Behavioral Attestation for Web Services using access policies

Service Oriented Architecture with underlying technologies like web services and web service orchestration opens new vistas for integration among business processes operating in heterogeneous environments. However, such dynamic collaborations require a highly secure environment at each respective business partner site. Existing web services standards address the issue of security only on the service provider platform. The partner platforms to which sensitive information is released have till now been neglected. Remote Attestation is a relatively new field of research which enables an authorized party to verify that a trusted environment actually exists on a partner platform. To incorporate this novel concept in to the web services realm, a new mechanism called WS-Attestation has been proposed. This mechanism provides a structural paradigm upon which more fine-grained solutions can be built. In this paper, we present a novel framework, Behavioral Attestation for Web Services, in which XACML is built on top of WS-Attestation in order to enable more flexible remote attestation at the web services level. We propose a new type of XACML policy called XACML behavior policy, which defines the expected behavior of a partner platform. Existing web service standards are used to incorporate remote attestation at the web services level and a prototype is presented, which implements XACML behavior policy using low-level attestation techniques.     

Photo‐induced Leishmania DNA degradation by silver‐doped zinc oxide nanoparticle: an in‐vitro approach

Recently, the authors reported newly synthesised polyethylene glycol (PEG)ylated silver (9%)‐doped zinc oxide nanoparticle (doped semiconductor nanoparticle (DSN)) which has high potency for killing Leishmania tropica by producing reactive oxygen species on exposure to sunlight. The current report is focused on Leishmania DNA interaction and damage caused by the DSN. Here, we showed that the damage to Leishmania DNA was indirect, as the DSN was unable to interact with the DNA in intact Leishmania cell, indicating the incapability of PEGylated DSN to cross the nucleus barrier. The DNA damage was the result of high production of singlet oxygen on exposure to sunlight. The DNA damage was successfully prevented by singlet oxygen scavenger (sodium azide) confirming involvement of the highly energetic singlet oxygen in the DNA degradation process.Inspec keywords: silver, zinc compounds, nanoparticles, nanomedicine, DNA, microorganisms, cellular biophysics, biomedical engineeringOther keywords: photo‐induced Leishmania DNA degradation, PEGylated silver‐doped zinc oxide nanoparticle, Leishmania tropica, reactive oxygen species, sunlight, Leishmania DNA interaction, Leishmania cell, DNA damage, singlet oxygen scavenger, sodium azide, DNA degradation process, ZnO:Ag     

Formulation and characterisation of a self‐nanoemulsifying drug delivery system of amphotericin B for the treatment of leishmaniasis

This study was aimed to develop a self‐nanoemulsifying drug delivery system (SNEDDS) for amphotericin B (AmB) potential use in leishmaniasis through topical and oral routes. Two formulations, formulation A and formulation B (FA and FB) of AmB loaded SNEDDS were developed by mixing their excipients through vortex and sonication. The SNEDDS formulation FA and FB displayed a mean droplet size of 27.70 ± 0.5 and 30.17 ± 0.7 nm and zeta potential −11.4 ± 3.25 and −13.6 ± 2.75 mV, respectively. The mucus permeation study showed that formulation FA and FB diffused 1.45 and 1.37%, respectively in up to 8 mm of mucus. The cell permeation across Caco‐2 cells monolayer was 10 and 11%, respectively. Viability of Caco‐2 cells was 89% for FA and 86.9% for FB. The anti‐leishmanial activities of FA in terms of IC₅₀ were 0.017 µg/ml against promastigotes and 0.025 µg/ml against amastigotes, while IC₅₀ values of FB were 0.031 and 0.056 µg/ml, respectively. FA and FB killed macrophage harboured Leishmania parasites in a dose‐dependent manner and a concentration of 0.1 µg/ml killed 100% of the parasites. These formulations have the potential to provide a promising tool for AmB use through oral and topical routes in leishmaniasis therapy.Inspec keywords: nanomedicine, drops, microorganisms, electrokinetic effects, cellular biophysics, drug delivery systems, monolayers, drugs, diseasesOther keywords: self‐nanoemulsifying drug delivery system, topical routes, oral routes, SNEDDS formulation, mucus permeation study, cell permeation, leishmaniasis treatment, amphotericin B, zeta potential, Caco‐2 cell monolayer, vortex, sonication, droplet size, Caco‐2 cell viability, antileishmanial activity, promastigotes, amastigotes, Leishmania parasites     

Pareto Random Variables for Hydrological Modeling

Motivated by hydrological problems, the exact distributions of the sum X + Y, the product X Y and the ratio X/(X + Y) are derived when X and Y are independent Pareto random variables. A detailed application of the results is provided to extreme rainfall data from Florida.     

The distribution of sums, products and ratios for Lawrance and Lewis's bivariate exponential random variables

We derive the exact distributions of R=X+Y, P=XY and W=X/(X+Y) and the corresponding moment properties when X and Y follow Lawrence and Lewis's bivariate exponential distribution. The expressions turn out to involve special functions. We also provide extensive tabulations of the percentage points associated with the distributions. These tables—obtained using intensive computing power—will be of use to practitioners of the bivariate exponential distribution.     

Vector Based Genetic Algorithm to optimize predictive analysis in network security

A new Intrusion Detection System (IDS) for network security is proposed making use of a Vector-Based Genetic Algorithm (VBGA) inspired by evolutionary approaches. The novelty in the algorithm is to represent chromosomes as vectors and training data as matrices. This approach allows multiple pathways to calculate fitness function out of which one particular methodology is used and tested. The proposed method uses the overlap of the matrices with vector chromosomes for model building. The fitness of the chromosomes is calculated from the comparison of true and false positives in test data. The algorithm is flexible to train the chromosomes for one particular attack type or to detect the maximum number of attacks. The VBGA has been tested on two datasets (KDD Cup-99 and CTU-13). The proposed algorithm gives high detection rate and low false positives as compared to traditional Genetic Algorithm. A detailed comparative analysis is given of proposed VBGA with the traditional string-based genetic algorithm on the basis of accuracy and false positive rates. The results show that vector based genetic algorithm provides a significant improvement in detection rates keeping false positives at minimum.     

An Android runtime security policy enforcement framework

Today, smart phone’s malwares are deceptive enough to spoof itself as a legal mobile application. The front-end service of Trojans is attractive enough to deceive mobile users. Mobile users download similar malwares without knowing their illegitimate background threat. Unlike other vendors, Android is an open-source mobile operating system, and hence, it lacks a dedicated team to analyze the application code and decide its trustworthiness. We propose an augmented framework for Android that monitors the dynamic behavior of application during its execution. Our proposed architecture called Security Enhanced Android Framework (seaf) validates the behavior of an application through its permissions exercising patterns. Based on the exercised permissions’ combination, the mobile user is intimated about the dangerous behavior of an application. We have implemented the proposed framework within Android software stack and ported it to device. Our initial investigation shows that our solution is practical enough to be used in the consumer market.     

A semisynthetic fetal calf serum-free liquid medium for in vitro cultivation of Leishmania promastigotes

tmRNA (also known as 10Sa RNA) is so-named for its dual tRNA-like and mRNA-like nature. It is employed in a remarkable trans -translation process to add a C-terminal peptide tag to the incomplete protein product of a broken mRNA; the tag targets the abnormal protein for proteolysis. tmRNA sequences have been identified in genomes of diverse bacterial phyla, including the most deeply branching. They have also been identified in plastids of the 'red' lineage. The tmRNA Website (http://www.wi.mit. edu/bartel/tmRNA/home ) contains a database currently including sequences from 37 species, with provisional alignments, as well as the tentatively predicted proteolysis tag sequences. A brief review and guide to the literature is also provided.