exploited therapeutically. Finally, novel agents targeting lymphocyte trafficking have been added to the treatment armamentarium in the field of IBD. Overall, gut-associated lymphoid tissue plays a key role in IBD immunopathogenesis, which could offer novel therapeutic targets. 相似文献
10.
Marleen Morbee Antoni Roca Josep Prades-Nebot Aleksandra Pižurica Wilfried Philips 《Signal, Image and Video Processing》2008,2(2):129-140
In some video coding applications, it is desirable to reduce the complexity of the video encoder at the expense of a more
complex decoder. Wyner–Ziv (WZ) video coding is a new paradigm that aims to achieve this. To allocate a proper number of bits
to each frame, most WZ video coding algorithms use a feedback channel, which allows the decoder to request additional bits
when needed. However, due to these multiple bit requests, the complexity and the latency of WZ video decoders increase massively.
To overcome these problems, in this paper we propose a rate allocation (RA) algorithm for pixel-domain WZ video coders. This
algorithm estimates at the encoder the number of bits needed for the decoding of every frame while still keeping the encoder
complexity low. Experimental results show that, by using our RA algorithm, the number of bit requests over the feedback channel—and
hence, the decoder complexity and the latency—are significantly reduced. Meanwhile, a very near-to-optimal rate-distortion
performance is maintained.
This work has been partially supported by the Spanish Ministry of Education and Science and the European Commission (FEDER)
under grant TEC2005-07751-C02-01.
A. Pižurica is a postdoctoral research fellow of FWO, Flanders. 相似文献