A Quality Software Process for Rapid Application Development

Software organizations can significantly improve the quality of their output if they have a defined and documented software process, together with the appropriate techniques and tools to measure its effectiveness. Without a defined process it is impossible to measure success or focus on how development capability can be enhanced. To date, a number of software process improvement frameworks have been developed and implemented. However, most of these models have been targeted at large-scale producers. Furthermore, they have applied to companies who use traditional development techniques. Smaller companies and those operating in development areas where speed of delivery is paramount have not, as yet, had process improvement paradigms available for adoption.This study examined the software process in a small company and emerged with the recommendation of the use of the Dynamic Systems Development Method (DSDM) and the Personal Software Process (PSP) for achieving software process improvement.     

P-splines quantile regression estimation in varying coefficient models

Quantile regression, as a generalization of median regression, has been widely used in statistical modeling. To allow for analyzing complex data situations, several flexible regression models have been introduced. Among these are the varying coefficient models, that differ from a classical linear regression model by the fact that the regression coefficients are no longer constant but functions that vary with the value taken by another variable, such as for example, time. In this paper, we study quantile regression in varying coefficient models for longitudinal data. The quantile function is modeled as a function of the covariates and the main task is to estimate the unknown regression coefficient functions. We approximate each coefficient function by means of P-splines. Theoretical properties of the estimators, such as rate of convergence and an asymptotic distribution are established. The estimation methodology requests solving an optimization problem that also involves a smoothing parameter. For a special case the optimization problem can be transformed into a linear programming problem for which then a Frisch–Newton interior point method is used, leading to a computationally fast and efficient procedure. Several data-driven choices of the smoothing parameters are briefly discussed, and their performances are illustrated in a simulation study. Some real data analysis demonstrates the use of the developed method.     

Polysaccharides as excipients for colon-specific coatings. Permeability and swelling properties of casted films

Oligosaccharides such as inulin (In) and polysaccharides such as galactomannans, combined with polymethacrylates on isolated films for film coatings, were obtained from aqueous-based solvents and investigated as potential vehicles for colonic drug delivery. These compositions, which are susceptible to fermentation by colonic microflora, constitute promising excipients for the development of new colon-specific therapeutic systems. The characteristics of several compositions have been demonstrated in permeability and swelling studies on isolated films composed of a polymethacrylate associated with In or galactomannans of mesquite seed gum (MSG). Results reported prove a dependency of the properties of mixed films on the polymethacrylate-polysaccharide concentration ratio and on the composition of the dissolution media. An increase in permeability through the mixed films was observed in a simulated colonic environment for the following compositions: Eudragit®RS30D-MSG 70 : 30 w/w; Eudragit® RS30D-In 90 : 10 w/w; Eudragit®RS30D-In 76 : 24 w/w.     

The in Vitro Pfnetration of Hydrophilic and Lipophilic Drugs from Transparent Oil-Water Gels Through Excised Human Epidermis: A Comparative Study with Other Dermatological Vehicles

Within the scope OF evaluating transparent oil-water gels as dermatological vehicles, the percutaneous absorption of both a hydrophilic drug, tetracaine hydrochloride, and a lipophilic drug, benzyl nicotinate, is studied using excised human epidermis. From a comparison of the results with those of release experiments, it appears that in most cases the penetration of both drugs through the epidermis occurs at a much lower rate than their release from the vehicles. This indicates that the penetration process constitutes the rate limiting step.

For both drugs the penetration rate from the transparent oil-water gel through human epidermis is comparable to those from other commonly used vehicles. Due to the higher lipophilicity of benzyl nicotinate, however, its penetration occurs faster than for tetracaine hydrochloride. As to the influence OF drug concentration in the vehicle on penetration rate, the results do not provide a decisive answer.     

Nonparametric estimation of mean and dispersion functions in extended generalized linear models

We study joint nonparametric estimators of the mean and the dispersion functions in extended double exponential family models. The starting point is the exponential family and the generalized linear models setting. The extended models allow for both overdispersion and underdispersion, or even a combination of both. We simultaneously estimate the dispersion function and the mean function by using P-splines with a difference type of penalty to avoid overfitting. Special attention is given to the smoothing parameter selection as well as to implementation issues. The performance of the method is investigated via simulations. A comparison with other available methods is made. We provide applications to several sets of data, including continuous data, counts and proportions.     

Digital radiographic equipment in the Belgian dental office

A survey was performed among Belgian dentists to evaluate the use and management of digital radiographic equipment. The majority of respondents work as general dental practitioners. One out of eight sets of equipment for extraoral exposures is digital. For intraoral radiography, 30% of the equipment is digital. While exposure time is reduced by about 50% for digital intraoral radiography compared with conventional radiography, no differences can be found between different conventional film speed classes. Appropriate collimation of the radiation beam is only sparingly used. Beam aiming devices to hold the film and position the radiation beam are not used by the majority of dentists. While 25% of the respondents stand behind a protective wall during exposure, 8% of dentists remain next to the patient during exposure while assisting in holding the film inside the mouth. A minority of the latter practitioners wear lead aprons.     

Automated Particle Analysis of Populations of Silver Halide Microcrystals by Electron Probe Microanalysis under Cryogenic Conditions

An automated particle analysis routine is implemented on an electron microprobe for analyzing the chemical composition and projective area of populations of individual silver halide microcrystals. An LN2 cryostage is used to prevent material degradation due to reaction with the impinging electron beam. The background in the EDX spectra is lowered by depositing the microcrystals on a carbon-coated copper grid, mounted in a transmission holder. The ILα/AgLα net X-ray intensity ratio, obtained from a spectrum-fitting algorithm, is used to determine the crystal composition by means of a standard-based calibration curve. The uncertainty on the concentration measurement of individual microcrystals is calculated using the uncertainties on the net X-ray counts and the uncertainties on the calibration curve. The area measurement is optimized by introducing a gray value histogram correction on each individual measurement. Overlapping microcrystals are scrapped from the analysis by defining a maximum shape factor, against which the shape factor of the microcrystal is tested. To minimize problems with drift of the cryostage, spectrum acquisition is carried out immediately after a single microcrystal has been located, based on the backscattered electron image. Several applications are discussed.     

Power and Speed-Efficient Code Transformation of Video Compression Algorithms for RISC Processors

Upcoming multi-media compression applications will require high memory bandwidth. In this paper, we estimate that a software reference implementation of an MPEG-4 video decoder typically requires 200 Mtransfers/s to memory to decode 1 CIF (352×288) Video Object Plane (VOP) at 30 frames/s. This imposes a high penalty in terms of power but also performance.However, we also show that we can heavily improve on the memory transfers, without sacrificing speed (even gaining about 10% on cache misses and cycles for a DEC Alpha), by aggressive code transformations. For this purpose, we have manually applied an extended version of our data transfer and storage exploration (DTSE) methodology, which was originally developed for custom hardware implementations.     

Numerical and experimental study of the multi-axial quasi-static strength of clinched connections

Conventionally, the mechanical strength of clinched connections is determined by a single shear lap test and/or a pull-out test. However, in most practical applications a combination of shear and pull-out is exerted on the clinched joint. This paper deals with the development of an Arcan-like device which enables to introduce various shear/tensile ratios in a clinched assembly. An experimental survey of the multi-axial behaviour of a non-cutting single-stroke round clinched connection of two DC05 sheets, which is mild deep drawing steel, is conducted with this modified Arcan setup. These experimental results are used to check the validity of numerical models that predict the strength under multi-axial loading. Since the forming of a clinch is a fairly complex sheet metal operation, a good knowledge of the plastic material properties and the frictional behaviour is of the utmost importance to perform a sufficiently accurate FEA simulation. The impact of these factors on the multi-axial loading behaviour of the DC05–DC05 connection is investigated.