The Role of microRNAs in Development of Colitis-Associated Colorectal Cancer

Colorectal cancer (CRC) is the third most deadly cancer worldwide, and inflammatory bowel disease (IBD) is one of the critical factors in CRC carcinogenesis. IBD is responsible for an unphysiological and sustained chronic inflammation environment favoring the transformation. MicroRNAs (miRNAs) belong to a class of highly conserved short single-stranded segments (18–25 nucleotides) non-coding RNA and have been extensively discussed in both CRC and IBD. However, the role of miRNAs in the development of colitis-associated CRC (CAC) is less clear. The aim of this review is to summarize the major upregulated (miR-18a, miR-19a, miR-21, miR-31, miR-155 and miR-214) and downregulated (miR-124, miR-193a-3p and miR-139-5p) miRNAs in CAC, and their roles in genes’ expression modulation in chronic colonic-inflammation-induced carcinogenesis, including programmed cell-death pathways. These miRNAs dysregulation could be applied for early CAC diagnosis, to predict therapy efficacy and for precision treatment.     

动载荷下应力强度因子的边界元计算

用Ｎａｒｄｉｎｉ－Ｂｒｅｂｂｉａ边界元法计算了动载荷下的应力强度因子，与解析解及有限元解相比较，效果较好。最后对计算结果进行了分析讨论。     

Contractor as Trust Initiator in Construction Partnering—Prisoner’s Dilemma Perspective

Partnering has been advocated for use in construction as a project-delivery approach to curb dispute and enable a cooperative contracting environment. Successful construction partnering is perceived to derive benefits to both developers and contractors. In view of significant implications to successful project delivery, there has been a surge of research and studies on construction partnering. These studies typically focus on the partnering process as well as the identification of critical success factors. Among the various success factors that underpin partnering success, establishing trust among partners is considered the most important. Moreover, skeptics have been swift to point out that establishing trust in construction is daunting. A better understanding of the role of trust and its manifestation in partnering efforts is therefore of both academic and practical value. In this study, motivating trust in construction partnering is described within the classic framework of “the prisoner’s dilemma,” which suggests the trust cycle can be kick-started if construction partners put cooperation before competition and self-interest. This paper reports a study that is designed to suggest a suitable candidate for the trust initiator. As such, the critical trust factors for two groups of construction partners in Hong Kong—developers/consultants and contractors—are first identified. It is found that “performance” and “permeability” of partners are the two most critical trust factors. “Performance” describes the partner’s competence and problem-solving ability as perceived by their counterpart. “Permeability” reflects the partner’s openness in sharing information. The result of a multiple-regression analysis further suggests that the contractor is in a position to initiate trust through competent performance and maintaining effective communication with the client. In this manner, the trust cycle can expand with reciprocal trustworthiness from the client.     

Effects of pineapple pomace fibre on physicochemical properties of composite flour and dough,and consumer acceptance of fibre‐enriched wheat bread

Pineapple pomace fibre (PF, containing 70.2% total dietary fibre) can be added to increase dietary fibre of wheat bread. This study was performed to evaluate effects of PF added at 0, 5 or 10% (wheat flour‐basis) on physicochemical properties of the composite flour (wheat flour as the control, CPF‐5 and CPF‐10, respectively) and its dough, to evaluate consumer acceptance of CPF breads and to identify factors affecting willingness to purchase of CPF breads. Incorporating PF affected rheological and pasting properties of CPF. Water‐ and oil‐holding capacity of CPF increased (P < 0.05) as PF levels increased. Bread made with CPF‐5 was more acceptable than that with CPF‐10; however, it was not significantly different from the control, having similar specific volume and texture, but having about three times higher total dietary fibre than the control (4.4% vs. 1.5%). Product label and health benefit information potentially affected consumers' willingness to purchase of fibre‐enriched bread.     

集中式及分散式车门控制模块方案

随着汽车电子设备的不断增多,汽车系统设计复杂度也在不断提升。为应对日趋复杂的汽车车门控制设计,本文介绍了安森美半导体提供的器件选型及系统解决方案。     

A web‐based performance assessment system for environmental protection: WePass

In response to the increasing public concern over the effects of construction waste on the environment, a performance assessment system has been designed to provide an instant, online assessment of how well a construction site performs environmentally, e.g. measuring the level of pollution generated from a construction site. Through the use of both Internet and database technologies, it is possible to collect and present data that are essential for environmental management online. To achieve this, a set of environmental performance parameters was derived through a postal questionnaire survey and interviews with experts in the field. A conceptual framework was developed, of which the key components were: template, knowledge base, output data and benchmark group. In combination, these factors provide a system that enables speedy assessment and effective management of environmental performance on construction sites, hence prompt decisions can be made and corrective actions can be taken before potential hazards turn into real disasters.     

Delay-dependent H_2/H_∞ Control for Vehicle Magneto-rheological Semi-active Suspension

The exist researches of the magneto-rheological semi-active suspension(MSAS) control mainly focus on the design of control laws,which aim at obtaining an optimal control strategy to improve the ride comfort and handling stability.In the controller design,the stability of the MSAS system cannot be confirmed owing to the control input time delay considered little.In this paper,a quarter vehicle MSAS model with time-delay is built.Therefore,through formulating the sprung mass acceleration suitably as the optimization object,suspension deflection and tyre dynamic load and coulomb damping force as the constraint objects,with considering the control input time-delay,a delay-dependent state feedback H2/H∞ controller is designed.According to Lyapunov-Krasovskii functional theory,the sufficient conditions for asymptotic stability and the existence of delay-dependent H2/H∞ controller are obtained,and the controller design is transformed into the minimization problem for linear function through linear matrix inequality(LMI).Random road excitation simulations and experiments are carried out.The simulation and experiment results show that the design can preserve the closed-loop stability and achieve the performances for MSAS system in spite of the existence of the control input time-delay.The present study can provide an important basis and method for research on time-delay problem in MSAS and other chassis subsystems..     

台阶深孔微差爆破在港口工程中的应用

台阶深孔微差爆破是一种大规模、快速的土石方施工方法。本文就连云港庙岭开山填海建港工程中，台阶深孔微差爆破技术的应用情况、多年来的施工经验体会作了介绍，并对一些爆破理论进行了讨论。另外，就爆破工作在管理上存在的问题和改善管理后取得的效果作了分析。     

Chemiluminescent and Antioxidant Micelles as Theranostic Agents for Hydrogen Peroxide Associated‐Inflammatory Diseases

Hydrogen peroxide (H₂O₂) is one of essential oxygen metabolites in living organisms, but is generated in large amounts during inflammatory responses. Therefore, H₂O₂ has great potential as diagnostic and therapeutic markers of several inflammatory and life‐threatening diseases. Here, chemiluminescent and antioxidant micelles are reported as novel theranostic agents for H₂O₂‐associated inflammatory diseases. The chemiluminescent micelles composed of amphiphilic block copolymer Pluronic F‐127, hydroxybenzyl alcohol‐incorporated copolyoxalate (HPOX) and fluorescent dyes perform peroxalate chemiluminescence reactions to detect H₂O₂ as low as 100 nM and image H₂O₂ generated in inflamed mouse ankles. The micelles encapsulating HPOX reduce the generation of reactive oxygen species in lipopolysaccharide (LPS)‐activated macrophages by scavenging overproduced H₂O₂ and releasing antioxidant hydroxybenzyl alcohol (HBA). They also exert inhibitory effects on H₂O₂‐induced apoptosis. HPOX‐based chemiluminescent and antioxidant micelles have great potential as a theranostic agent for H₂O₂‐associated inflammatory diseases.     

氩离子激光泵浦的掺钛宝石激光器研究

本文报导用氩离子激光连续泵浦的掺钛宝石(Ti~(3+),Al_2O_3)可调谐固体激光器的实验结果。泵浦光为全谱线,基模,激光器采用消象散的折叠谐振腔结构,获得基模激光输出功率0.67W,效率大于10.8％,可调谐范围为735nm～900nm。