Acromioclavicular joint cyst and rotator cuff tear

The role of a depressor factor, atrial natriuretic peptide, in the development of arterial hypertension in adolescents with pubertal hypothalamic syndrome was studied in 52 patients and 13 healthy males aged 13-24 years. The duration of disease was 2-11 years. Radioimmunological methods were used to measure plasma atrial natriuretic peptide, plasma renin activity, and serum aldosterone. Patients with borderline arterial hypertension were found to have a significant reduction in their atrial natriuretic peptide levels, and this correlated directly with the renin-aldosterone system, demonstrating insufficiency of the depressor system in patients with pubertal hypothalamic syndrome and the involvement of atrial natriuretic peptide in the development of arterial hypertension, along with disturbances in the functional relationship between atrial natriuretic peptide and the renin-aldosterone system.     

Confocal Blood Flow Videomicroscopy of Thrombus Formation over Human Arteries and Local Targeting of P2X7

Atherothrombosis exposes vascular components to blood. Currently, new antithrombotic therapies are emerging. Herein we investigated thrombogenesis of human arteries with/without atherosclerosis, and the interaction of coagulation and vascular components, we and explored the anti-thrombogenic efficacy of blockade of the P2X purinoceptor 7 (P2X7). A confocal blood flow videomicroscopy system was performed on cryosections of internal mammary artery (IMA) or carotid plaque (CPL) determining/localizing platelets and fibrin. Blood from healthy donors elicited thrombi over arterial layers. Confocal microscopy associated thrombus with tissue presence of collagen type I, laminin, fibrin(ogen) and tissue factor (TF). The addition of antibodies blocking TF (aTF) or factor XI (aFXI) to blood significantly reduced fibrin deposition, variable platelet aggregation and aTF + aFXI almost abolished thrombus formation, showing synergy between coagulation pathways. A scarce effect of aTF over sub-endothelial regions, more abundant in tissue TF and bundles of laminin and collagen type I than deep intima, may suggest tissue thrombogenicity as molecular structure-related. Consistently with TF-related vascular function and expression of P2X7, the sections from CPL but not IMA tissue cultures pre-treated with the P2X7 antagonist A740003 demonstrated poor thrombogenesis in flow experiments. These data hint to local targeting studies on P2X7 modulation for atherothrombosis prevention/therapy.     

Liquid-phase hot-pressing and WC-particle reinforcement of SiC-Si composites

The sintering behaviour of SiC-Si and SiC-Si-WC composites hot-pressed via silicon liquid phase has been studied. The results show that the increase of silicon makes the sintered materials densify at lower temperature and the grain growth is restricted due to the effect of the liquid. The strength of SiC-25 vol.% Si samples is higher than the strength obtained for SiC-5 vol.% Si with the same hot-pressing conditions. The addition of WC particles improves relative densities and strengths of SiC-Si ceramics.     

Real-Time Global Illumination for VR Applications

Real-time global illumination in VR systems enhances scene realism by incorporating soft shadows, reflections of objects in the scene, and color bleeding. The Virtual Light Field (VLF) method enables real-time global illumination rendering in VR. The VLF has been integrated with the Extreme VR system for real-time GPU-based rendering in a Cave Automatic Virtual Environment.     

Model-based cold-start speed control scheme for spark ignition engines

This paper presents a model-based control scheme to the cold-start speed control in spark ignition (SI) engines. The multi-variable control algorithm is developed with the purpose of improving the transient performance of the starting engine speed: the control inputs are the fuel injection, the throttle and the spark advance (SA), while the engine speed and the air mass flow rate are the measured signals. The fuel injection is performed with a dual sampling rate system: the cycle-based fuel injection command is individually adjusted for each cylinder by using a TDC (top dead center)-based air charge estimation. The desired performance for speed regulation is achieved by using a coordinated control of SA and throttle operation. The speed error convergence of the closed loop system is proved for simplified, second-order model with a time-delay, and the robustness with respect to parameter uncertainties is investigated. The performance and the robustness with respect to modeling uncertainties of the proposed control scheme are tested using an industrial engine simulator with six cylinders.     

An adaptive learning regulator for uncertain minimum phase systems with undermodeled unknown exosystems

The design of an adaptive learning regulator is addressed for uncertain minimum phase linear systems (with known bounds, known upper bound on system order, known relative degree, known high frequency gain sign) and for unknown exosystems (with unknown order, uncertain frequencies). On the basis of a known bound on system uncertainties and a known bound on the modeled exosystem frequencies, a new adaptive output error feedback control algorithm is proposed which guarantees exponential convergence of both the output and the control input errors into residual bounds which decrease as the exosystem modeling error decreases. Exponential convergence of both errors to zero is obtained when the regulator exactly models all exosystem excited frequencies, while asymptotic convergence of both errors to zero is achieved when the actual exosystem is overmodeled by the regulator. The new algorithm generalizes existing learning controllers since, in the case of periodic references and/or disturbances, the knowledge of the period is not required.     

Glass-fibre-reinforced composites with enhanced mechanical and electrical properties - Benefits and limitations of a nanoparticle modified matrix

Nanoparticles and especially carbon nanotubes (CNTs) provide a high potential for the modification of polymers. They are very effective fillers regarding mechanical properties, especially toughness. Furthermore, they allow the implication of functional properties, which are connected to their electrical conductivity, into polymeric matrices. In the present paper, different nanoparticles, as fumed silica and carbon black, were used to optimise the epoxy matrix system of a glass-fibre-reinforced composite. Their nanometre-size enables their application as particle-reinforcement in FRPs produced by the resin-transfer-moulding method (RTM), without being filtered by the glass-fibre bundles. Additionally, an electrical field was applied during curing, in order to enhance orientation of the nanofillers in z-direction. The interlaminar shear strengths of the nanoparticle modified composites were significantly improved (+16%) by adding only 0.3 wt.% of CNTs. The interlaminar toughness G_Ic and G_IIc was not affected in a comparable manner. The laminates containing carbon nanotubes exhibited a relatively high electrical conductivity at very low filler contents, which allows the implication of functional properties, such as stress-strain monitoring and damage detection.     

Photorefractive gratings in DR1-doped hybrid sol–gel films

Photorefractive gratings have been obtained with 632.8 nm writing beams in organic–inorganic SiO₂-based films. The hybrid glass is prepared by a sol–gel technique, starting from organic Si precursors, and contains Disperse Red 1 (DR1), carbazole units and 2,4,7-trinitro-9-fluorenone (TNF). The photorefractive gain, which has been found unexpectedly even without poling field, has been determined through an asymmetric energy exchange by two-beam coupling measurements. The effects of the polarization of the writing beams and of a circularly polarized photoisomerizing radiation during the erasure of the grating have been interpreted in terms of an orientational contribution to the grating formation.     

The Columbia University sub-micron charged particle beam

A lens system consisting of two electrostatic quadrupole triplets has been designed and constructed at the Radiological Research Accelerator Facility (RARAF) of Columbia University. The lens system has been used to focus 6 MeV ⁴He ions to a beam spot in air with a diameter of 0.8 μm. The quadrupole electrodes can withstand voltages high enough to focus ⁴He ions up to 10 MeV and protons up to 5 MeV. The quadrupole triplet design is novel in that alignment is made through precise construction and the relative strengths of the quadrupoles are accomplished by the lengths of the elements, so that the magnitudes of the voltages required for focusing are nearly identical. The insulating sections between electrodes have had ion implantation to improve the voltage stability of the lens. The lens design employs Russian symmetry for the quadrupole elements.