Effects of metritis treatment strategies on health,behavior, reproductive,and productive responses of Holstein cows

Our objectives were to compare the effects of ceftiofur crystalline free acid (CCFA) and ampicillin trihydrate (AMP) treatments of cows diagnosed with metritis on uterine health, behavior, reproductive, and productive responses. A controlled randomized clinical trial was designed. Metritis was defined as vaginal discharge (VD) = 5 (fetid, watery, red/brown) within 21 d in milk (DIM) and rectal temperature (RT) <39.5°C, whereas VD = 5 and RT ≥39.5°C was defined as puerperal metritis. On the day of diagnosis (d 0), cows were paired by parity and severity of metritis (metritis vs. puerperal metritis) and assigned randomly to the AMP and CCFA treatments. Cows enrolled in the AMP (n = 308) treatment were moved to a nonsalable-milk pen, where they were treated once daily for 5 d, and were moved back to their original pen 72 h after the last treatment (d 7). Cows enrolled in the CCFA (n = 310) treatment remained in their original pen and received 2 treatments of CCFA, 72 h apart. Rectal temperature was measured daily from d 0 to 6 and on d 11. Vaginal discharge was evaluated on d 4, 6, and 11 to assess cure. Cure was defined as the absence of treatment with additional antimicrobial before experiment d 11, VD <5, and RT <39.5°C. Cows were examined at 28 ± 3 DIM for purulent VD (PVD) and at 35 ± 3 DIM for cytological endometritis. Pregnancy was diagnosed at 40 ± 3 and 60 ± 7 d after first and second artificial inseminations. Cure of metritis did not differ between treatments on d 11 (AMP = 64.6 ± 3.1, CCFA = 63.5 ± 3.1%). Cows treated with AMP had greater RT from experiment d 1 to 6 compared with cows treated with CCFA (AMP = 39.1 ± 0.02, CCFA = 39.0 ± 0.02°C). Cows in the AMP treatment had greater prevalence of PVD at 28 ± 3 DIM (AMP = 82.6 ± 2.3, CCFA = 74.4 ± 2.7%) and tended to have greater prevalence of cytological endometritis at 35 ± 3 DIM (AMP = 77.8 ± 6.2 vs. CCFA = 61.7 ± 7.5%) than CCFA-treated cows. Treatment did not affect the hazard of pregnancy among multiparous cows; however, among primiparous cows, CCFA treatment reduced the hazard of pregnancy and increased the median days to pregnancy (AMP = 145 vs. CCFA = 169 d). Finally, average daily milk yield up to 14 wk postpartum was not affected by treatment (AMP = 38.0 ± 0.4, CCFA = 37.5 ± 0.4 kg). We conclude from the current experiment that CCFA was more effective in reducing RT and improving uterine health of metritic cows; however, the improved hazard of pregnancy of primiparous cows treated with AMP is important and warrants further investigation.     

Rejoinder to "Validities, Vectors, and Verities" by Marvin D. Dunnette and Wayne K. Kirchner.

(See 37: 3088) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Waveform-synthesis method that reduces battery power in an electrically small wideband radiating system

An electrically small antenna is extremely inefficient when operating over a large (multi-octave) bandwidth in a conventional radiating system. As a result, a large amount of prime battery power would be needed to generate sufficient radio frequency (RF) signal power to overcome the poor antenna efficiency and to induce the desired amount of radiation. An alternative method is described in which electronic switches are integrated within a small loop antenna. The switches operate at a rate greater than the RF carrier frequency and are used to synthesise the desired RF current waveform that passes through the loop. This switching circuit replaces the power amplifier in a conventional radiating system. The battery power needed to stimulate a given radiated signal strength is significantly less [a factor of 1/10 at very high frequency (VHF)] compared with the traditional wideband power amplifier/antenna system. The performance of a prototype VHF system is described.     

The predictive efficiency of temperament characteristics and personal history variables in determining success of life insurance agents.

How can you tell who will make a good life insurance salesman? A standardized personality inventory and a locally constructed questionnaire were used in a study of 522 financed male agents employed full time in selling life insurance 3 years after hire. Those who saw themselves as being passive and submissive were likely to fail. Some personality history measures are valid predictors. Combining both measures was found to work best. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Rebuttal to and constructive comments on "Construct validity of the MacAndrew Alcoholism Scale."

Responds to a claim by M. F. Schwartz and J. R. Graham (see record 1980-02442-001) that they have further established the construct validity of the MacAndrew Alcoholism Scale (MAC). Several questions are raised regarding the design of the study and treatment of the data on which conclusions are drawn. It is proposed that the major problem rests with the discrete dichotomous nature of the response categories of the MAC and the improper analysis of the response data in the study being critiqued. (9 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Current status of graduate education in psychology.

Surveyed chairmen of psychology departments in 32 state universities and 9 private universities offering doctoral-level programs in basic and applied psychology, to determine the extent to which education and training is available for graduate students in the applied areas of psychology, specifically clinical psychology. Results indicate the following: (a) For all practical purposes, the PhD degree is the only doctoral degree being awarded in both basic and applied psychology. (b) The majority of the departments offering advanced graduate work in psychology insist on a variable core of required courses. (c) The comprehensive examinations taken by students in these programs are largely broad and integrative and are more likely to be administered by either a departmental examining committee or the student's own program committee. (d) For those departments in which a core of courses is not required of all doctoral students, there are substitute requirements, including demonstration of competencies and knowledge in content areas through examinations, or in the successful completion of a minor academic area. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Failure of clinical cure in dairy cows treated for metritis is associated with reduced productive and reproductive performance

Objectives were to assess reproductive and productive outcomes associated with failure of clinical cure in dairy cows diagnosed with metritis following antimicrobial therapy. This retrospective cohort study included data from 3 experiments performed in 5 dairies. Metritis was characterized by the presence of watery, fetid, reddish-brownish vaginal discharge within 21 DIM (study d 0). Cows not diagnosed with metritis (i.e., cows may have had other diseases postpartum; NoMT; n = 1,194) were paired based on lactation number and calving date. All cows with metritis received antimicrobial therapy (ampicillin or ceftiofur). Clinical cure was evaluated on d 10 based on vaginal discharge score, and cows were categorized as cured (MTC; n = 1,111) or not cured (MTnoC; n = 299). Purulent vaginal discharge (28 ± 3 or 32 ± 3 DIM), cytological endometritis (35 ± 3 or 39 ± 3 DIM), and estrous cyclicity (50 ± 3 and 64 ± 3, 36 ± 3 and 50 ± 3, or 37 ± 5 and 51 ± 5 DIM) were evaluated in subgroups of cows. Proportions of cows with purulent vaginal discharge and cytological endometritis were greatest for MTnoC (91.7 and 91.4%), intermediate for MTC (74.0 and 73.3%), and smallest for NoMT (38.1 and 36.4%). Proportion of cyclic cows was smaller for MTnoC compared with MTC and NoMT (62.0, 71.0, and 71.0%). Pregnancy per artificial insemination following first service was smaller for cows with metritis compared with their counterparts with no metritis (NoMT = 28.1, MTC = 26.1, MTnoC = 22.0%). Pregnancy loss tended to be greater for MTnoC compared with MTC (NoMT = 11.5, MTC = 11.1, MTnoC = 18.4%). Hazard of pregnancy by 300 DIM was smallest for MTnoC, intermediate for MTC, and greatest for NoMT. Death by 60 DIM (3.9, 1.1, and 0.6%) and removal from herd by 300 DIM (26.3, 17.4, and 15.4%) were greatest for MTnoC compared with MTC and NoMT, respectively. Milk production among multiparous cows was smaller for MTnoC compared with MTC and NoMT in the first 10 mo postpartum, whereas MTC produced less milk compared with NoMT only during the first 2 mo postpartum (NoMT = 42.0 ± 0.22, MTC = 40.6 ± 0.28, MTnoC = 37.7 ± 0.54 kg/d). Failure of clinical cure was not associated with milk yield in primiparous cows (NoMT = 35.2 ± 0.31, MTC = 33.9 ± 0.31, MTnoC = 35.0 ± 0.52 kg/d). Cows diagnosed with metritis that do not undergo clinical cure by 10 d of onset of antimicrobial therapy have impaired reproductive performance, reduced milk production, and increased risk of leaving the herd.     

Epstein-Barr virus-associated post-transplant lympho-proliferative disease of donor origin in liver transplant recipients

BACKGROUND/AIMS: Post-transplant lymphoproliferative disease, a potential complication of solid organ transplantation, occurs in about 3% of orthotopic liver transplant recipients. We report the genetic and virological characterization of two cases of post-transplant lymphoproliferative disease that occurred early (4 and 6 months) after orthotopic liver transplant as large-cell non-Hodgkin's lymphomas located at the hepatic hilum. METHODS: Lymphomatous tissues were analyzed for clonality and presence of Epstein-Barr virus (EBV) sequences by Southern blot, polymerase chain reaction, and in situ hybridization techniques. RESULTS: The tumors in both cases were sustained by a clonal proliferation of B lymphocytes containing type A EBV DNA. Moreover, in situ hybridization with a digoxigenin-labeled EBV-specific probe evidenced a strong nuclear signal in most of the neoplastic cells. DNA microsatellite analysis at three different loci detected alleles of donor origin in both tumor samples, suggesting that the neoplastic B cells were of donor origin. CONCLUSIONS: EBV-infected donor B lymphocytes might be responsible for intragraft post-transplant lymphoproliferative disease in orthotopic liver transplant recipients. As 20 to 30% of post-transplant lymphomas involve the graft itself, donor-derived post-transplant lymphoproliferative disease might be more frequent than presently appreciated. Prospective studies are needed to assess its real incidence and identify possible risk factors.