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排序方式: 共有3486条查询结果,搜索用时 31 毫秒
1.
Zaidatul Akmal Othman Zaida Zakaria Joseph Bagi Suleiman Victor Udo Nna Aminah Che Romli Wan Syaheedah Wan Ghazali Mahaneem Mohamed 《International journal of molecular sciences》2021,22(8)
Obesity and hyperlipidemia are major risk factors for developing vascular diseases. Bee bread (BB) has been reported to exhibit some biological actions, including anti-obesity and anti-hyperlipidemic. This study aims to investigate whether bee bread can ameliorate vascular inflammation and impaired vasorelaxation activity through eNOS/NO/cGMP pathway in obese rats. Forty male Sprague-Dawley rats were randomly divided into four groups (n = 10/group), namely: control (normal group), obese rats (OB group), obese rats treated with bee bread (0.5 g/kg/day, OB/BB group) and obese rats treated with orlistat (10 mg/kg/day, OB/OR group). The latter three groups were given a high-fat diet (HFD) for 6 weeks to induced obesity before being administered with their respective treatments for another 6 weeks. After 12 weeks of the total experimental period, rats in the OB group demonstrated significantly higher Lee obesity index, lipid profile (total cholesterol, triglyceride, low-density lipoprotein), aortic proinflammatory markers (tumor necrosis factor-α, nuclear factor-κβ), aortic structural damage and impairment in vasorelaxation response to acetylcholine (ACh). Bee bread significantly ameliorated the obesity-induced vascular damage manifested by improvements in the lipid profile, aortic inflammatory markers, and the impaired vasorelaxation activity by significantly enhancing nitric oxide release, promoting endothelial nitric oxide synthase (eNOS) and cyclic guanosine monophosphate (cGMP) immunoexpression. These findings suggest that the administration of bee bread ameliorates the impaired vasorelaxation response to ACh by improving eNOS/NO/cGMP-signaling pathway in obese rats, suggesting its vascular therapeutic role. 相似文献
3.
Sangmin Lee Biao Che Meiling Tai Wanzhao Li Shin-Hyun Kim 《Advanced functional materials》2021,31(42):2105477
Hydrogel shells that compartmentalize the water core from the aqueous surrounding provide molecular selectivity on size and charge in transmembrane transport. It is highly demanding to produce thin hydrogel shells to minimize diffusion length and maximize core volume. Here, internal osmosis in water-in-oil-in-water-in-oil (W/O/W/O) triple-emulsion droplets is used to produce thin hydrogel shells enclosing a large water core. The triple-emulsion droplets are prepared to have an ultrathin middle oil layer using a capillary microfluidic device. The innermost water droplet has a higher osmolarity than the outer water layer containing photopolymerizable hydrogel precursors, which pumps water from the outer layer to the core through the ultrathin oil layer by the osmosis. Therefore, the outer layer gets thinner and hydrogel precursors are enriched while the size of the triple-emulsion droplets remains unchanged. Through photopolymerization of precursors and phase transfer from oil to water, hydrogel shells enclosing water core are produced in the water environment; the oil layer is ruptured for molecular exchange through the shells. The thickness and composition of the hydrogel shells are precisely controllable by the osmotic conditions. The shells show a high permeation rate due to the thinness as well as controlled cut-off threshold of permeation for neutral and charged molecules. 相似文献
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Nur Lina Rashidah Mohd Rashid Abdullah Abdul Samat Abdul Azim Jais Mahendra Rao Somalu Andanastuti Muchtar Nurul Akidah Baharuddin Wan Nor Roslam Wan Isahak 《Ceramics International》2019,45(6):6605-6615
The performance of low-to-intermediate temperature (400–800?°C) solid oxide fuel cells (SOFCs) depends on the properties of electrolyte used. SOFC performance can be enhanced by replacing electrolyte materials from conventional oxide ion (O2-) conductors with proton (H+) conductors because H+ conductors have higher ionic conductivity and theoretical electrical efficiency than O2- conductors within the target temperature range. Electrolytes based on cerate and/or zirconate have been proposed as potential H+ conductors. Cerate-based electrolytes have the highest H+ conductivity, but they are chemically and thermally unstable during redox cycles, whereas zirconate-based electrolytes exhibit the opposite properties. Thus, tailoring the properties of cerate and/or zirconate electrolytes by doping with rare-earth metals has become a main concern for many researchers to further improve the ionic conductivity and stability of electrolytes. This article provides an overview on the properties of four types of cerate and/or zirconate electrolytes including cerate-based, zirconate-based, single-doped cerate–zirconate and hybrid-doped cerate–zirconate. The properties of the proton electrolytes such as ionic conductivity, chemical stability and sinterability are also systematically discussed. This review further provides a summary of the performance of SOFCs operated with cerate and/or zirconate proton conductors and the actual potential of these materials as alternative electrolytes for proton-conducting SOFC application. 相似文献
6.
Huseyin Avci Esra Akkulak Hazal Gergeroglu Hamed Ghorbanpoor Onur Uysal Ayla Eker Sariboyaci Bahar Demir Merve Nur Soykan Suat Pat Reza Mohammadigharehbagh Ceren Özel Ahmet Cabuk Fatma Doğan Güzel 《应用聚合物科学杂志》2020,137(26):49184
Among the thermoplastic elastomers that play important roles in the polymer industry due to their superior properties, styrene-based species and polyurethane block copolymers are of great interest. Poly(styrene-ethylene-butadiene-styrene) (SEBS) as a triblock copolymer seems to have the potential to meet many demands in different applications due to various industrial requirements where durability, biocompatibility, breaking elongation, and interfacial adhesion are important. In this study, the SEBS triblock copolymer was functionalized with natural (Satureja hortensis, SH) and synthetic (nanopowder, TiO2) agents to obtain composite nanofibers by electrospinning and electrospraying methods for use in biomedical and water filtration applications. The results were compared with thermoplastic polyurethane (TPU) composite nanofibers, which are commonly used in these fields. Here, functionalized SEBS nanofibers exhibited antibacterial effect while at the same time improving cell viability. In addition, because of successful water filtration by using the SEBS composite nanofibers, the material may have a good potential to be used comparably to TPU for the application. 相似文献
7.
渤海湾盆地石油地质储量和产量增长趋势的预测 总被引:3,自引:1,他引:2
渤海湾盆地的石油地质储量发现过程具有明显的渐进性、阶段性和长期性,石油产量的增长也具有一定的起伏性,用一个周期的单旋回哈伯特模型难以预测其发展趋势。通过分析渤海湾盆地的勘探开发历程,结合新一轮常规油气资源评价的结果,分别采用4个和3个哈伯特旋回拟合石油地质储量发现和产量增长曲线。预测结果显示,2005-2015年渤海湾盆地处于石油地质储量发现高峰期,2015年左右其石油产量达到高峰,之后处于下降趋势。实践证明,利用多旋回哈伯特模型对具有“多峰”特征的石油地质储量和产量的未来趋势进行预测是一种有效的方法。 相似文献
8.
Che Wun Chiou 《Electronics letters》2002,38(14):688-689
Based on Lee-Lu-Lee's array multipliers and the RESO method, a concurrent error detection scheme in array multipliers for GF(2m ) fields is presented and only one clock cycle is added. The fault tolerant capability in such array multipliers is also included and only two extra clock cycles are required 相似文献
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