Glycosylation in Indolent,Significant and Aggressive Prostate Cancer by Automated High-Throughput N-Glycan Profiling

The diagnosis and treatment of prostate cancer (PCa) is a major health-care concern worldwide. This cancer can manifest itself in many distinct forms and the transition from clinically indolent PCa to the more invasive aggressive form remains poorly understood. It is now universally accepted that glycan expression patterns change with the cellular modifications that accompany the onset of tumorigenesis. The aim of this study was to investigate if differential glycosylation patterns could distinguish between indolent, significant, and aggressive PCa. Whole serum N-glycan profiling was carried out on 117 prostate cancer patients’ serum using our automated, high-throughput analysis platform for glycan-profiling which utilizes ultra-performance liquid chromatography (UPLC) to obtain high resolution separation of N-linked glycans released from the serum glycoproteins. We observed increases in hybrid, oligomannose, and biantennary digalactosylated monosialylated glycans (M5A1G1S1, M8, and A2G2S1), bisecting glycans (A2B, A2(6)BG1) and monoantennary glycans (A1), and decreases in triantennary trigalactosylated trisialylated glycans with and without core fucose (A3G3S3 and FA3G3S3) with PCa progression from indolent through significant and aggressive disease. These changes give us an insight into the disease pathogenesis and identify potential biomarkers for monitoring the PCa progression, however these need further confirmation studies.     

Asymptotic performance of single parity-check product codes

This article investigates the asymptotic performance of single parity-check (SPC) product codes (PCs) from a decoding point of view. Specifically, the probability of bit error is bounded before and after the decoding of each dimension, similar to the analysis of "iterated codes" by Elias (1954). It is shown that the asymptotic probability of bit error can be driven to zero as the number of dimensions, and hence the block length, increases at signal-to-noise ratios (SNRs) within 2 dB of capacity over the additive white Gaussian noise (AWGN) channel.     

Projection of the sexually dimorphic area of the gerbil hypothalamus to the retrorubral field is essential for male sexual behavior: Role of A8 and other cells.

To determine if the sexually dimorphic area (SDA) of the gerbil hypothalamus affects male sexual behavior through its projections to the retrorubral field (RRF) or ventrolateral periaqueductal gray (PAGvl), these pathways were lesioned asymmetrically. Unilateral radio frequency lesions of the lateral SDA (LSDA), the major source of the pathways, impaired mating when combined with contralateral RRF, but not PAGvl, lesions. N-methyl-{d}-aspartate (NMDA) lesions of the medial SDA, LSDA, and the area between them (the total pathway source) eliminated mating when combined with contralateral, but not ipsilateral, NMDA lesions of the RRF. To determine if A8 cells contributed to these effects, males received NMDA in the SDA and NMDA or 6-hydroxydopamine in the contralateral RRF. When combined with large SDA lesions, A8 lesions impaired but did not eliminate mating. Thus the SDA–RRF pathway, but not an SDA-A8 pathway, is essential for sexual behavior in male gerbils. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Isotherm analyses for single component and multi-component metal sorption onto lignite

The adsorption of the three metal ions, copper, cadmium and zinc in single component and multi-component mixtures in aqueous solutions by lignite is reported. A comparison is made between the single component saturation uptake and the multi-component uptakes. The isotherms indicate a competitive uptake with copper being preferentially absorbed by the lignite in multi-component solutions. The isotherms are plotted to obtain the Langmuir constants, the Freundlich constants and the Redlich–Peterson constants. Lignite is shown to possess an affinity for the metal ions which make its use as an adsorbent a possible alternative to the use of more expensive activated carbons.     

Adaptive output-feedback stabilization of non-local hyperbolic PDEs

We address the problem of adaptive output-feedback stabilization of general first-order hyperbolic partial integro-differential equations (PIDE). Such systems are also referred to as PDEs with non-local (in space) terms. We apply control at one boundary, take measurements on the other boundary, and allow the system’s functional coefficients to be unknown. To deal with the absence of both full-state measurement and parameter knowledge, we introduce a pre-transformation (which happens to be based on backstepping) of the system into an observer canonical form. In that form, the problem of adaptive observer design becomes tractable. Both the parameter estimator and the control law employ only the input and output signals (and their histories over one unit of time). Prior to presenting the adaptive design, we present the non-adaptive/baseline controller, which is novel in its own right and facilitates the understanding of the more complex, adaptive system. The parameter estimator is of the gradient type, based on a parametric model in the form of an integral equation relating delayed values of the input and output. For the closed-loop system we establish boundedness of all signals, pointwise in space and time, and convergence of the PDE state to zero pointwise in space. We illustrate our result with a simulation.     

A Perceptual Comparison of Empirical and Predictive Region-of-Interest Video

When viewing multimedia presentations, a user only attends to a relatively small part of the video display at any one point in time. By shifting allocation of bandwidth from peripheral areas to those locations where a user's gaze is more likely to rest, attentive displays can be produced. Attentive displays aim to reduce resource requirements while minimizing negative user perception-understood in this paper as not only a user's ability to assimilate and understand information but also his/her subjective satisfaction with the video content. This paper introduces and discusses a perceptual comparison between two region-of-interest display (RoID) adaptation techniques. A RoID is an attentive display where bandwidth has been preallocated around measured or highly probable areas of user gaze. In this paper, video content was manipulated using two sources of data: empirical measured data (captured using eye-tracking technology) and predictive data (calculated from the physical characteristics of the video data). Results show that display adaptation causes significant variation in users' understanding of specific multimedia content. Interestingly, RoID adaptation and the type of video being presented both affect user perception of video quality. Moreover, the use of frame rates less than 15 frames per second, for any video adaptation technique, caused a significant reduction in user perceived quality, suggesting that although users are aware of video quality reduction, it does impact level of information assimilation and understanding. Results also highlight that user level of enjoyment is significantly affected by the type of video yet is not as affected by the quality or type of video adaptation-an interesting implication in the field of entertainment.     

移动无线传感器网络系统在n-Rayleigh信道下的性能分析

在n￣Rayleigh信道下,研究了使用选择合并( SC)接收的移动无线传感器网络系统的平均符号误码率( ASEP )和信道容量。基于矩生成函数( MGF)方法,推导了系统采用相干检测的相移键控调制( PSK),正交幅度调制( QAM),脉冲幅度调制(PAM)等数字调制方式的ASEP的精确表达式。同时,也得到了系统信道容量的精确表达式。然后对不同条件下的ASEP和信道容量性能做了数值仿真,理论分析结果与仿真结果相吻合,验证了理论分析结果的正确性。仿真结果表明：随着分集支路数的增加,系统的ASEP和信道容量性能得到了很好的改善,当使用QPSK调制,信噪比为16 dB时,分集支路数L＝1,系统的误码率是6×10－2,信道容量是4(bit/s)/Hz;分集支路数L＝2,系统的误码率是1×10－2,信道容量是5.1(bit/s)/Hz;分集支路数L＝3,系统的误码率是2×10－3,信道容量是5.8(bit/s)/Hz。     

Samuel Bourne of Nottingham

Abstract

Samuel Bourne was one of the great pioneers of travel photography, and the photographs which he took in India during the 1860s have become familiar to a wide audience through their inclusion in exhibitions, their use as book illustrations and also through television coverage. Although acknowledging the merit of that aspect of his work, this paper discusses the hitherto comparatively little-known role which he played in the arena of photography during the period immediately before he went to India, and also his activities in the latter part of the 19th and early 20th centuries.     

Improved thin film stability of differently formulated,printed, and crosslinked polymer layers against successive solvent printing

Interface control remains a top challenge of solution-processed organic light emitting diodes (OLED) stacks since the device performance heavily relies on it. Film stability of an inkjet deposited and crosslinked layer against subsequent exposure to a suitable inkjet printed solvent has been investigated. Impact of processing solvent (solvent used to prepare the polymer layer) on solution-cast thin film properties has already been shown for polymer films. To our knowledge, this study is the first one analyzing thin films stability against solvent exposure using technology relevant materials processed via inkjet printing (IJP). The outcome of this research showed that the stability of the crosslinked films is affected by the solvent used for ink formulation. These findings are of great interest for multilayered semiconductors devices, such as OLEDs, field-effect transistors and dye-sensitized solar cells. Differential scanning calorimetry (DSC) was used to quantify the efficiency of the polymer crosslinking reaction in pure powder and in thin films, as processed from different solvents. Crosslinking efficiency measured by DSC correlated well with the deformation induced by the solvent and observed on layer surfaces. The interaction in solution between polymer and solvent has also been evaluated to explain its impact on thin film stability against successive solvent printing. © 2020 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020 , 137, 48895.