Fine particle physics and technology; some results

The new techniques of fine particle synthesis are shown to lead to better ceramic materials such as yttrium iron garnet (YIG) and ferroelectric lead zirconate titanate (PZT). The densities are greater than 99% of the theoretical density and the grain size can be easily controlled from 2 microns upwards. For YIG this means higher values of the nonlinear spin-wave excitation thresholdh _c. For PZT the result is higher values of the tensor componentd ₃₃ and poling voltage. It is also shown that the fine particle systems and the fine-grain microstructure lead to interesting physics results. For PZT the lowering of the peak dielectric constant, the increasing transition temperatures and the decreasing values ofd ₃₃ with decreasing grain size can be understood in terms of the changing low-frequency cut-off of the soft lattice vibration mode. Another interesting result is that for 2000 Å size particles of α-Fe₂O₃ the anisotropy constant is found to be 1·38 × 10² ergs/cm³ from Mössbauer measurements.     

Converting Eucalyptus biomass into ethanol: Financial and sensitivity analysis in a co-current dilute acid process. Part II

The technical and financial performance of high yield Eucalyptus biomass in a co-current dilute acid pretreatment followed by enzymatic hydrolysis process was simulated using WinGEMS^® and Excel^®. Average ethanol yield per dry Mg of Eucalyptus biomass was approximately 347.6 L of ethanol (with average carbohydrate content in the biomass around 66.1%) at a cost of $0.49 L⁻¹ of ethanol, cash cost of ∼ $0.46 L⁻¹ and CAPEX of $1.03 L⁻¹ of ethanol. The main cost drivers are: biomass, enzyme, tax, fuel (gasoline), depreciation and labor. Profitability of the process is very sensitive to biomass cost, carbohydrate content (%) in biomass and enzyme cost. Biomass delivered cost was simulated and financially evaluated in Part I; here in Part II the conversion of this raw material into cellulosic ethanol using the dilute acid process is evaluated.     

High-density PZT material

A simple sol-gel technique is shown to give >99% theoretical density Pb(Zr_xTi_l?x)O₃ ceramics with a breakdown voltage of more than 70 kV. cm^?1 at 100°C. The piezoelectric tensor coefficient d₃₃ is 293 × 10^?12 coul. newton^?1 for the x = 0.52 material. It is shown that processing parameters can be controlled easily.     

A BER Based Selection Combining Protocol for Adaptive Cooperative Cognitive Radios

This paper illustrates the performance of bit error rate based selection combining (BER-SC) protocol for adaptive cooperative cognitive radios. In the proposed framework, the unlicensed (i.e. secondary) system utilizes an adaptive mode of transmission to help the licensed (i.e. primary) system to achieve the desired quality of service in exchange for opportunistic spectrum access. The total transmission is divided in two phases. In Phase I, the primary transmitter (PT) broadcasts the data to the primary receiver (PR), which is overheard by the secondary transmitter (ST) and secondary receiver (SR). In Phase II, ST decodes the primary data and linearly combines its own data with the primary data. Using M-QAM the combined data is adaptively modulated, where M = 4, 16 or 64 depending on the received channel feedback, and relayed to PR and SR. At PR, BER-SC is employed to retrieve the primary data, and at SR interference cancellation is used to retrieve the secondary data. The analytical expressions are derived for the BER and the outage probability. The obtained results demonstrate the higher performance gains for both primary and secondary system by using adaptive mode of transmission at ST and BER-SC at PR.

     

Multigene Profiling of Circulating Tumor Cells (CTCs) for Prognostic Assessment in Treatment-Naïve Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)

The substantial biological heterogeneity of metastatic prostate cancer has hindered the development of personalized therapeutic approaches. Therefore, it is difficult to predict the course of metastatic hormone-sensitive prostate cancer (mHSPC), with some men remaining on first-line androgen deprivation therapy (ADT) for several years while others progress more rapidly. Improving our ability to risk-stratify patients would allow for the optimization of systemic therapies and support the development of stratified prospective clinical trials focused on patients likely to have the greatest potential benefit. Here, we applied a liquid biopsy approach to identify clinically relevant, blood-based prognostic biomarkers in patients with mHSPC. Gene expression indicating the presence of CTCs was greater in CHAARTED high-volume (HV) patients (52% CTC_high) than in low-volume (LV) patients (23% CTC_high; * p = 0.03). HV disease (p = 0.005, q = 0.033) and CTC presence at baseline prior to treatment initiation (p = 0.008, q = 0.033) were found to be independently associated with the risk of nonresponse at 7 months. The pooled gene expression from CTCs of pre-ADT samples found AR, DSG2, KLK3, MDK, and PCA3 as genes predictive of nonresponse. These observations support the utility of liquid biomarker approaches to identify patients with poor initial response. This approach could facilitate more precise treatment intensification in the highest risk patients.     

Tumor Necrosis Factor-α Induces a Preeclamptic-like Phenotype in Placental Villi via Sphingosine Kinase 1 Activation

Preeclampsia (PE) involves inadequate placental function. This can occur due to elevated pro-inflammatory tumor necrosis factor-α (TNF-α). In other tissues, TNF-α signals via sphingosine kinase 1 (SphK1). SphK1 hinders syncytial formation. Whether this occurs downstream of TNF-α signaling is unclear. We hypothesized that placental SphK1 levels are higher in PE and elevated TNF-α decreases syncytial function, increases syncytial shedding, and increases cytokine/factor release via SphK1 activity. Term placental biopsies were analyzed for SphK1 using immunofluorescence and qRT-PCR. Term placental explants were treated after 4 days of culture, at the start of syncytial regeneration, with TNF-α and/or SphK1 inhibitors, PF-543. Syncytialization was assessed by measuring fusion and chorionic gonadotropin release. Cell death and shedding were measured by lactate dehydrogenase release and placental alkaline phosphatase-positive shed particles. Forty-two cytokines were measured using multiplex assays. Placental SphK1 was increased in PE. Increased cell death, shedding, interferon-α2, IFN-γ-induced protein 10, fibroblast growth factor 2, and platelet-derived growth factor-AA release induced by TNF-α were reversed upon SphK1 inhibition. TNF-α increased the release of 26 cytokines independently of SphK1. TNF-α decreased IL-10 release and inhibiting SphK1 reversed this effect. Inhibiting SphK1 alone decreased TNF-α release. Hence, SphK1 partially mediates the TNF-α-induced PE placental phenotype, primarily through cell damage, shedding, and specific cytokine release.     

Artificial Neural Network Modeling of Hydrodynamics of Liquid‐Solid Circulating Fluidized Beds

Solids holdup and solids circulation rate are the two important hydrodynamic variables affected by process conditions. These two variables have a significant influence on the performance of a liquid‐solid circulating fluidized bed (LSCFB). An artificial neural network (ANN) methodology was developed and simulated to predict the performance of the LSCFB for the experimental dataset collected under various process conditions. Different statistical parameters were applied to evaluate the prominent and unique characteristic features of the ANN‐predicted parameters. The ANN model successfully predicted the experimental observations and captured the actual nonlinear behavior noticed during the experiments. Model validation confirmed that this data‐driven technique can be used to model such nonlinear systems.     

Morphotropic phase boundary in the system Pb(ZrxTi1−x)O3

The room temperature phase boundary dividing the rhombohedral and tetragonal in the solid solution system lead zirconate titanate Pb(Zr_xTi_1?x)O₃ is examined carefully using an ultrahomogeneous synthesis technique. There is no evidence for a broad transition region of co-existing phases as understood earlier but a sharp boundary located at x = 0.510 ± 0.002.