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Nisaraporn Suthiwangcharoen Tao Li Kai Li Preston Thompson Shaojin You Qian Wang 《Nano Research》2011,4(5):483-493
Poly(caprolactone-b-2-vinylpyridine) (PCL-P2VP) coated with folate-conjugated M13 (FA-M13) provides a nanosized delivery system which is capable
of encapsulating hydrophobic antitumor drugs such as doxorubicin (DOX). The DOX-loaded FA-M13-PCL-P2VP assemblies had an average
diameter of approximately 200 nm and their structure was characterized using transmission electron microscopy, scanning electron
microscopy, and dynamic light scattering. The particles were stable at physiological pH but could be degraded at a lower pH.
The release of DOX from the nanoassemblies under acidic conditions was shown to be significantly faster than that observed
at physiological pH. In addition, the DOX-loaded FA-M13-PCL-P2VP particles showed a distinctly greater cellular uptake and
cytotoxicity against folate-receptor-positive cancer cells than folate-receptor-negative cells, indicating that the receptor
facilitates folate uptake via receptor-mediated endocytosis. Furthermore, the DOX-loaded particles also had a significantly
higher tumor uptake and selectivity compared to free DOX. This study therefore offers a new way to fabricate nanosized drug
delivery vehicles. 相似文献
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