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1.
L Giorgi A Di Filippo A Franchini L Rizzo S Benvenuti M Conti GP Novelli 《Canadian Metallurgical Quarterly》1994,60(1-2):43-47
OBJECTIVE: The reflex response to orotracheal intubation provokes an increase of arterial pressure accompanied by an increase of chorioides volume and a consequent ocular hypertone. There are several methods to reduce the reflex response due to intubation. One of the most effective is topical anaesthesia of larynx and trachea. Experiments were directed to evaluate the efficacy of topical anaesthesia to reduce the intraocular hypertone due to orotracheal intubation. DESIGN: A prospective randomized mask study was conduct on patients undergoing ophthalmologic (anterior segment) surgery at the Eye Clinic of Florence University. METHODS: Intraocular pressure was measured by a Goldman tonometer at four times: T0 = basal, T1 = 2' minutes after induction of general anaesthesia, T2 = 2' minutes after laryngoscopy, T3 = 2' minutes after orotracheal intubation. At the same moments, systolic blood pressure, heart rate, rate pressure pro duct were measured. Patients were randomly divided in two groups: Group L (n = 10) in which was evaluated the efficacy of laryngotracheal topical spray of lidocaine 4% (2 ml) and Group F (n = 10) in which saline was used instead of anesthetic. The filling of the LTA kit (Abbott) was made by a person not involved in the experiments. DATA ANALYSIS: Student's t test for unpaired data. RESULTS: Topical anaesthesia reduces the increase of intraocular pressure, hypertension and rate pressure product due to intubation. The intraocular pressure reduces to 13% less than basal value in Group L and increase to 50% more than basal value in Group F. CONCLUSION: The topical anaesthesia of larynx and trachea is effective to reduce the intraocular hypertension due to the reflex response evoked by orotracheal intubation. 相似文献
2.
R Zanardi L Franchini M Gasperini E Smeraldi J Perez 《Canadian Metallurgical Quarterly》1997,12(4):195-197
The aim of this open pilot study was to evaluate the efficacy of fluvoxamine in the continuation as well as in the maintenance therapy of delusional depression. Thirty patients with recurrent, unipolar depression (DSM-IV criteria) were selected who had at least one depressive episode during the 18 months preceding the delusional depressive index episode and were treated with fluvoxamine 300 mg/day. Twenty-five of them had a sustained response to this short-term treatment and agreed to enter into the 30-month follow up study. All participants completed the follow up period. No relapse was observed during the 6 months of continuation therapy. During the further 24 months of maintenance therapy, 80% of the patients remained well, whereas 20% (five out of 25) had a single recurrence. Based on these observations, fluvoxamine might be a promising drug for long-term therapy of delusional depression. Further controlled studies are required to confirm this finding. 相似文献
3.
Prof. Alessia Carocci Dr. Mariagrazia Roselli Prof. Roberta Budriesi Dr. Matteo Micucci Prof. Jean-François Desaphy Dr. Concetta Altamura Dr. Maria Maddalena Cavalluzzi Dr. Maddalena Toma Dr. Giovanna Ilaria Passeri Dr. Gualtiero Milani Dr. Angelo Lovece Prof. Alessia Catalano Dr. Claudio Bruno Dr. Annalisa De Palma Prof. Filomena Corbo Prof. Carlo Franchini Prof. Solomon Habtemariam Prof. Giovanni Lentini 《ChemMedChem》2021,16(3):578-588
Under the hypothesis that cardioprotective agents might benefit from synergism between antiarrhythmic activity and antioxidant properties, a small series of mexiletine analogues were coupled with the 2,2,5,5-tetramethylpyrroline moiety, known for its antioxidant effect, in order to obtain dual-acting drugs potentially useful in the protection of the heart against post-ischemic reperfusion injury. The pyrroline derivatives reported herein were found to be more potent as antiarrhythmic agents than mexiletine and displayed antioxidant activity. The most interesting tetramethylpyrroline congener, a tert-butyl-substituted analogue, was at least 100 times more active as an antiarrhythmic than mexiletine. 相似文献
4.
Serena Montalbano Francesca Degola Jennifer Bartoli Franco Bisceglie Annamaria Buschini Mauro Carcelli Donatella Feretti Serena Galati Laura Marchi Nicol Orsoni Giorgio Pelosi Marianna Pioli Francesco M. Restivo Dominga Rogolino Mirco Scaccaglia Olga Serra Giorgio Spadola Gaia C. V. Viola Ilaria Zerbini Claudia Zani 《International journal of molecular sciences》2021,22(9)
The control of the fungal contamination on crops is considered a priority by the sanitary authorities of an increasing number of countries, and this is also due to the fact that the geographic areas interested in mycotoxin outbreaks are widening. Among the different pre- and post-harvest strategies that may be applied to prevent fungal and/or aflatoxin contamination, fungicides still play a prominent role; however, despite of countless efforts, to date the problem of food and feed contamination remains unsolved, since the essential factors that affect aflatoxins production are various and hardly to handle as a whole. In this scenario, the exploitation of bioactive natural sources to obtain new agents presenting novel mechanisms of action may represent a successful strategy to minimize, at the same time, aflatoxin contamination and the use of toxic pesticides. The Aflatox® Project was aimed at the development of new-generation inhibitors of aflatoxigenic Aspergillus spp. proliferation and toxin production, through the modification of naturally occurring molecules: a panel of 177 compounds, belonging to the thiosemicarbazones class, have been synthesized and screened for their antifungal and anti-aflatoxigenic potential. The most effective compounds, selected as the best candidates as aflatoxin containment agents, were also evaluated in terms of cytotoxicity, genotoxicity and epi-genotoxicity to exclude potential harmful effect on the human health, the plants on which fungi grow and the whole ecosystem. 相似文献
5.
Marco Franchini 《Water Resources Management》1994,8(3):225-238
With reference to the kinematic wave theory coupled with the hypothesis of constant linear velocity for the rating curve, rising limb analytical solutions have been calculated for overland flow, over an Hortonian-infiltrating surface, and sediment discharge. These analytical solutions are certainly easier to use than the numerical integration of the basic equations and they may be used to obtain an initial evaluation of the parameters of more complex models generally devised for complicated cases.Notation
a
exponent of the Horton law [T–1]
-
b
exponent of the rill erosion equation
-
B
inter-rill erosion coefficient [ML–m–2T
m–1]
-
c
sediment concentration [ML–3]
-
c
o
reference sediment concentration [ML–3]
-
E
I
inter-rill erosion [ML–2T–1]
-
E
R
rill erosion [ML–2T–1]
-
f
c
final infiltration rate of the soil [LT–1]
-
f
o
initial infiltration rate of the soil [LT–1]
-
h
flow depth [L]
-
h
o
reference flow depth [L]
-
i
infiltration rate [LT–1]
-
k
rill erosion coefficient [ML–1–b
T–1]
-
K
integration constant
-
L()
Laplace transformation
-
m
exponent of the inter-rill erosion equation
-
n
Manning's coefficient [L–1/3T]
-
p
rainfall intensity [LT–1]
-
q
water discharge per unit width [L2T–1]
-
q
s
sediment discharge per unit width [ML–1T–1]
-
t
time [T]
-
t
p
ponding time [T]
-
x
distance along the flow direction [L]
Greek Letters
coefficient of the stage-discharge equation [L2–T–1]
-
exponent of the stage-discharge equation
-
rill erosion coefficient [L–1] 相似文献
6.
Stephen Gilmore L��szl�� G?nczy Nora Koch Philip Mayer Mirco Tribastone D��niel Varr�� 《Software and Systems Modeling》2011,10(3):287-311
Systems based on the service-oriented architecture (SOA) principles have become an important cornerstone of the development
of enterprise-scale software applications. They are characterized by separating functions into distinct software units, called
services, which can be published, requested and dynamically combined in the production of business applications. Service-oriented
systems (SOSs) promise high flexibility, improved maintainability, and simple re-use of functionality. Achieving these properties
requires an understanding not only of the individual artifacts of the system but also their integration. In this context,
non-functional aspects play an important role and should be analyzed and modeled as early as possible in the development cycle.
In this paper, we discuss modeling of non-functional aspects of service-oriented systems, and the use of these models for
analysis and deployment. Our contribution in this paper is threefold. First, we show how services and service compositions
may be modeled in UML by using a profile for SOA (UML4SOA) and how non-functional properties of service-oriented systems can
be represented using the non-functional extension of UML4SOA (UML4SOA-NFP) and the MARTE profile. This enables modeling of
performance, security and reliable messaging. Second, we discuss formal analysis of models which respect this design, in particular
we consider performance estimates and reliability analysis using the stochastically timed process algebra PEPA as the underlying
analytical engine. Last but not least, our models are the source for the application of deployment mechanisms which comprise
model-to-model and model-to-text transformations implemented in the framework VIATRA. All techniques presented in this work
are illustrated by a running example from an eUniversity case study. 相似文献
7.
Preserving individual privacy when publishing data is a problem that is receiving increasing attention. Thanks to its simplicity the concept of k-anonymity, introduced by Samarati and Sweeney [1], established itself as one fundamental principle for privacy preserving data publishing. According to the k-anonymity principle, each release of data must be such that each individual is indistinguishable from at least k−1 other individuals. 相似文献
8.
Water Resources Management - This paper presents a comparison of different short-term water demand forecasting models. The comparison regards six models that differ in terms of: forecasting... 相似文献
9.
Mirco Wegener Luckman Muhmood Shouyi Sun Alex V. Deev 《American Institute of Chemical Engineers》2014,60(9):3350-3361
The experiments on the capillary breakup of slag jets at high temperatures are presented in this article. The impact of external excitations on the disintegration process was investigated in a furnace with optical access filmed at frame rates up to 10,000 fps. A synthetic calcia‐alumina slag was used to form jets at different temperatures (1570–1660°C) and jet velocities (0.6–1.4 ms?1). The impact of external vibration on the breakup was evident: for low jet velocities, the jet length decreased, the droplet size increased, satellite droplet formation was hindered, and a distinct “pumping mechanism” was observed. For jets with higher velocity, the jet length decreased by 30%, the droplet generation frequency increased from 20 to 250 droplets per second, the drop sizes were uniform, and satellite formation was also suppressed. In this case, the ideal case in which the volume of one wave instability forms one droplet was achieved. © 2014 American Institute of Chemical Engineers AIChE J, 60: 3350–3361, 2014 相似文献
10.
Yagmur Esemen Mariam Awan Rabeeia Parwez Arsalan Baig Shahinur Rahman Ilaria Masala Sonia Franchini Dimitrios Giakoumettis 《International journal of molecular sciences》2022,23(5)
Glioblastoma (GBM) is the most common and malignant tumour of the central nervous system. Recent appreciation of the heterogeneity amongst these tumours not only changed the WHO classification approach, but also created the need for developing novel and personalised therapies. This systematic review aims to highlight recent advancements in understanding the molecular pathogenesis of the GBM and discuss related novel treatment targets. A systematic search of the literature in the PubMed library was performed following the PRISMA guidelines for molecular pathogenesis and therapeutic advances. Original and meta-analyses studies from the last ten years were reviewed using pre-determined search terms. The results included articles relevant to GBM development focusing on the aberrancy in cell signaling pathways and intracellular events. Theragnostic targets and vaccination to treat GBM were also explored. The molecular pathophysiology of GBM is complex. Our systematic review suggests targeting therapy at the stemness, p53 mediated pathways and immune modulation. Exciting novel immune therapy involving dendritic cell vaccines, B-cell vaccines and viral vectors may be the future of treating GBM. 相似文献