The Effect of Alumina–Water Nanofluid on Natural Convection Heat Transfer Inside Vertical Circular Enclosures Heated from Above

Experimental investigation on natural convection heat transfer is carried out inside vertical circular enclosures filled with Al₂O₃–water nanofluid with different concentrations; 0.0%, 0.85% (0.21%), 1.98 (0.51%), and 2.95% (0.75%) by mass (volume). Two enclosures are used with 0.20 m inside diameter and with two different aspect ratios. The top surface of the enclosure is heated using a constant-heat-flux flexible foil heater while the bottom surface is subject to cooling using an ambient air stream. Various heat fluxes are used to generate heat transfer through the nanofluid. The average Nusselt number is obtained for each enclosure and correlated with the modified Rayleigh number using the concentration ratio as a parameter. A general correlation for the average Nusselt number with the modified Rayleigh number is obtained using the volume fraction and the aspect ratio as parameters to cover both enclosures. The results show that the Nusselt number for the alumina–water nanofluid is less than that of the base fluid. This means that using the alumina–water nanofluids adversely affects the heat transfer coefficient compared to using pure water. It is also found that the degree of deterioration depends on the concentration ratio as well as the aspect ratio of the enclosure.     

Nanofluid impingement jet heat transfer

Experimental investigation to study the heat transfer between a vertical round alumina-water nanofluid jet and a horizontal circular round surface is carried out. Different jet flow rates, jet nozzle diameters, various circular disk diameters and three nanoparticles concentrations (0, 6.6 and 10%, respectively) are used. The experimental results indicate that using nanofluid as a heat transfer carrier can enhance the heat transfer process. For the same Reynolds number, the experimental data show an increase in the Nusselt numbers as the nanoparticle concentration increases. Size of heating disk diameters shows reverse effect on heat transfer. It is also found that presenting the data in terms of Reynolds number at impingement jet diameter can take into account on both effects of jet heights and nozzle diameter. Presenting the data in terms of Peclet numbers, at fixed impingement nozzle diameter, makes the data less sensitive to the percentage change of the nanoparticle concentrations. Finally, general heat transfer correlation is obtained verses Peclet numbers using nanoparticle concentrations and the nozzle diameter ratio as parameters.     

Functionalized Fullerene for Inhibition of SARS-CoV-2 Variants

As virus outbreaks continue to pose a challenge, a nonspecific viral inhibitor can provide significant benefits, especially against respiratory viruses. Polyglycerol sulfates recently emerge as promising agents that mediate interactions between cells and viruses through electrostatics, leading to virus inhibition. Similarly, hydrophobic C₆₀ fullerene can prevent virus infection via interactions with hydrophobic cavities of surface proteins. Here, two strategies are combined to inhibit infection of SARS-CoV-2 variants in vitro. Effective inhibitory concentrations in the millimolar range highlight the significance of bare fullerene's hydrophobic moiety and electrostatic interactions of polysulfates with surface proteins of SARS-CoV-2. Furthermore, microscale thermophoresis measurements support that fullerene linear polyglycerol sulfates interact with the SARS-CoV-2 virus via its spike protein, and highlight importance of electrostatic interactions within it. All-atom molecular dynamics simulations reveal that the fullerene binding site is situated close to the receptor binding domain, within 4 nm of polyglycerol sulfate binding sites, feasibly allowing both portions of the material to interact simultaneously.