Homogeneous and polymorphic transformations to ordered intermetallics in nanostructured Au–Cu multilayer thin films

Journal of Materials Science - Atomic arrangements in the nanostructured grains and interfaces of thermally evaporated Au/Cu multilayer thin films on polycrystalline Si substrate have been explored...     

Performance analysis of a hybrid solar thermoelectric generator

In this paper, a theoretical model is developed to investigate the performance of the hybrid solar thermoelectric generator (HSTEG) system, which is designed without (B-HSTEG) and with an evacuated glass tube (V-HSTEG). The heat loss, power output, thermal efficiency, and electrical efficiency of the B-HSTEG/V-HSTEG system are evaluated by analyzing the design parameters such as geometric solar concentration ratio, thermoelectric figure of merit, and cold-side inlet fluid temperature. The performance of the B-HSTEG is compared with the V-HSTEG system using two heat transfer fluids: water and Therminol VP-1. The maximum electrical efficiency of the B-HSTEG and V-HSTEG is estimated to be 12.2 and 15.6% (ZT = 3) with a corresponding thermal efficiency of about 61.9 and 60.3%, respectively. Overall, this paper provides a systematic performance analysis of HSTEG systems.     

Nanoindentation based fracture studies of ITO coating

Nano-scale load (P) dependency of fracture toughness (K_1C) of indium tin oxide (ITO) coating on silicon (Si) substrate is evaluated by nanoindentation based direct and energy methods. A Berkovich triangular diamond nanoindenter is used with nine different P values e.g., 10, 15, 20, 30, 40, 50, 100, 150 and 200 mN. Extensive utilization of both optical microscopy (OM) and field emission scanning electron microscopy (FESEM) techniques reveal that up to P ≤ 40 mN only the sharp radial cracks form from three corners of the nanoindent. However, for P > 40 mN, multiple cracks occur over and above the radial cracks. Finally, at P: 150–200 mN coating gets chipped off from the substrate. The K_1C values of the ITO coating are calculated on the basis of both the conventional radial crack length measurement based method and the strain energy release based method. The K_1C values are strongly sensitive to variations in P. Further, the strain energy method results in higher magnitudes of the K_1C values.     

Presence of Potential G-Quadruplex RNA-Forming Motifs at the 5′-UTR of PP2Acα mRNA Repress Translation

RNA G-quadruplex (G4)-forming motifs present at the 5′-UTR of the protein phosphatase (PP2Ac) gene are the regulatory targets of the fragile X mental retardation protein (FMRP), which is weakly expressed in Fragile X patients. Herein, we report that the existence of such G4-forming sequence represses the translation of the PP2Acα gene. This study opens therapeutic avenues to design small molecule ligands that mimic the function of the FMRP.     

A study on landslides and subsurface piping,facilitated by dykes,using vertical electrical sounding and δO<Superscript>18</Superscript> and δH<Superscript>2</Superscript> stable isotopes

A combination of vertical electrical sounding (VES) and δO¹⁸ and δH² stable isotope geochemistry is used in this study to trace out the extension of a dyke and for deciphering the subsurface piping phenomena in a landslide-affected hamlet, Pasukadavu, in the Western Ghats of Kerala, India. VES was successful in extracting three to four different subsurface layers characterized by differing resistivity. Two VES sections were prepared from 24 different VES locations, each one for understanding the dyke extension and for delineating subsurface conduits. The dyke was characterized by high resistivity of 800–5000 Ω.m and shows varying thickness. In the second profile, the void zone, which is characteristic of piping, is delineated through a low resistivity zone (75 to 350 Ω.m). δO¹⁸ and δH² stable isotopes collected along the second VES profile show the same chemistry, indicating that it is the same water which flows all along the VES profile 2. A four-stage conceptual model was developed to illustrate and narrate the sequence of development of the piping phenomena and landslide activity.     

Nucleic Acid Bioconjugates in Cancer Detection and Therapy

Nucleoside‐ and nucleotide‐based chemotherapeutics have been used to treat cancer for more than 50 years. However, their inherent cytotoxicities and the emergent resistance of tumors against treatment has inspired a new wave of compounds in which the overall pharmacological profile of the bioactive nucleic acid component is improved by conjugation with delivery vectors, small‐molecule drugs, and/or imaging modalities. In this manner, nucleic acid bioconjugates have the potential for targeting and effecting multiple biological processes in tumors, leading to synergistic antitumor effects. Consequently, tumor resistance and recurrence is mitigated, leading to more effective forms of cancer therapy. Bioorthogonal chemistry has led to the development of new nucleoside bioconjugates, which have served to improve treatment efficacy en route towards FDA approval. Similarly, oligonucleotide bioconjugates have shown encouraging preclinical and clinical results. The modified oligonucleotides and their pharmaceutically active formulations have addressed many weaknesses of oligonucleotide‐based drugs. They have also paved the way for important advancements in cancer diagnosis and treatment. Cancer‐targeting ligands such as small‐molecules, peptides, and monoclonal antibody fragments have all been successfully applied in oligonucleotide bioconjugation and have shown promising anticancer effects in vitro and in vivo. Thus, the application of bioorthogonal chemistry will, in all likelihood, continue to supply a promising pipeline of nucleic acid bioconjugates for applications in cancer detection and therapy.