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排序方式: 共有258条查询结果,搜索用时 0 毫秒
1.
T Akahoshi T Nagaoka R Namai N Sekiyama H Kondo 《Canadian Metallurgical Quarterly》1997,16(6):231-235
The effects of monosodium urate (MSU) crystals on apoptosis of cultured peripheral blood neutrophils were investigated. MSU crystals at low concentrations decreased the rate of spontaneous apoptosis of neutrophils in a dose- and time-dependent manner. The culture supernatant of MSU crystal stimulated neutrophils also promoted a delay in neutrophil apoptosis. MSU crystals at higher concentrations rapidly caused cell lysis. These findings indicated that MSU crystals are capable of amplifying the inflammatory responses of gouty arthritis by decreasing the rates of neutrophil apoptosis at lower concentrations and inducing cell lysis at higher concentrations. 相似文献
2.
Kawahito S. Ueda S. Ishida M. Nakamura T. Usui S. Nagaoka S. 《IEEE transactions on bio-medical engineering》1994,41(4):400-406
A CMOS integrated circuit for a noninvasive biological-signal telemetry system specified for use in medical and physiological studies of the influence of weightlessness in space is presented. The system can monitor multichannel (4 channels maximum) biological signals from multiple subjects (4 subjects maximum) in real time by using time multiplexing. A key technique so-called synchronized multiple-subject telemetry, to achieve multiple-subject telemetry has been proposed. This technique utilizes bidirectional optical transmissions with direct and scattered infrared lights between an observer and each of the subjects. An experimental CMOS IC to give a small light-weight low-power, and smart telemetry instrument for use on animals has been developed. This IC is for evaluating circuit blocks of the implantable monolithic telemetry instrument. The major circuit blocks include CMOS digital circuits for synchronization, subject selection and time multiplexing, analog circuits for pulse interval modulation, and other blocks such as a CMOS optical pulse receiver and an LED driver. A preliminary experimental multichannel telemetry from two subjects has been performed with the implemented IC chips, and the principal operation of the multiple-subject optical biotelemetry has been demonstrated 相似文献
3.
4.
S Suzuki M Saito N Suzuki H Kato N Nagaoka S Yoshitake Y Yui C Kawai 《Canadian Metallurgical Quarterly》1993,22(6):834-840
We examined the thrombolytic properties of a novel modified human tissue plasminogen activator (PA) (E6010), in which cysteine 84 is replaced by serine, and which has a prolonged biologic half-life (t1/2). We compared the thrombolytic efficacy of continuous intracoronary (i.c.) infusion of E6010 with that of recombinant human tissue PA (rt-PA) in a canine model with copper coil-induced 1-h-old coronary artery thrombi and also compared the relation between thrombolytic efficacy and plasma clearance represented by pharmacokinetic parameters of i.c.-infused E6010 and rt-PA. Sixty-minute E6010 and rt-PA i.c. infusions were compared. The thrombolytic effects of i.c.-infused E6010 and rt-PA, represented by time to reperfusion (TR), reperfusion rate at 60 min (RR), and reocclusion rates at 60 min after reperfusion (OR) were as follows. E6010: Dose 0.06, 0.15, 0.3 (mg/kg/h); TR 25 +/- 10, 15 +/- 10, 13 +/- 5 (min); RR 100, 100, 100 (%); and OR 0, 0, 17 (%), respectively. Recombinant t-PA: Dose 0.06, 0.15, 0.3 (mg/kg/h); TR 47 +/- 12, 18 +/- 17, 14 +/- 4 (min); RR 50, 75, 100 (%); and OR 100, 33, 33 (%), respectively. These findings indicate that E6010 has more potent thrombolytic activity than rt-PA.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
5.
Solid-liquid phase equilibria of the benzene + 2-methyl-2-propanol system have been investigated at temperatures from 278 to 323 K and pressures up to 300 MPa using a high-pressure optical vessel. The uncertainties of the measurements of temperature, pressure and composition are within ±0.1 K, ±0.5 MPa, and ±0.001 mole fraction, respectively. The freezing pressure at a constant composition increases monotonously with pressure. The eutectic point shifts to a higher temperature and benzene-rich composition with increasing pressure. In order to describe the pressure-temperature-composition relation of high-pressure solid-liquid phase equilibria, a new simple equation has been proposed as follows:
相似文献
6.
K. Nagaoka Y. Tanaka H. Kubota T. Makita 《International Journal of Thermophysics》1986,7(5):1023-1031
A new generalized correlation is presented for the low-pressure gaseous viscosity of fluorocarbon refrigerants. The following empirical equation is obtained based on the most reliable experimental data for 16 fluorocarbons: $$\eta \xi = \left( {0.5124T_r - 0.0517} \right)^{0.82} Z_c ^{ - 0.81}$$ where η is the viscosity in μPa·s and ξ is the viscosity parameter defined using the critical temperature T c in K, the critical pressure P c in MPa, and the molar mass M in g·mol?1 as follows: $$\xi = T_c ^{1/6} M^{ - 1/2} P_c ^{ - 2/3}$$ The applicable ranges are 0.6<T r<1.8 and 0.253<Z c<0.282. The availability of the correlating equation for both pure fluorocarbons and their mixtures has been investigated based on the experimental data of these authors and those in the literature. It is found that the present correlation is useful for the prediction of the viscosity of pure fluorocarbons and their binary mixtures at atmospheric pressure with mean deviations less than 1.6%. 相似文献
7.
Kimiyasu Sato Miyuki Kawai Yuji Hotta Takaaki Nagaoka Koji Watari 《Journal of the American Ceramic Society》2007,90(4):1319-1322
Because the pyrolysis of organic substances can result in the emission of harmful pollutant gases, a reduction in the use of organic binders is one aim of today's ceramics industry. A novel ceramic-forming process was developed that requires considerably less organic binder than conventional techniques. The process involves immobilizing reactive molecules on the surfaces of the particles, which on subsequent irradiation with microwaves, form bridges that bind the entire particle assembly together. The chemical forces involved produce strong bonds, resulting in a significant reduction in the amount of organic binder that is required to maintain the shape of the ceramic green body. This method will help to decrease emissions of harmful gases produced from pyrolysis of the binder. 相似文献
8.
Hajime Miyama Kouichi Tanaka Yoshio Nosaka Nobuyuki Fujii Hiroshi Tanzawa Shoji Nagaoka 《应用聚合物科学杂志》1988,36(4):925-933
Polyacrylonitrile-g-poly(N,N-dimethylaminoethyl methacrylate) was synthesized photochemically and quaternized. The positively charged membranes made from the quaternized graftcopolymer showed high ultrafiltration rate for water by adding poly(vinyl alcohol) to casting solution and washing it out after the casting. In buffered saline solution, the permeability of the membranes was very small at pH below isoelectric point of albumin but increased markedly at higher pH. On the other hand, the permeability for γ-globulin was very small and did not show any pH dependence. 相似文献
9.
Katsutoshi Nagaoka Kulathuiyer Seshan Kazuhiro Takanabe Ken-ichi Aika 《Catalysis Letters》2005,99(1-2):97-100
CH4/CO2 reforming over Pt/ZrO2, Pt/CeO2 and Pt/ZrO2 with CeO2 was investigated at 2 MPa. Pt/ZrO2, which shows stable activity under 0.1 MPa, and Pt/CeO2 showed gradual deactivation with time at the high pressure. The deactivation was suppressed drastically on Pt/ZrO2 with CeO2 prepared by different impregnation order (co-impregnation of Pt and CeO2 on ZrO2, and consecutive impregnation of Pt and CeO2 on ZrO2). The amount of coke deposition was found insignificant and similar among all the catalysts (including Pt/ZrO2 and Pt/CeO2). Catalytic activity after the reaction for 24 h was in agreement with Pt particle size after the reaction for same period, indicating that the difference of the catalytic stability is mainly dependent on the extent of Pt aggregation through catalyst preparation, H2 reduction, and the CH4/CO2 reforming. Pt aggregation and the amount of coke deposition were least pronounced on (Pt–Ce)/ZrO2 prepared by impregnation of CeO2 on Pt/ZrO2 and the catalyst showed highest stability. 相似文献
10.
Agglomeration control of hydroxyapatite nano-crystals grown in phase-separated microenvironments 总被引:1,自引:0,他引:1
Kimiyasu Sato Yuji Hotta Takaaki Nagaoka Masaki Yasuoka Koji Watari 《Journal of Materials Science》2006,41(17):5424-5428
Materials synthesis processes that require high temperatures consume large quantities of energy that generate an environmental burden. We attempted to synthesize hydroxyapatite (HAp) nano-crystals without firing or melting. “Water in oil” (W/O) emulsions were employed as microreactors for HAp formation. The surfactant-bounded water mediated HAp crystal nucleation, and HAp nano-crystallites were obtained. The obtained particles were aggregates composed of plate-like nano-crystals and monodisperse tiny crystals. Utilization of the W/O emulsions resulted in tunable nucleation frequency and the reactant provision, and yielded HAp nano-crystals with characteristic agglomeration properties. 相似文献
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