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Developing independence involves mastering the tasks of each life transition. Those more anxious about developing independence will become more invested in the normative tasks of each transition, and this anxiety will spread to the domain represented by these tasks. In Study 1, Honors College students expressed their anxiety about developing independence in academic performance at the beginning of college when this was the normative task and in social relationships after college when this was the normative task. This anxiety could be distinguished from other (e.g., academic) anxiety. In Study 2, sorority women expressed anxiety about developing independence in family and sorority relationships. Data demonstrate the social construction of anxiety and the dynamics of personality change. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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Oliver Schmutzler Sebastian Graf Nils Behm Wael Y. Mansour Florian Blumendorf Theresa Staufer Christian Krnig Dina Salah Yanan Kang Jan N. Peters Yang Liu Neus Feliu Wolfgang J. Parak Anja Burkhardt Elisabetta Gargioni Sabrina Gennis Sharah Chandralingam Finn Heg Wolfgang Maison Kai Rothkamm Florian Schulz Florian Grüner 《International journal of molecular sciences》2021,22(7)
Quantitative cellular in vitro nanoparticle uptake measurements are possible with a large number of different techniques, however, all have their respective restrictions. Here, we demonstrate the application of synchrotron-based X-ray fluorescence imaging (XFI) on prostate tumor cells, which have internalized differently functionalized gold nanoparticles. Total nanoparticle uptake on the order of a few hundred picograms could be conveniently observed with microsamples consisting of only a few hundreds of cells. A comparison with mass spectroscopy quantification is provided, experimental results are both supported and sensitivity limits of this XFI approach extrapolated by Monte-Carlo simulations, yielding a minimum detectable nanoparticle mass of just 5 pg. This study demonstrates the high sensitivity level of XFI, allowing non-destructive uptake measurements with very small microsamples within just seconds of irradiation time. 相似文献
5.
Andrea Kunova Luca Palazzolo Fabio Forlani Giorgia Catinella Loana Musso Paolo Cortesi Ivano Eberini Andrea Pinto Sabrina Dallavalle 《International journal of molecular sciences》2021,22(7)
The increasing emergence of fungicide-resistant pathogens requires urgent solutions for crop disease management. Here, we describe a structural investigation of new fungicides obtained by combining strobilurin and succinate dehydrogenase inhibitor pharmacophores. We identified compounds endowed with very good activity against wild-type Pyricularia oryzae, combined in some cases with promising activity against strobilurin-resistant strains. The first three-dimensional model of P. oryzae cytochrome bc1 complex containing azoxystrobin as a ligand was developed. The model was validated with a set of commercially available strobilurins, and it well explains both the resistance mechanism to strobilurins mediated by the mutation G143A and the activity of metyltetraprole against strobilurin-resistant strains. The obtained results shed light on the key recognition determinants of strobilurin-like derivatives in the cytochrome bc1 active site and will guide the further rational design of new fungicides able to overcome resistance caused by G143A mutation in the rice blast pathogen. 相似文献
6.
Elisabeth M. Haberl Thomas S. Weiss Georg Peschel Kilian Weigand Nikolai Khler Josch K. Pauling Jürgen J. Wenzel Marcus Hring Sabrina Krautbauer Gerhard Liebisch Christa Buechler 《International journal of molecular sciences》2021,22(10)
Hepatocellular carcinoma (HCC) still remains a difficult to cure malignancy. In recent years, the focus has shifted to lipid metabolism for the treatment of HCC. Very little is known about hepatitis B virus (HBV) and C virus (HCV)-related hepatic lipid disturbances in non-malignant and cancer tissues. The present study showed that triacylglycerol and cholesterol concentrations were similar in tumor adjacent HBV and HCV liver, and were not induced in the HCC tissues. Higher levels of free cholesterol, polyunsaturated phospholipids and diacylglycerol species were noted in non-tumorous HBV compared to HCV liver. Moreover, polyunsaturated phospholipids and diacylglycerols, and ceramides declined in tumors of HBV infected patients. All of these lipids remained unchanged in HCV-related HCC. In HCV tumors, polyunsaturated phosphatidylinositol levels were even induced. There were no associations of these lipid classes in non-tumor tissues with hepatic inflammation and fibrosis scores. Moreover, these lipids did not correlate with tumor grade or T-stage in HCC tissues. Lipid reprogramming of the three analysed HBV/HCV related tumors mostly resembled HBV-HCC. Indeed, lipid composition of non-tumorous HCV tissue, HCV tumors, HBV tumors and HBV/HCV tumors was highly similar. The tumor suppressor protein p53 regulates lipid metabolism. The p53 and p53S392 protein levels were induced in the tumors of HBV, HCV and double infected patients, and this was significant in HBV infection. Negative correlation of tumor p53 protein with free cholesterol indicates a role of p53 in cholesterol metabolism. In summary, the current study suggests that therapeutic strategies to target lipid metabolism in chronic viral hepatitis and associated cancers have to consider disease etiology. 相似文献
7.
Sara M. dos S. Pizzatto Fernando Otavio Pizzatto Elidio Angioletto Sabrina Arcaro Eduardo Junca Oscar R. Klegues Montedo 《International Journal of Applied Ceramic Technology》2021,18(5):1734-1742
The effects of porous ceramic plates on the thermal behavior of ventilated façades were evaluated, and the results are presented herein. Thermal behavior in a ventilated façade of specimens containing 40 wt% of lime mud and a firing temperature of 1100°C was evaluated and compared with a commercial porcelain ceramic tile, which was the reference material. An experimental apparatus was designed to evaluate the thermal performance of the studied ventilated façades. The results revealed that the ventilated façade composed of the studied porous ceramic tiles produced a greater reduction in temperature between the external environmental and the interior of a box representing a building (ΔT5) of 65.7°C, compared with the façade composed of the commercial porcelain ceramic tiles (ΔT5 = 56.0°C) and even the traditional façade (ΔT5 = 49.1°C). Thus, porous ceramic tiles based on byproducts are promising candidates for ventilated façade systems. 相似文献
8.
Transition temperatures and enthalpies and some phase diagrams of pure odd and even sodium soaps have been determined by means
of dif-ferential thermal analysis and scanning calorim-etry. Branched sodium soaps have been added for comparison.
No essential difference has been found between the number, type, and enthalpy of the transitions of the neighboring odd and
even soaps. The total enthalpy and entropy of transition are consider-ably lower than those of the corresponding par-affins
and fatty acids. The entropy of the subneat-neat and perhaps of the neat isotropic transition has an alternating character,
which suggests a different methyl end-group packing for even and odd soap. These two facts suggest that the melted soap is
still in an organized state.
Presented at the AOCS Meeting, New Orleans, May 1967. 相似文献
9.
Diffusion coefficients D of H 2 , He, O 2 , N 2 , and CO 2 in different rubbery amorphous polymeric matrices were estimated by atomistic molecular dynamics simulations at 298 K using the Einstein relationship, and compared with the relevant experimental values, where available. The simulated diffusion coefficients D of all the gases in all polymers considered almost regularly decreased with increasing molecular gas volumes and increasing polymer glass transition temperature. Further, solubility coefficients and heats of solution were obtained for all gases from Grand Canonical Monte Carlo simulations, which were also used to calculate sorption isotherms. In general, there is a good agreement between experimental and simulated values of diffusion and solubility coefficients for all gases considered. 相似文献
10.
Jose Jonathan Rubio Arias Sabrina dos Santos Bento Maria de Fátima Vieira Marques Ailton de Souza Gomes 《应用聚合物科学杂志》2021,138(8):49871
The search for more compatibility between ionic liquids (ILs) and polymer matrices in proton-exchange membrane fuel cells (PEMFCs) is one of the ways in which IL leaking from proton-exchange membranes could be minimized. In this work, it is presented the synthesis of an aromatic high temperature ionic liquid (HTIL), which, incorporated into an aromatic matrix such as sulfonated polyether ether ketone (sPEEK), is expected to diminish the IL leaking that normally affects PEMFC. Phenylethylammonium trifluoromethane sulfonate (PhetaTfO) was successfully synthesized and characterized. Its melting point of 88°C makes it to classify as a HTIL and it was employed as modifier of natural Montmorillonite, forming the phenylethylammonium intercalated montmorillonite (MmtPheta) and thus, ternary membranes containing PhetaTfO, MmtPheta, and sPEEK were prepared and characterized. Immersion tests demonstrated a higher compatibility of PhetaTfO with matrix when compared to the reference DemaTfO, which was reflected in up to 30% lower IL loss by the synthesized IL than the DemaTfO; X-rays diffraction (XRD) patterns demonstrated that the modified clay was properly dispersed inside the membranes, while dynamic mechanical analyses (DMA) results indicated a strong plasticizer effect along the increase of PhetaTfO content inside the membrane, while at the same time, the conductivity increased in an exponential manner, which permitted to identify an empiric exponential equation to evaluate the effect of concentration on ionic conductivity. The maximum conductivity obtained at IL concentrations of around 38 wt% was 0.2 mS/cm. It could expect high ionic conductivities of 10 mS/cm when the concentration of this IL is 60%; nevertheless, in order to achieve that, crosslinking treatments should be done to give the membranes enough mechanical resistance. 相似文献