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排序方式: 共有270条查询结果,搜索用时 15 毫秒
1.
Navdeep Raghuwanshi Neha Arora Ritu Varshney Partha Roy Vikas Pruthi 《IET nanobiotechnology / IET》2017,11(7):827
This study for the first time reports on fresh water microalgae Chlorella minutissima aqueous extract (CmAe) which was utilized for the biogenic synthesis of silver nanoparticles and tested their antineoplastic potential against Liver Hepatocellular Carcinoma (HepG2) cell line. The characteristic colour change of the reaction mixture from greenish yellow to yellowish brown confirmed the synthesis of Chlorella minutissima silver nanoparticles (CmAgNPs). Microscopic analysis revealed CmAgNPs to be spherical‐shaped with particle size ranging from 10 to 30 nm. The carbohydrates and proteins distinctive peaks were observed in Fourier transform infrared spectroscopy (FTIR) spectra which suggested these biomolecules acted as reducing and capping agents. Further, the crystalline nature of CmAgNPs was confirmed by X‐ray diffraction (XRD) analysis. CmAgNPs showed maximum free radical scavenging proving it to be more potent antioxidant agent as compared to CmAe. The mortality rate of HepG2 cells treated with CmAgNPs was found to be 91.8 % at 120 μg/ml with IC50 value 12.42 ± 1.096 μg/ml after 48 h whereas no effect was observed on normal Human Embryonic Kidney (HEK 293) cells. Fluorescent images of the treated HepG2 cells revealed the formation of apoptotic bodies, condensed nuclei and cell shrinkage indicating their effectiveness against the cancer cells.Inspec keywords: silver, nanoparticles, nanomedicine, microorganisms, cellular biophysics, nanofabrication, scanning electron microscopy, transmission electron microscopy, atomic force microscopy, proteins, Fourier transform infrared spectra, molecular biophysics, X‐ray chemical analysis, X‐ray diffraction, kidney, cancer, biomedical materialsOther keywords: antineoplastic potential, antioxidant potential, phycofabricated silver nanoparticle, Chlorella minutissima, freshwater microalgae, aqueous extract, liver hepatocellular carcinoma cell line, CmAgNP synthesis, field emission scanning electron microscopy, high‐resolution transmission electron microscopy, atomic force microscopy, dynamic light scattering, carbohydrate, protein, Fourier transform infrared spectroscopy, biomolecule, energy‐dispersive X‐ray spectroscopy, elemental silver signal, CmAgNP crystalline, X‐ray diffraction analysis, antioxidant agent, HepG2 cell mortality rate, human embryonic kidney, HEK 293 cell, fluorescent image, apoptotic body formation, condensed nuclei, cell shrinkage, cancer cell, antineoplastic agent, Ag 相似文献
2.
In this present work, we explore the hot carrier fidelity of gate electrode workfunction engineered silicon nanowire (GEWE-SiNW) MOSFET at 300 K using DEVEDIT-3D device editor and ATLAS device simulation software. TCAD simulation shows reduction in the hot carrier reliability of a GEWE SiNW MOSFET in terms of electron temperature, electron velocity and Hot Electron gate current for reflecting its efficacy in high power CMOS applications. Further, a comparative investigation for different values of oxide thickness and high-k has been done to analyze the performance of GEWE-SiNW MOSFET in terms of electrical parameters such as conduction band, DIBL, electric field, electron temperature, electric velocity and gate current. It has been clearly shown that with oxide thickness 0.5 nm the hot-carrier reliability and device performance improves in comparison to oxide thickness 2.5 nm. In addition, with k = 21(HfO2) device performance in terms of hot-carrier reliability further enhanced due to increased capacitance and thus offer its effectiveness in sub-nm range analog applications. 相似文献
3.
4.
Abhinesh Kumar Prajapati Neha Sharma Rakesh Kumar Jena Preena Shrimal Parth Bagtharia Rajesh Kumar Kaushal 《分离科学与技术》2016,51(13):2276-2283
The electrochemical treatment (ECT) of textile wastewater was carried out in a 1.5 dm3 electrolyte batch reactor using iron electrodes. With the four plate configurations, a current density (CD) of 89.2 A/m2 and a pH value of 8.5 were found to be optimal, at which maximum reduction in chemical oxygen demand (COD) and colour achieved were 86% and 79%, respectively. Loss of 0.0666 kg/m3 iron electrode and 18.44 kWh/m3 power consumption was observed during ECT with a maximum COD reduction of 79%. The settling characteristics of electrochemically treated effluents as well as the characteristics of foam and residue were also analysed. 相似文献
5.
The impact of dietary fibers on dendritic cell responses in vitro is dependent on the differential effects of the fibers on intestinal epithelial cells 下载免费PDF全文
6.
Pradeep Bhartiya Neha Kaushik Linh N. Nguyen Sander Bekeschus Kai Masur Klaus-Dieter Weltmann Nagendra Kumar Kaushik Eun Ha Choi 《International journal of molecular sciences》2022,23(6)
Excess amounts of redox stress and failure to regulate homeostatic levels of reactive species are associated with several skin pathophysiologic conditions. Nonmalignant cells are assumed to cope better with higher reactive oxygen and nitrogen species (RONS) levels. However, the effect of periodic stress on this balance has not been investigated in fibroblasts in the field of plasma medicine. In this study, we aimed to investigate intrinsic changes with respect to cellular proliferation, cell cycle, and ability to neutralize the redox stress inside fibroblast cells following periodic redox stress in vitro. Soft jet plasma with air as feeding gas was used to generate plasma-activated medium (PAM) for inducing redox stress conditions. We assessed cellular viability, energetics, and cell cycle machinery under oxidative stress conditions at weeks 3, 6, 9, and 12. Fibroblasts retained their usual physiological properties until 6 weeks. Fibroblasts failed to overcome the redox stress induced by periodic PAM exposure after 6 weeks, indicating its threshold potential. Periodic stress above the threshold level led to alterations in fibroblast cellular processes. These include consistent increases in apoptosis, while RONS accumulation and cell cycle arrest were observed at the final stages. Currently, the use of NTP in clinical settings is limited due to a lack of knowledge about fibroblasts’ behavior in wound healing, scar formation, and other fibrotic disorders. Understanding fibroblasts’ physiology could help to utilize nonthermal plasma in redox-related skin diseases. Furthermore, these results provide new information about the threshold capacity of fibroblasts and an insight into the adaptation mechanism against periodic oxidative stress conditions in fibroblasts. 相似文献
7.
Whole grains and resistant starch rich,reduced‐calorie biscuit diet as a hypoglycaemic,hypolipidaemic and insulin stimulator in streptozotocin‐induced diabetic rats 下载免费PDF全文
Dipesh Aggarwal Latha Sabikhi Heena Lamba Neha Chaudhary Rajeev Kapila 《International Journal of Food Science & Technology》2017,52(1):118-126
A fibre‐enriched, reduced‐calorie biscuit [formulated biscuit (FB)] was evaluated for its antidiabetic and antilipidaemic potential in streptozotocin‐induced diabetes in Wistar rats against control biscuit (CB) having high calorie and low fibre content. Animals were allocated into five groups: a control group fed with synthetic diet, two diabetes‐induced groups (CBD and FBD) and two nondiabetic groups (CBND and FBND). CBD and CBND were fed with synthetic diet + CB while FBD and FBND were fed with synthetic diet + FB. After 6 weeks of feeding, the change in weight of nondiabetic group fed with FB (+16.20%) was nonsignificantly lower compared to control (+33.01%) and CB‐fed (+34.55%) group. Nonsignificant loss in body weight was observed among diabetic group fed with FB (?11.76%) or CB (?36.88%). Feeding of FB led to a significant decrease in fasting and postprandial blood glucose levels, total cholesterol, triglycerides, LDL‐C, VLDL‐C and atherosclerotic index and increase the HDL‐C. Histological examination showed that feeding of FB was able to partially recover the destroyed β‐cell in STZ‐induced diabetic rats. 相似文献
8.
B. S. Gera T. Raghavendra G. Singh V. K. Ojha Joginder Malik Neha Gera 《International journal of remote sensing》2013,34(17):4807-4817
A computer program has been developed to exploit the multimedia capabilities of a personal computer for a new design of sodar (sonic detection and ranging) data acquisition and control system with minimized hardware elements. Advantages include trouble-free, cost-effective and user-friendly sodar data acquisition using any standard computer. The new design overcomes limitations due to using an add-on data acquisition card with conventional computer-controlled sodar. The data can be processed to produce online display of the dynamics of prevailing atmospheric boundary layer thermal structures and inversion/mixing depth for environmental applications. 相似文献
9.
Arun Pandian Chandrasekaran Sang Hyeon Woo Neha Sarodaya Byung Ho Rhie Apoorvi Tyagi Soumyadip Das Bharathi Suresh Na Re Ko Seung Jun Oh Kye-Seong Kim Suresh Ramakrishna 《International journal of molecular sciences》2021,22(11)
Cell division cycle 25A (Cdc25A) is a dual-specificity phosphatase that is overexpressed in several cancer cells and promotes tumorigenesis. In normal cells, Cdc25A expression is regulated tightly, but the changes in expression patterns in cancer cells that lead to tumorigenesis are unknown. In this study, we showed that ubiquitin-specific protease 29 (USP29) stabilized Cdc25A protein expression in cancer cell lines by protecting it from ubiquitin-mediated proteasomal degradation. The presence of USP29 effectively blocked polyubiquitination of Cdc25A and extended its half-life. CRISPR-Cas9-mediated knockdown of USP29 in HeLa cells resulted in cell cycle arrest at the G0/G1 phase. We also showed that USP29 knockdown hampered Cdc25A-mediated cell proliferation, migration, and invasion of cancer cells in vitro. Moreover, NSG nude mice transplanted with USP29-depleted cells significantly reduced the size of the tumors, whereas the reconstitution of Cdc25A in USP29-depleted cells significantly increased the tumor size. Altogether, our results implied that USP29 promoted cell cycle progression and oncogenic transformation by regulating protein turnover of Cdc25A. 相似文献
10.
Vikram Awate Ratnesh Tiwari A. K. Shrivastava Neha Dubey Vikas Dubey 《Journal of Materials Science: Materials in Electronics》2018,29(6):4391-4401
This review includes research papers on different method of preparation of rare earth activated Sr2SiO4 phosphors and its luminescence studies. Here in Sr2SiO4 has attracted great interest due to its special structure features, excellent physical and chemical stability. Besides, it absorbs ultraviolet radiation and emits white light when activated by different rare earth ions. Different synthesis techniques were compared and it is found that sol–gel synthesis technique is best for preparation of rare earth activated Sr2SiO4 phosphors. Literature related to characterization techniques such as X-ray diffraction techniques, scanning electron microscopy, transmission electron microscopy and other studies are also compared. Photoluminescence studies for white light emitting diode of various rare earth phosphors are compared with Sr2SiO4 phosphor reported in this review. Also some luminescence techniques such as thermoluminescence glow curve analysis and some spectroscopic parameters are also compared. The review end with some important conclusion related to rare earth activated Sr2SiO4 phosphors with proper justifications. 相似文献