Fresh surgical specimens of tumors from 60 patients with previously untreated non-small cell lung carcinoma (NSCLC) who underwent radical surgery between January 1991 and October 1992 were investigated by means of flow-cytometry. The nuclear DNA measurement was carried out using a Facscan (Becton, Dickinson, USA). Analysis of the DNA content was performed in all 60 patients whilst cell cycle analysis was possible in 41 cases (68.3%). Forty-two of the 60 cases (70%) were aneuploid and 18 (30%) were diploid. The overall mean value of DNA index was 1.5. Diploid NSCLC were compared with aneuploid tumors: no significant differences in age distribution, sex ratio, histology and staging were found between the two groups (P > 0.05). An S-phase proportion of more than 10% was found in 30 out of 41 patients (73.2%). Early cancer deaths were reported in four patients (6.6%): the aneuploidy rate was very close in these patients (75%) and in the remaining surviving patients (69.6%). An S-phase proportion of more than 10% was found in 100% of early cancer deaths and in 70.2% of the remaining cases; such a difference seems of some importance although it was not statistically significant (P = 0.071). In conclusion, flow-cytometry studies seem to be a useful tool in the understanding of the biological behavior of patients with NSCLC. In the present prospective report there were no significant correlations between DNA measurements and clinical outcome, however, these results suggest that a high S-phase proportion should be seen as a possible prognostic indicator.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
In conclusion, our study showed that serum G.G.T rises in cholestasis, and the rise is significantly higher in extraphepatic cholestasis as compared to intrahepatic cholestasis. Serum G.G.T has not shown any superiority over alkaline phosphatase in the evaluation of cholestatic liver disease. However, two considerations must caution against the use of serum G.G.T. alone for evaluation of hepatobiliary disease. The first of these is the lack of specificity for hepatobiliary disease. Serum G.G.T. activity can be elevated in some non-hepatic disorders such as acute pancreatitis, congestive cardiac failure, myocardial infarction, diabetes mellitus and alcoholism. Determination of serum G.G.T. in these patients is of no value. Second, the possibility that changes in serum G.G.T. activity results from drug administration in man. 相似文献
Indium tin oxide (ITO) nano powders of different compositions (In: Sn = 90: 10, 70: 30 and 50: 50) were prepared by heat treatment
(300-450°C) of mixed hydroxides of In(III) and Sn(IV). The hydroxides were obtained by the reaction of aq. NH3 with mixed aq. solutions of In(NO3)3 and SnCl4. FTIR and TG/DTA studies revealed that powders existed as In(OH)3H2O—SnO3H2H2O in the solid state and then they transformed to In2O3—SnO2 via some metastable intermediates after 300°C. Cubic phase of In2O3 was identified by XRD for the oxides up to 30% of Sn. Particle size measurements of the solid dispersed in acetone and SEM
study for microstructure showed that the oxides were in the nano range (55-75 nm) whereas the size range determined from Debye-Scherrer
equation were 11–24 nm. 相似文献
The conventional crosscorrelation function (XCF) used in temporal and spatial displacement measurement is unable to provide satisfactory results when linear distortion is also present in the signals. A 'nested' correlation function (NCF) is proposed which produces accurate results, when the distortion is dispersive, with negligible computational overhead.<> 相似文献
Copper(II), nickel(II) and zinc(II) complexes of amidate ligand 1,2-bis(2-hydroxybenzamido)ethane(H2hybe) encapsulated in the super cages of zeolite-Y have been prepared and characterized by spectroscopic studies and thermal as well as X-ray diffraction (XRD) patterns. These complexes catalyze the liquid-phase hydroxylation of phenol with H2O2 to catechol as a major product and hydroquinone as a minor product. Considering the concentration of substrate and oxidant, amount of catalyst, temperature of the reaction and volume of solvent, a best-suited reaction condition has been optimized to get maximum hydroxylation. Under the optimized reaction conditions, [Cu(hybe)]-Y has shown the highest conversion of 40% after 6h, which is followed by [Ni(hybe)]-Y with 37% conversion and [Zn(hybe)]-Y has shown the poorest performance with 33% conversion. All these catalysts are more selective towards catechol formation (90%), irrespective of their catalytic performance. 相似文献
The present work intends to investigate dynamic behaviour of draft gear using finite element method. The longitudinal force that the draft gear absorbs usually leads to the failure of its components, especially, the load bearing draft pads. Dynamic behaviour of an individual draft pad and a draft gear is determined and characterized with exciting frequencies and corresponding mode shapes. The effect of compressive prestress load on the dynamic behaviour of an individual draft pad is also determined as the draft pads in assembled state are under constant axial compressive force in the draft gear. The vibration characteristics of individual draft pad are compared with draft pads that are part of draft gear. The modal analysis gives us a basis for subjecting a draft pad to higher frequency loading for determining its fatigue behaviour.
In the request-based scheme, a patching channel is initiated on arrival of a request in an interarrival time of two adjacent multicast channels. If two requests are received in a short duration in an interarrival time, two patching channels are needed to service them. Both these channels deliver almost the same data, thus, wasting the bandwidth. This problem may be addressed in two ways: using higher level patching technique, or forcing the first request to wait for the second one. Using higher level patching technique makes the system more complex and thus usually not preferred. In the second case, the bandwidth usage certainly reduces, but the length of the waiting time by the first request for the second request is the main issue. In this paper, this issue is addressed by dividing the video duration into uniform time slots such that there is at least one request in a time slot for initiating the patching channel. The proposed scheme is named as Video Data Delivery using Slotted Patching. In this scheme, the patching channels download much less video data than the request-based scheme and thus require less bandwidth. This scheme may not provide immediate services to all users unlike the request-based scheme, but the user's waiting can be made arbitrarily small without using much resources unlike the request-based scheme. 相似文献
Microsystem Technologies - In this paper, we have designed and simulations of RF MEMS shunt switch. The electro-mechanical and electromagnetic analysis of the switch have been done using COMSOL... 相似文献