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排序方式: 共有56条查询结果,搜索用时 15 毫秒
1.
S Ohkawa A Yamadori K Maeda M Tabuchi Y Ohsumi E Mori T Yoshida Y Yoneda T Uehara 《Canadian Metallurgical Quarterly》1993,56(8):894-896
In right middle cerebral territory infarction a new sign, excessive closure of the right eye ipsilateral to the lesion and mild closure of the left eye on command, was noted. The excessive ipsilateral eye closure was not observed on spontaneous eye closure. 相似文献
2.
T Hatanaka K Fujita K Ohsumi R Nakagawa Y Fukuda Y Nihei Y Suga Y Akiyama T Tsuji 《Canadian Metallurgical Quarterly》1998,8(23):3371-3374
A series of B-ring modified combretastatin analogues were synthesized and their inhibitory activity against microtubule assembly, cytotoxic activity against Colon 26 adenocarcinoma cancer cell line were evaluated. Among these, pyridone derivative (19) showed strong antimitotic activity and cytotoxicity, along with excellent water-solubility. 相似文献
3.
二氧化碳地中隔离技术及其岩石力学问题 总被引:28,自引:5,他引:28
寻求经济又安全的强有力减排技术关系到日本政府能否履行在京都议定书中所作的承诺。二氧化碳是主要的温室气体,二氧化碳地中隔离是把从集中排放源分离得到的二氧化碳注入地下深处具有适当封闭条件的地层中隔离起来,即把二氧化碳归还原处——地球深部。介绍了二氧化碳地中隔离的概念及国际动态,并基于隔离容量、机理、安全性及成本分析,论述其可行性。 相似文献
4.
Identification of physical parameters of a flexible structure from noisy measurement data 总被引:1,自引:0,他引:1
We focus on an inverse problem for identifying physical parameters such as Young's modulus and air and structural damping coefficients in the mathematical model of cantilevered beams subject to random disturbance, using dynamic noisy data measured on its vibration taken in a nondestructive manner. First, we describe mathematical models of the cantilevered beam by an Euler-Bernoulli type partial differential equation including parameters to be identified and the measurement equation, taking vibration data including the observation noise. Second, the identification problem using random dynamic data is divided into an estimation problem obtaining the (modal) state estimate and a least-squares problem determining unknown parameters, and then the unknown parameters are determined recursively by using the pair of algorithms alternately. Finally, in order to verify the efficacy of the proposed identification algorithm, simulation studies and experiments are shown. 相似文献
5.
K Ohsumi T Hatanaka K Fujita R Nakagawa Y Fukuda Y Nihei Y Suga Y Morinaga Y Akiyama T Tsuji 《Canadian Metallurgical Quarterly》1998,8(22):3153-3158
A series of cis-restricted combretastatin analogues with 5-membered heterocycles were synthesized and their inhibitory activity against microtubule assembly and cytotoxic activity against the colon 26 adenocarcinoma cancer cell line were evaluated. Some of the heterocyclic analogues showed potent antitubulin activity and cytotoxicity. Compounds 16 and 35 showed marked tumor growth suppression in the colon 26 murine tumor model. 相似文献
6.
M Sugimoto M Miyazaki K Takemoto H Ohsumi H Tamura K Takeda 《Canadian Metallurgical Quarterly》1997,46(5):628-634
Endurance training has long been known to improve the individual's resistance to exercise-induced hypoglycemia. Traditionally attributed to a reduction in glucose uptake subsequent to enhanced fat oxidation, this issue has only recently been directly addressed. This paper briefly reviews the evidence for reduced glucose uptake versus enhanced glucose production in the improved hypoglycemic resistance following training. While whole body glucose removal and production may be reduced following training, this has only been demonstrated under exercising conditions in which glycemia demonstrates little deviation from rest. Under exercise conditions where untrained animals demonstrate substantial reductions in blood glucose, training enhanced hypoglycemic resistance has been shown to result entirely from enhanced glucose production via gluconeogenesis. Using the in situ perfused liver preparation, the authors have provided direct evidence for a training enhanced hepatic gluconeogenic capacity. The site of adaptation within the gluconeogenic pathway has now been constrained to below the level of the triose phosphates. Lack of evidence for suppressed skeletal muscle glucose uptake following training, a uniform observation for humans and rats, is also discussed. It is concluded that the improved hepatic gluconeogenic capacity of endurance trained individuals, at least in rats, is critical to their demonstrated resistance to exercise-induced hypoglycemia. 相似文献
7.
Autophagy is a bulk protein degradation process that is induced by starvation. The control mechanism for induction of autophagy is not well understood. We found that Tor, a phosphatidylinositol kinase homologue, is involved in the control of autophagy in the yeast, Saccharomyces cerevisiae. When rapamycin, an inhibitor of Tor function, is added, autophagy is induced even in cells growing in nutrient-rich medium. A temperature-sensitive tor mutant also leads to induction of autophagy at a nonpermissive temperature. These results indicate that Tor negatively regulates the induction of autophagy. Tor is the first molecule that is identified as a pivotal player in the starvation-signaling pathway of autophagy. Furthermore, we found that a high concentration of cAMP is inhibitory for induction of autophagy. APG gene products are involved in autophagy induced by starvation. Autophagy was not induced in apg mutants in the presence of rapamycin, indicating that the site of action of Tor is upstream of those of Apg proteins. In nutrient-rich medium, Apg proteins are involved also in the transport of aminopeptidase I from the cytosol to the vacuole. Tor may act to switch Apg function between autophagy and transport of aminopeptidase I. 相似文献
8.
Acidification inside vacuoles has been shown to play a key role in a number of physiologically important cellular events. We studied the role of vacuolar membrane H(+)-ATPase in the autophagic process of Saccharomyces cerevisiae. Mutants lacking VMA genes which encode their subunits of the vacuolar H(+)-ATPase accumulated autophagic bodies in vacuoles on starvation. vma mutants also had a defect in protein degradation induced by starvation. In vma mutants, the activities of vacuolar proteases were remarkably lower than those of the wild-type. Overexpression of vacuolar proteases did not overcome the defect in the disintegration of autophagic bodies in vma mutant, even the overexpressed proteinase A and proteinase B being substantially localized to the vacuolar compartment and undergoing proper proteolytic maturation. Our results showed that the acidification of vacuoles is not required for the formation and delivery of autophagosomes to vacuoles, but is essential for the disintegration of autophagic bodies. 相似文献
9.
S Higashi T Ohsumi K Ozumi K Kuroki Y Inokuchi M Terashita 《Canadian Metallurgical Quarterly》1998,17(3):186-194
Elimination of the data processing bottleneck in high-throughput sequencing will require both improved accuracy of data processing software and reliable measures of that accuracy. We have developed and implemented in our base-calling program phred the ability to estimate a probability of error for each base-call, as a function of certain parameters computed from the trace data. These error probabilities are shown here to be valid (correspond to actual error rates) and to have high power to discriminate correct base-calls from incorrect ones, for read data collected under several different chemistries and electrophoretic conditions. They play a critical role in our assembly program phrap and our finishing program consed. 相似文献
10.
The permeation characteristics for polymer aqueous solution and asymmetric structure of cellulose nitrate membranes, in particular the finger-like cavity in the back sponge layer of these membranes, were investigated by changing the preparation conditions of the membranes— the casting solvent, evaporation period, and gelation medium. The formation of the finger-like cavity was dependent on absorption of a water molecule into the casting mixture from the atmosphere during the solvent evaporation process and the exchange velocity between the casting solvent and the gelation medium. The mechanism and conditions for the formation of a finger-like cavity in cellulose nitrate membranes were discussed. 相似文献