The Role of Oncostatin M and Its Receptor Complexes in Cardiomyocyte Protection,Regeneration, and Failure

Oncostatin M (OSM), a member of the interleukin-6 family, functions as a major mediator of cardiomyocyte remodeling under pathological conditions. Its involvement in a variety of human cardiac diseases such as aortic stenosis, myocardial infarction, myocarditis, cardiac sarcoidosis, and various cardiomyopathies make the OSM receptor (OSMR) signaling cascades a promising therapeutic target. However, the development of pharmacological treatment strategies is highly challenging for many reasons. In mouse models of heart disease, OSM elicits opposing effects via activation of the type II receptor complex (OSMR/gp130). Short-term activation of OSMR/gp130 protects the heart after acute injury, whereas chronic activation promotes the development of heart failure. Furthermore, OSM has the ability to integrate signals from unrelated receptors that enhance fetal remodeling (dedifferentiation) of adult cardiomyocytes. Because OSM strongly stimulates the production and secretion of extracellular proteins, it is likely to exert systemic effects, which in turn, could influence cardiac remodeling. Compared with the mouse, the complexity of OSM signaling is even greater in humans because this cytokine also activates the type I leukemia inhibitory factor receptor complex (LIFR/gp130). In this article, we provide an overview of OSM-induced cardiomyocyte remodeling and discuss the consequences of OSMR/gp130 and LIFR/gp130 activation under acute and chronic conditions.     

Relationships between the presence of Johne's disease and farm and management factors in dairy cattle in England

The data collected by a postal questionnaire sent to 3772 randomly selected dairy farmers in England and the border regions in Wales were used to estimate the relationships between the presence of clinical Johne's disease and farm and management factors associated with that disease. Two binary outcomes (case reported in 1993, case reported in 1994) and 27 predictor variables were considered. Only two variables were consistently and significantly associated with clinical disease in multivariable analysis. Farms on which Channel Island breeds were predominant were associated with an increased risk of reporting disease (odds ratios (ORs) ranged from 10.9 to 12.9). The presence of farmed deer on the farm also increased the risk of reporting disease (ORs ranged from 15.2 to 209.3). There were other significant but inconsistent associations involving the source of replacements, age of first-offering hay, type of concentrate feed to calves, and calving in individual pens when the cows were at grass. Since Johne's disease is predominantly subclinical, these contributing factors may play important roles in switching subclinical infection to overt disease.     

Nanoparticle Removal Using Laser-Induced Plasma Shock Waves

Removal of sub-100 nm particles from substrates such as wafers and photo masks is an essential requirement in semiconductor, microelectronics, and nanotechnology applications. The proposed laser-induced plasma (LIP) based approach is an effective technique for removal of sub-100 nm particles, as the minimum tolerable particle on the substrates shrinks to sub-100 nm levels with each technological node. In the current study, our progress in sub-100 nm particle removal is reviewed, and the results of the kinetic theory simulations conducted to understand the dynamics of the gas molecule-nanoparticle interactions excited by the shock front are discussed. It is shown from the simulations and experiments that particles as small as sub-100 nm can be successfully detached. To explain possible mechanisms for the nanoparticle detachment in nanoscale, the concepts of rolling resistance moment and rocking motion are utilized as novel detachment mechanisms. The pressure experiments illustrate that the peak pressure levels achieved with the LIP shock wave fields are below damage thresholds of most substrate materials. The potential of the proposed approach as a practical noncontact, dry, fast, and damage-free method for removal of sub-100 nm particles is discussed.     

Segment‐aware dynamic routing for DASH flows over software‐defined networks

Most of the video streaming applications running over the Internet send video data over HTTP and provide an architecture for video clients to adapt video quality during streaming. In HTTP adaptive streaming, a raw video is encoded at various qualities, each encoded video file is divided into small segments, and the clients may change the segment quality by sending requests for segments having different qualities over time. MPEG has standardized dynamic adaptive streaming over HTTP (MPEG‐DASH) due to this tendency. In this work, we focus on DASH over software‐defined networks (SDN), and we dynamically reroute DASH flows by considering the current network capacity, available bandwidth of the paths, and bitrate of the segments in order to provide high quality of experience (QoE) and fairness among DASH clients. Simulations performed under various network conditions show that the proposed study provides higher QoE and fairness compared with the max‐flow routing approach.     

Structural,physical, and optical characterization of (Nd3+/Eu3+)-doped zinc-rich silica–borate glasses

In this study, zinc–silica–borate glass structures doped with rare earth (RE) oxides Eu₂O₃ and Nd₂O₃ were synthesized with classical melting–quenching technique. 60ZnO–10SiO₂–(30 – x)B₂O₃:xRE (x?=?0, 0.5, 1, 1.5 mol%) composition was chosen as the structure. The doping effect of two different rare earth oxides (individually) at different ratios was investigated according to the structural, physical, and optical properties of the glass structure. Structural properties of the synthesized glasses were determined with Fourier transform infrared (FTIR) device, and densities (ρ) and molar volumes (V_m) of the glasses were measured with Archimedes method, and optical properties were determined with UV–Visible (UV–Vis-NIR) device. FTIR results show that BO₃ units increased in all RE-doped glasses. While densities of the synthesized glasses varied between 3.755 and 3.941 g cm^??3, indirect bandgaps varied between 3.219 and 3.645 eV. The glass with the highest transmittance was the 1% Eu₂O₃-doped glass with a transmittance of 84%. While band edges shifted slightly toward short wavelengths in glasses doped with Nd₂O₃, they shifted to longer wavelengths in glasses doped with Eu₂O₃.