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排序方式: 共有646条查询结果,搜索用时 15 毫秒
1.
Jennie O'Loughlin Silvia Napolitano Fahad Alkhathami Cillian O'Beirne Daniel Marhöfer Megan O'Shaughnessy Prof. Orla Howe Prof. Matthias Tacke Dr. Marina Rubini 《Chembiochem : a European journal of chemical biology》2021,22(6):1093-1098
Antibiotic resistance is a growing problem for public health and associated with increasing economic costs and mortality rates. Silver and silver-related compounds have been used for centuries due to their antimicrobial properties. In this work, we show that 1,3-dibenzyl-4,5-diphenyl-imidazol-2-ylidene silver(I) acetate/NHC*-Ag-OAc (SBC3) is a reversible, high affinity inhibitor of E. coli thioredoxin reductase (TrxR; Ki=10.8±1.2 nM). Minimal inhibition concentration (MIC) tests with different E. coli and P. aeruginosa strains demonstrated that SBC3 can efficiently inhibit bacterial cell growth, especially in combination with established antibiotics like gentamicin. Our results show that SBC3 is a promising antibiotic drug candidate targeting bacterial TrxR. 相似文献
2.
Pietromonaco Paula R.; Rook Karen S.; Lewis Megan A. 《Canadian Metallurgical Quarterly》1992,63(2):247
Addressed conflicting views of depressives' interpersonal accuracy in an investigation of the accuracy of mild depressives (dysphorics) across differing social contexts. Women who were either friends or strangers and who were either similar or dissimilar in level of dysphoria conversed about 3 topics: a neutral topic, their own disclosure of a personal problem, and their partner's disclosure. Dysphorics were not more accurate in general than nondysphorics. After self-disclosure, all women more accurately detected sympathy from a similar stranger. After the partner's disclosure, women also better detected the mood of a similar partner. When interacting with nondysphoric strangers, however, dysphorics underestimated their partner's sympathy toward them. Implications for cognitive and interpersonal theories of depression and for depressives' relationships are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
3.
Devenport Jill A.; Patterson Megan R.; Devenport Lynn D. 《Canadian Metallurgical Quarterly》2005,119(3):352
The variability of most environments taxes foraging decisions by increasing the uncertainty of the information available. One solution to the problem is to use dynamic averaging, as do some granivores and carnivores. Arguably, the same strategy could be useful for grazing herbivores, even though their food renews and is more homogeneously distributed. Horses (Equus callabus) were given choices between variable patches after short or long delays. When patch information was current, horses returned to the patch that was recently best, whereas those without current information matched choices to the long-term average values of the patches. These results demonstrate that a grazing species uses dynamic averaging and indicate that, like granivores and carnivores, they can use temporal weighting to optimize foraging decisions. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
4.
Huang Y. Palaniappan K. Zhuang X. Cavanaugh J.E. 《IEEE transactions on pattern analysis and machine intelligence》1995,17(12):1177-1190
Optic flow motion analysis represents an important family of visual information processing techniques in computer vision. Segmenting an optic flow field into coherent motion groups and estimating each underlying motion is a very challenging task when the optic flow field is projected from a scene of several independently moving objects. The problem is further complicated if the optic flow data are noisy and partially incorrect. In this paper, the authors present a novel framework for determining such optic flow fields by combining the conventional robust estimation with a modified genetic algorithm. The baseline model used in the development is a linear optic flow motion algorithm due to its computational simplicity. The statistical properties of the generalized linear regression (GLR) model are thoroughly explored and the sensitivity of the motion estimates toward data noise is quantitatively established. Conventional robust estimators are then incorporated into the linear regression model to suppress a small percentage of gross data errors or outliers. However, segmenting an optic flow field consisting of a large portion of incorrect data or multiple motion groups requires a very high robustness that is unattainable by the conventional robust estimators. To solve this problem, the authors propose a genetic partitioning algorithm that elegantly combines the robust estimation with the genetic algorithm by a bridging genetic operator called self-adaptation 相似文献
5.
Kehoe Priscilla; Shoemaker William J.; Triano Laura; Callahan Megan; Rappolt Gabrielle 《Canadian Metallurgical Quarterly》1998,112(1):116
Adult rats that were isolated from the mother and nest for 1 hr per day from Postnatal Day 2 to 9 were studied. Controls consisted of handled littermates as well as separate litters that were never handled. As adults, animals were given either a pharmacological challenge (1.0 or 2.0 mg/kg amphetamine) or an environmental challenge (restraint). Previously isolated animals demonstrated increased activity compared to controls at both drug doses. Similarly, isolated animals manifested exaggerated inhibition of activity after restraint. Previously isolated animals usually did not show differences compared to controls under baseline conditions (saline injection or no restraint). The neuroplastic changes that result from the neonatal experience are long lasting and appear when the system is challenged. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
6.
Liu Xinke Kao Evan Haraldsson Henrik Ballweber Megan Martin Alastair Li Youxiang Wang Yuting Saloner David 《Magma (New York, N.Y.)》2021,34(5):659-666
Magnetic Resonance Materials in Physics, Biology and Medicine - To determine the intra-individual flow variation in serially acquired studies, and the influence of this variation on subsequent... 相似文献
7.
Janina Wirth Kory K. Green Megan O'Connor Shuang F. Lim 《Small (Weinheim an der Bergstrasse, Germany)》2017,13(6)
Upconverting nanoparticles show potential applications in the field of photovoltaics and array‐based detection devices. While fluorescence enhancement using interference of incident radiation is well known in Stokes‐shift type systems such as fluorescent dyes; the effect of such interference geometry in nonlinear Anti‐Stokes type emission, such as in upconversion rare earth photophysics is demonstrated for the first time. This work describes in detail the influence of the interference modulation on both the excitation (interion energy transfer) and radiative decay with nonradiative decay processes active between emissive levels. These effects are illustrated in the thickness dependence of the decay rate and rise time. Single particle upconverted spectra and time‐resolved measurements show concurrent optimization of the infrared absorption and emission at 540 and 650 nm, with an average enhanced emission of 20 times at λ = 540 and 45 times at λ = 650 nm, dependent on the interference layer thickness and on the excitation intensity. The experimental results are correlated with finite element modeling. Both experiments and calculations show emission enhancement at an interference layer thickness of about 740 ± 20 nm, where such tolerance and the planar design, leads to ease in implementation in applications. 相似文献
8.
Derrick K. Rollins Nidhi Bhandari Jim Kleinedler Kaylee Kotz Amber Strohbehn Lindsay Boland Megan Murphy Dave Andre Nisarg Vyas Greg Welk Warren E. Franke 《Journal of Process Control》2010,20(1):95-107
The goal of this work is to present a causation modeling methodology with the ability to accurately infer blood glucose levels using a large set of highly correlated noninvasive input variables over an extended period of time. These models can provide insight to improve glucose monitoring, and glucose regulation through advanced model-based control technologies. The efficacy of this approach is demonstrated using real data from a type 2 diabetic (T2D) subject collected under free-living conditions over a period of 25 consecutive days. The model was identified and tested using eleven variables that included three food variables as well as several activity and stress variables. The model was trained using 20 days of data and validated using 5 days of data. This gave a fitted correlation coefficient of 0.70 and an average absolute error (AAE) (i.e., the average of the absolute values for the measured glucose concentration minus modeled glucose concentration) of 13.3 mg/dL for the validation data. This AAE result was significantly better than the subject’s personal glucose meter AAE of 15.3 mg/dL for replicated measurements. 相似文献
9.
通过去趋势波动分析(DFA)研究驾驶员疲劳状态的心率变异性信号和脑电信号特征.22名被试在驾驶模拟器上进行模拟驾驶作业,采集驾驶过程中的心率变异性和脑电信号并进行离线分析.Wil-coxon符号秩检验用于分析清醒和疲劳两种状态间DFA标度指数的差异,受试者工作曲线(ROC)分析用于确定DFA区分疲劳驾驶和清醒驾驶的能力.结果表明:疲劳状态时,心率变异性和脑电信号的标度指数显著增加(Wilcoxon符号秩检验,p<0.01);心率变异性和脑电信号标度指数的ROC下面积最大分别为0.75和0.78.DFA的标度指数具有应用于驾驶疲劳监测系统的前景. 相似文献
10.
This research proposes a spatial optimization problem over a multi-modal transportation network, termed the q-Ad-hoc hub location problem (AHLP), to utilize alternative hubs in an ad-hoc manner in the wake of a hub outage. The model aims to reorganize the spatial structure of disrupted networks: unaffected hubs are utilized as ad-hoc hubs through which alternative routes connect supply and demand nodes. As a case study, the AHLP is applied to a multi-modal freight transport system connecting international destinations with the United States. The models are utilized to establish a new ranking methodology for critical infrastructure by combining metrics capturing nodal criticality and network resilience and recuperability. The results show that the AHLP is both an effective and practical recovery approach for a hub network to respond to the potential disruptions of hubs and a novel methodology for ranking critical infrastructure. 相似文献