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排序方式: 共有128条查询结果,搜索用时 9 毫秒
1.
Ming-Yen Hsiao Ya-Wen Wu Wen-Shiang Chen Yu-Ling Lin Po-Ling Kuo Chueh-Hung Wu 《International journal of molecular sciences》2021,22(7)
Entrapment neuropathy (EN) is a prevalent and debilitative condition caused by a complex pathogenesis that involves a chronic compression–edema–ischemia cascade and perineural adhesion that results in excessive shear stress during motion. Despite decades of research, an easily accessible and surgery-free animal model mimicking the mixed etiology is currently lacking, thus limiting our understanding of the disease and the development of effective therapies. In this proof-of-concept study, we used ultrasound-guided perineural injection of a methoxy poly(ethylene glycol)-b-Poly(lactide-co-glycoilide) carboxylic acid (mPEG-PLGA-BOX) hydrogel near the rat’s sciatic nerve to induce EN, as confirmed sonographically, electrophysiologically, and histologically. The nerve that was injected with hydrogel appeared unevenly contoured and swollen proximally with slowed nerve conduction velocities across the injected segments, thus showing the compressive features of EN. Histology showed perineural cellular infiltration, deposition of irregular collagen fibers, and a possible early demyelination process, thus indicating the existence of adhesions. The novel method provides a surgery-free and cost-effective way to establish a small-animal model of EN that has mixed compression and adhesion features, thus facilitating the additional elucidation of the pathophysiology of EN and the search for promising treatments. 相似文献
2.
Poly(vinyl pyrrolidone‐co‐isobutyl styryl polyhedral oligomeric silsesquioxane)s (PVP–POSS) were synthesized by one‐step polymerization and characterized using FTIR, high‐resolution 1H‐NMR, solid‐state 13C‐NMR, 29Si‐NMR, GPC, and DSC. The POSS content can be controlled by varying the POSS feed ratio. The Tg of the PVP–POSS hybrid is influenced by three main factors: (1) a diluent role of the POSS in reducing the self‐association of the PVP; (2) a strong interaction between the POSS siloxane and the PVP carbonyl, and (3) physical aggregation of nanosized POSS. At a relatively low POSS content, the role as diluent dominates, resulting in a decrease in Tg. At a relatively high POSS content, the last two factors dominate and result in Tg increase of the PVP–POSS hybrid. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 91: 2208–2215, 2004 相似文献
3.
Tuna are highly priced fishes that are often used in processed products. For effective fishery management and protection of consumers’ rights, it is important to develop a molecular method to identify the species of the tuna products. In this study we have developed a molecular method based on real-time polymerase chain reaction (real-time PCR) technology for the rapid identification of four tuna species. Four species-specific TaqMan probes were designed to identify bigeye tuna (Thunnus obesus), Pacific bluefin tuna (Thunnus orientalis), southern bluefin tuna (Thunnus maccoyii), and yellowfin tuna (Thunnus albacares). A SYBR green system was also designed to enhance the authentication of T. obesus. Both systems can distinguish target species from others in an efficient and high-throughput manner and can be applied to species identification of tuna products. 相似文献
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5.
T. J. Lardner J. E. Ritter M. L. Shiao M. R. Lin 《International Journal of Fracture》1990,44(2):133-143
The purpose of this research was to examine problems associated with the propagation of cracks near a free surface and near the interface of a glass/epoxy bonded system. Crack propagation was induced by placing Knoop indentations in the glass at various sites adjacent to and remote from the surface or interface. These experimental studies were supplemented by finite element stress analysis. Experiments show that for an indent parallel to the surface or interface, the initial direction of crack propagation from the indent is always toward the surface or interface and then as the crack approaches the surface or interface, the crack path deviates away from the surface. Results of finite element analysis show that the initial direction of crack propagation is in the direction normal to the maximum principal stress at the crack tip.
Résumé Le but de cette recherche a été d'examiner les problèmes associés à la propagation des fissures près d'une surface libre et au voisinage de l'interface d'un assemblage verre-époxy collé. La propagation d'une fissure était blovoquée par des empreites Knoop en divers endroits adjacents ou éloignés de la surface ou de l'interface. Ces tudes expérimentales ont été complétées par une analyse des contraintes par éléments finis. Les essais ont montré The pour une empreinte parallèle à la surface ou à l'interface, la direction initiale de la propagation d'une fissure depuis cette empreinte est toujours orientée vers la surface libre ou vers l'interface. Ensuite, au fur et à mesure que fissure se rapproche de la surface libre ou de l'interface, son chemin s'en détourne. Les résultats de l'analyse par Sléments finis montrent que la direction initiale de propagation de la fissure est normale à la tension principale maximum à l'extrémité de la fissure.相似文献
6.
Shui Jinn Wang Hao Yi Tsai S. C. Sun M. H. Shiao 《Journal of Electronic Materials》2001,30(8):917-924
Characterization of sputtered tantalum carbon nitride (Ta-C-N) film in Cu/barrier/Si system was reported for the first time. With a 50∶50 wt.% TaC target and an optimum N2/Ar flow rate (in sccm) ratio of 2/24, a 600 Å-thick sputtered Ta-C-N layer was shown metallurgically stable up to 650°C annealing for 30 min, which is about 100°C higher as compared to the case without nitrogen doping. Cu diffusion through the local defects or grain boundaries of the Ta-C-N barrier layer into Si substrate is the dominant factor responsible for the failure of the Ta-C-N barrier layer after high temperature annealing. 相似文献
7.
Shiao‐Wei Kuo Chien‐Chou Shih Jye‐Shiou Shieh Feng‐Chih Chang 《Polymer International》2004,53(2):218-224
The miscibility behaviour and hydrogen‐bonding interaction in blends of poly(2‐hydroxypropyl methacrylate) (PHPMA) with polyvinylpyrrolidone (PVP) were characterized using differential scanning calorimetry and Fourier‐transform infrared spectra. This polymer blend was miscible over the whole composition range and an unusually large positive deviation of Tg from the linearity rule was observed, indicating strong hydrogen bonding between the hydroxyl group of PHPMA and the carbonyl group of PVP. Infrared spectroscopic analysis provided positive evidence for the intra‐molecular hydrogen bonding of PHPMA and inter‐molecular hydrogen bonding between PHPMA and PVP at various compositions and temperatures. Furthermore, equilibrium constants and enthalpies of self‐association and inter‐association between functional groups in the blend of PHPMA and PVP were calculated to explain the results. Copyright © 2004 Society of Chemical Industry 相似文献
8.
An expert system for fault diagnosis in internal combustion engines using probability neural network
Jian-Da Wu Peng-Hsin Chiang Yo-Wei Chang Yao-jung Shiao 《Expert systems with applications》2008,34(4):2704-2713
An expert system for fault diagnosis in internal combustion engines using adaptive order tracking technique and artificial neural networks is presented in this paper. The proposed system can be divided into two parts. In the first stage, the engine sound emission signals are recorded and treated as the tracking of frequency-varying bandpass signals. Ordered amplitudes can be calculated with a high-resolution adaptive filter algorithm. The vital features of signals with various fault conditions are obtained and displayed clearly by order figures. Then the sound energy diagram is utilized to normalize the features and reduce computation quantity. In the second stage, the artificial neural network is used to train the signal features and engine fault conditions. In order to verify the effect of the proposed probability neural network (PNN) in fault diagnosis, two conventional neural networks that included the back-propagation (BP) network and radial-basic function (RBF) network are compared with the proposed PNN network. The experimental results indicated that the proposed PNN network achieved the best performance in the present fault diagnosis system. 相似文献
9.
Seul‐Ki Park So‐Eun Kim Dae‐Yoon Kim Shin‐Woong Kang Seunghan Shin Shiao‐Wei Kuo Seok‐Ho Hwang Seung Hee Lee Myong‐Hoon Lee Kwang‐Un Jeong 《Advanced functional materials》2011,21(11):2129-2139
Robust coatable polarizer is fabricated by the self‐assembly of lyotropic chromonic liquid crystals and subsequent photo‐polymerizing processes. Their molecular packing structures and optical behaviors are investigated by the combined techniques of microscopy, scattering and spectroscopy. To stabilize the oriented Sunset Yellow FCF (H‐SY) films and to minimize the possible defects generated during and after the coating, acrylic acid (AA) is added to the H‐SY/H2O solution and photo‐polymerized. Utilizing cross‐polarized optical microscopy, phase behaviors of the H‐SY/H2O/AA solution are monitored by varying the compositions and temperatures of the solution. Based on the experimental results of two‐dimensional wide angle X‐ray diffraction and selected area electron diffraction, the H‐SY crystalline unit cell is determined to be a monoclinic structure with the dimensions of a = 1.70 nm, b = 1.78 nm, c = 0.68 nm, α = β = 90.0° and γ = 84.5°. The molecular arrangements in the oriented H‐SY films were further confirmed by polarized Fourier‐transform infrared spectroscopy. The polymer‐stabilized H‐SY films show good mechanical and chemical stabilities with a high polarizability. Additionally, patterned polarizers are fabricated by applying a photo‐mask during the photo‐polymerization of AA, which may open new doors for practical applications in electro‐optic devices. 相似文献
10.