Experimental and numerical assessment of gate-lag phenomena in AlGaAs-GaAs heterostructure field-effect transistors (FETs)

Gate-lag effects are characterized in AlGaAs-GaAs heterostructure field-effect transistors (HFETs) by means of measurements and numerical device simulations. Gate lag increasingly affects device switching at increasing ungated recess extension, suggesting that responsible deep levels be located at the ungated, recess surface of the HFET. Gate lag diminishes by making the off-state gate-source voltage less negative and by increasing the drain bias. Increasing the temperature makes the turn-on transient faster at low drain bias, while slightly delaying it at high drain bias. Numerical device simulations accounting for acceptor-like traps at the ungated surface predict gate-lag phenomena in good agreement with experiments, reproducing correctly the observed bias and temperature dependences. Simulations show that surface states behave, during the turn-on transient, as hole traps capturing holes attracted at the ungated surface by the negative trapped charge.     

Gquest: Modeling patient questionnaires and administering them through a mobile platform application

Background

The use of surveys is becoming popular in the health care industry for acquiring information useful to the accomplishment of several studies. Besides their exploitation on a large scale for conducting epidemiological studies, surveys are being increasingly carried out on a narrower perspective through the administration of questionnaires aimed at assessing the quality of life perceived by patients or their clinical status during mid- or long-term treatments. This is useful for managing resources or optimizing and individualizing treatments.

Objectives

This paper describes Gquest, a platform for modeling, generating and administering questionnaires through mobile devices such as smartphones or tablets. Gquest was motivated by the need of administering questionnaires during home treatments, albeit its applicability is rather general. The main requirement was to have a very simple, clean and easy to use platform able to support (a) physicians in the design and delivery of questionnaires and (b) outpatients in sending self-recorded outcomes to the clinical staff.

Methods

Gquest has two basic components. The first one is a model devised for representing questionnaires which is extremely flexible. It allows the generation of questions and answers of different types, supports adaptivity in the dialog with the user and enforces simple consistency rules for checking his input. The second component is an application able to run instances of those questionnaires. It downloads questionnaires over the air in terms of XML files from a server and stores them locally into the mobile repository. Questionnaires become then available to the user, who in our case is a patient or one of his relatives. The user can select which one to fill-in, according to his needs and/or the specific treatment protocol. The selected questionnaire may be filled-in all at once or be completed in subsequent steps over time since any input provided is persisted on a local database. Finally, when a questionnaire is closed all the answers are transparently synchronized to a server for further evaluation or statistical purposes.

Results

The platform has been exploited and tested in two medical domains where questionnaires have very different purposes; a quality of life pilot survey involving patients with atrial fibrillation within the EU-funded project MobiGuide, and an investigation of the users’ needs during the requirements elicitation phase of a telemedicine project for the safe discharge of fragile patients.

Conclusions

Gquest proved to be a suitable tool for dealing with a wide variety of question types and has been positively accepted by the patients enrolled in the pilot study.     

Plasmon hybridization engineering in self-organized anisotropic metasurfaces

Nano Research - The engineering of self-organized plasmonic metasurfaces is demonstrated using a maskless technique with defocused ion-beam sputtering and kinetically controlled deposition. The...     

Application of the Kalman filter for electrical endurancecharacterization of insulating materials and systems

The Kalman filter algorithm is applied to the results of accelerated life tests performed on insulating materials and systems carried out for electrical endurance characterization purposes. It consists of a recursive procedure that applies to the failure-time percentiles obtained from life tests, on the basis of the inverse power or the exponential models, and provides estimates of the endurance indices which give particular weight to the results of the life tests performed at the lowest test stresses. This allows more meaningful endurance characterization and accurate life prediction. This paper provides the algorithms for Kalman filter applications, giving emphasis to error estimation, as well as the method for calculation of confidence limits of life-line parameters and predicted failure times. The proposed Kalman filter procedure is applied to the experimental results of accelerated life tests relevant to different insulating materials and systems     

A New Approach to the Statistical Enlargement Law for Comparing the Breakdown Performance of Power Cables. 1. Theory

This paper, the first of two companion papers, describes a new approach to the application of the statistical "enlargement law" to power cable insulation. The results of this work allow for selecting better insulation for medium or high voltage cables. The selection is based on the results of dielectric strength tests performed on cable models or full size cables of a limited length. The relevance of the so-called crossing length, where one insulating compound performs better below it and another compound above this length, is discussed. The proposed theory was used to analyze the performances of two ethylene-propylene rubber (EPR) compounds and two cross-linked polyethylene (XLPE) compounds. The results are presented in the companion paper.     

Involvement of the skull base and vault in chronic idiopathic hyperphosphatasia

OBJECTIVE: To evaluate whether mutation in the exon 10 of the fibroblast growth factor receptor 3(FGFR3) gene in common in Chinese patients with achondroplasia. METHODS: Genomic DNA from seven sporadic cases of achondroplasia was studied by using PCR-SSCP and restriction enzymes. RESULTS: All patients carried the same glycine-to-arginine mutation at codon 380(G380R) of the transmembrane domain of FGFR3. CONCLUSION: The results suggest that the G380R mutation of FGFR3 is also a frequent mutation causing achondroplasia in Chinese. Detecting FGFR 3 gene mutation with PCR-SSCP and restriction enzymes analysis is a convenient, rapid and reliable molecular diagnostic assay for prenatal and early diagnosis of achondroplasia.     

SCIDDICA-SS3: a new version of cellular automata model for simulating fast moving landslides

Cellular Automata (CA) are discrete and parallel computational models useful for simulating dynamic systems that evolve on the basis on local interactions. Some natural events, such as some types of landslides, fall into this type of phenomena and lend themselves well to be simulated with this approach. This paper describes the latest version of the SCIDDICA CA family models, specifically developed to simulate debris-flows type landslides. The latest model of the family, named SCIDDICA-SS₃, inherits all the features of its predecessor, SCIDDICA-SS₂, with the addition of a particular strategy to manage momentum. The introduction of the latter permits a better approximation of inertial effects that characterize some rapid debris flows. First simulations attempts of real landslides with SCIDDICA-SS₃ have produced quite satisfactory results, comparable with the previous model.     

The tensor apparatus in double-orifice mitral valve: interpretation of echocardiographic findings

Carboxylesterases (EC 3.1.1.1) from human liver were purified using Q-Sepharose, Sephadex G-150, isoelectrofocusing and Con A-Sepharose. The calculated molecular mass of the pI 5.3 enzyme was 120 kDa and 61 kDa from the results of Sephadex G-150 gel filtration and SDS-polyacrylamide gel electrophoresis (PAGE), respectively, suggesting that this enzyme is a dimer. On the other hand, carboxylesterase pI 4.5, with a molecular mass of 64 kDa, was a monomer. The activities of both enzymes were inhibited by typical serine enzyme inhibitors. Amino acid sequence analysis of the purified enzymes pI 5.3 and 4.5 showed high homology with rabbit carboxylesterase form 1 and 2, respectively. The results also suggested that carboxylesterase pI 5.3 is identical to the deduced amino acid sequence from cDNA for HU1, and that carboxylesterase pI 4.5 is identical to the deduced amino acid sequence from the cDNA registered as human carboxylesterase (hCE-2) in GenBank. We first purified carboxylesterase pI 4.5 and investigated its hydrolytic activity upon various drugs. The two enzymes differed in substrate specificity. Prodrugs of angiotensin-converting enzyme inhibitors, such as delapril and imidapril, were converted to active metabolites by carboxylesterase pI 5.3, but not by carboxylesterase pI 4.5. The hydrolysis velocity of temocapril by carboxylesterase pI 5.3 was 12-fold faster than by carboxylesterase pI 4.5. In contrast, aspirin, oxybutynin and procaine were hydrolyzed by only carboxylesterase pI 4.5. We also found that an amide-linkage in drugs, except for that in aniracetam, was not a good substrate for the two enzymes. Consequently, carboxylesterases pI 5.3 and 4.5 may be involved in the metabolism of various drugs containing an ester-linkage.     

Identification of a Ser857-Asn857 substitution in DRK1 (KCNB1), population frequencies and lack of association to the low voltage alpha EEG trait

Human neuroblastoma cells frequently show amplification of the oncogene MYCN, which maps to 2p24. Previous studies have localized the DEAD box motif gene DDX1 to the same chromosome band and demonstrated coamplification of DDX1 and MYCN in two retinoblastoma cell lines. Recently, a high frequency of coamplification of DDX1 and MYCN has been shown in human neuroblastoma cells. We have determined the physical distance between the two genes by pulsed field gel electrophoresis in normal tissue and have found that DDX1 maps to a position at a maximum distance of 400 kbp 5' to MYCN. Two neuroblastoma cell lines with coamplification of DDX1/MYCN showed a similar topographic relationship of the two genes. In contrast, in two cell lines with high copy number, the DDX1 gene was not present in all amplified units recognized by MYCN and had changed its position in the amplified DNA relative to MYCN from 5' to 3', presumably by rearrangement during the amplification process. Our data show that the high frequency of DDX1 coamplification is due to its close physical distance to MYCN. Although amplification has resulted in an elevated expression of DDX1 the significance of overexpression for neuroblastoma remains unclear.     

Fine mapping of the Darier's disease locus on chromosome 12q

Darier's disease (DD) is an autosomal dominant genodermatosis characterized by epidermal acantholysis and dyskeratosis. We have performed genetic linkage studies in 10 families with DD (34 affected) by analyzing 14 polymorphic microsatellite markers. Our results confirm recent reports mapping the DD gene to chromosome 12q23-q24.1. Haplotype analysis of recombinant chromosomes in our families, along with previously reported data, narrow the location of the DD gene to a 5 cM interval flanked by the loci D12S354 and D12S84/D12S105. This localization allowed exclusion of two known genes, PLA2A and PAH, as candidate loci for DD. Three other gene loci (PPP1C, PMCH, PMCA1), mapping in 12q21-q24, remain potential candidates.