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Razina Z. Seeni Mengjia Zheng Daniel Chin Shiuan Lio Christian Wiraja Mohammad Firdaus Bin Mohd Yusoff William Teck Yeow Koh Yuchun Liu Bee Tin Goh Chenjie Xu 《Advanced functional materials》2021,31(47):2105686
Pain management during dental procedures is a cornerstone for successful daily practice. In current practice, the traditional needle and syringe injection is used to administer local anesthesia. However, the appearance of long needles and the pain associated with it often leads to dental anxiety deterring timely interventions. Microneedles (MNs) have emerged as a minimally invasive alternative to hypodermic needles and shown to be effective in transdermal drug delivery applications. In this article, the potential use of MNs for local anesthesia delivery in dentistry is explored. The development of a novel conductive MN array that can be used in combination with iontophoresis technique to achieve drug penetration through the oral mucosa and the underlying bone tissue is presented. The conductive MN array plays a dual-role, creating micro-conduits and lowering the resistance of the oral mucosa. The reduced tissue resistance further enhances the application of a low-voltage current that is able to direct and accelerate the drug molecules to target the sensory nerves supplying teeth. The successful delivery of lidocaine using this new strategy in a clinically relevant rabbit incisor model is shown to be as effective as the current gold standard. 相似文献
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Sirelkhatim Amna Mahmud Shahrom Seeni Azman Kaus Noor Haida Mohamad Ann Ling Chuo Bakhori Siti Khadijah Mohd Hasan Habsah Mohamad Dasmawati 《纳微快报(英文)》2015,7(3):219-242
Nano-Micro Letters - Antibacterial activity of zinc oxide nanoparticles (ZnO-NPs) has received significant interest worldwide particularly by the implementation of nanotechnology to synthesize... 相似文献
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A Swellable Microneedle Patch to Rapidly Extract Skin Interstitial Fluid for Timely Metabolic Analysis
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Hao Chang Mengjia Zheng Xiaojun Yu Aung Than Razina Z. Seeni Rongjie Kang Jingqi Tian Duong Phan Khanh Linbo Liu Peng Chen Chenjie Xu 《Advanced materials (Deerfield Beach, Fla.)》2017,29(37)
Skin interstitial fluid (ISF) is an emerging source of biomarkers for disease diagnosis and prognosis. Microneedle (MN) patch has been identified as an ideal platform to extract ISF from the skin due to its pain‐free and easy‐to‐administrated properties. However, long sampling time is still a serious problem which impedes timely metabolic analysis. In this study, a swellable MN patch that can rapidly extract ISF is developed. The MN patch is made of methacrylated hyaluronic acid (MeHA) and further crosslinked through UV irradiation. Owing to the supreme water affinity of MeHA, this MN patch can extract sufficient ISF in a short time without the assistance of extra devices, which remarkably facilitates timely metabolic analysis. Due to covalent crosslinked network, the MN patch maintains the structure integrity in the swelling hydrated state without leaving residues in skin after usage. More importantly, the extracted ISF metabolites can be efficiently recovered from MN patch by centrifugation for the subsequent offline analysis of metabolites such as glucose and cholesterol. Given the recent trend of easy‐to‐use point‐of‐care devices for personal healthcare monitoring, this study opens a new avenue for the development of MN‐based microdevices for sampling ISF and minimally invasive metabolic detection. 相似文献
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Ling Chuo Ann Shahrom Mahmud Siti Khadijah Mohd Bakhori Amna Sirelkhatim Dasmawati Mohamad Habsah Hasan Azman Seeni Rosliza Abdul Rahman 《Ceramics International》2014
The antibacterial responses of zinc oxide (ZnO) structures against Staphylococcus aureus, Pseudomonas aeruginosa, and Streptococcus pyogenes were investigated. Two ZnO powder samples, one with rod-like (ZnO-1) and the other with plate-like (ZnO-2) structures, were characterized for their morphological, structural, and optical properties. The rods were 30–120 nm in diameter, and the plates were 40–100 nm thick. XRD results revealed the wurtzite crystallinity of ZnO with average crystallite sizes of 33.72 (ZnO-1) and 39.25 (ZnO-2) nm. ZnO-2 possessed a relatively higher green photoluminescence than that of ZnO-1, suggesting a relatively higher amount of oxygen vacancies in ZnO-2 structures. Optical density measurements showed that both ZnO samples inhibited the growth of S. aureus, P. aeruginosa, and S. pyogenes by 29–98% after 24 h of treatment. The most dramatic growth inhibition was observed in S. pyogenes with 96% and 98% inhibition for ZnO-1 and ZnO-2, respectively, leading to a probable bactericidal phenomenon. The toxicological effect on S. pyogenes was probably due to the absence of catalase, making the bacteria vulnerable to the harmful reactive oxygen species (ROS) released by ZnO. ZnO-1 induced higher inhibition toward S. aureus and P. aeruginosa than that of ZnO-2 because of the smaller particle size of rod structures compared to plate and slab structures. The adhesion of ZnO particles on the membrane of bacteria could be the underlying cause of zinc toxicity effect towards the bacteria. ZnO-1 possessed larger surface area and provided higher amount of zinc atom, thereby inducing higher level of toxicity toward the bacteria. Two possible mechanisms were proposed to explain the inhibition of bacteria, namely, ROS toxicity toward cellular constituents and interaction of zinc with bacteria membrane through adhesion of ZnO particle. Several ZnO morphological-antibacterial correlations were presented in this work. 相似文献
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R. Rajesh Kanna K. Sakthipandi S.M. Seeni Mohamed Aliar N. Lenin M. Sivabharathy 《中国稀土学报(英文版)》2018,36(12)
Copper and rare earth-doped (RE = La, Gd, Nd) CuFe1.85RE0.15O4 nanoferrites were prepared using the sonochemical method. The effective doping of rare-earth (La3+, Nd3+, Gd3+) ions with copper nanoferrites was confirmed by X-ray diffraction. The tetrahedral and octahedral sites of the nanoferrites were identified through the Fourier transform infrared spectra. The doping of rare-earth elements enhances the optical bandgap energy of the nanoferrites that are observed through Ultraviolet–DRS spectra. The oxidation state of the elements Cu 2p, La 3d, Nd 3d, Gd 3d, Fe 2p and O 1s was analyzed. Scanning electron microscopy images indicate a spherical morphology with agglomeration to some elongate. The values of dielectric constant and conductivity decrease considerably due to doping rare-earth ions in copper nanoferrites. Low saturation magnetization and high coercivity values of rare earth-doped copper nanoferrites are observed from the typical hysteresis curves. 相似文献
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Functionalization of hydroxyl terminated polybutadiene with biologically active fluorescent molecule
R. Murali Sankar Subhadeep Saha K. Seeni Meera Tushar Jana 《Bulletin of Materials Science》2009,32(5):507-514
A biologically active molecule, 2-chloro-4,6-bis(dimethylamino)-1,3,5-triazine (CBDT), has been covalently attached at the terminal carbon atoms of the hydroxyl terminated
polybutadiene (HTPB) backbone. The modification of HTPB backbone by CBDT molecule does not affect the unique physico-chemical
properties such as fluidity, hydroxyl value and microstructure of the parent HTPB. The formation of hydrogen bonding between
the terminal hydroxyl groups and the nitrogen atoms of triazine moiety is the driving force for the terminal attachment chemistry.
The functionalized HTPB (HTPB-CBDT) shows a strong fluorescence emission at 385 nm. 相似文献
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Mogana Das Murtey Azman Seeni 《Journal of the science of food and agriculture》2020,100(12):4347-4352
Rice serves as a staple food for one-half of the global population. However, rice production, particularly the rice milling process, results in a substantial amount of paddy waste products (e.g. bran, husk and straw) annually. Because the potentials of bran have been extensively explored in prior studies, the present review focuses exclusively on the phytochemical analysis and pharmacological potentials of husk and straw. This comprehensive review establishes a solid foundation for promoting husk and straw as medicinal substances given their promising pharmacological potentials as bioactive compound sources with therapeutic functions. © 2020 Society of Chemical Industry 相似文献
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