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Yehoon Kim Seungjoo Haam Woo-Sik Kim Kee-Kahb Koo 《Korean Journal of Chemical Engineering》2003,20(6):1111-1117
Crystallization of L-ornithine-L-aspartate (LOLA) by drowning out was performed for the production of the anhydrous form of
LOLA. The needle-like LOLA crystals were formed and spherically agglomerated during precipitation in a semibatch crystallizer.
The primary crystal size in the agglomerate remains unchanged after completion of the crystallization. Therefore, the agglomeration
process of primary crystals played an important role for controlling LOLA crystal size. The agglomeration of LOLA crystals
was governed by not only the physico-chemical parameters such as the temperature and feed concentration, but also the hydrodynamic
parameters such as agitation speed and feeding rate. The crystal size and the shape have been shown to be important factors
in product impurity and flowability. Thus, the optimum condition of LOLA crystallization process by drowning-out could be
obtained. 相似文献
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Sang‐Yoon Kim Jaemoon Yang Bongjune Kim Jungmin Park Jin‐Suck Suh Yong‐Min Huh Seungjoo Haam Jungho Hwang 《Small (Weinheim an der Bergstrasse, Germany)》2013,9(13):2325-2330
An electrohydrodynamic atomization (EHDA) system that generates an electrospray can achieve particle formation and encapsulation by accumulating an electric charge on liquid flowing out from the nozzle. A novel coaxial EHDA system for continuous fabrication of water‐stable magnetic nanoparticles (MNPs) is established, based on a cone‐jet mode of electrospraying. Systemic variables, such as flow rates from dual nozzles and inducing voltages, are controlled to enable the preparation of water‐soluble MNPs coated by polysorbate 80. The PEGylated MNPs exhibit water stability. The magnetic resonance imaging potential of these MNPs is confirmed by in vivo imaging using a gastric cancer xenograft mouse model. Thus, this advanced coaxial EHDA system demonstrates remarkable capabilities for the continuous encapsulation of MNPs to render them water‐stable while preserving their properties as imaging agents. 相似文献
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Junghyun Nam Seungjoo Kim Dongho Won 《Communications Letters, IEEE》2005,9(5):429-431
In this letter, we show that Bresson-Chevassut-Essiari-Pointcheval's Group Key Agreement scheme does not meet the main security properties: implicit key authentication, forward secrecy and known key security. Also, we propose an improved version, which fixes the security flaws, found in the scheme. 相似文献
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We synthesized novel fluorescent magnetic silica nanoparticles (FMSNPs) containing large magnetic components for biomedical application. By employing assemblies of magnetic nanoparticles as kernels against FMSNPs, both the saturation of magnetization and the magnetic resonance (MR) signal intensity were significantly enhanced. Furthermore, the cellular binding of FMSNPs was improved by introducing a positive charge on the surface of the FMSNPs, and fluorescent dyes on the surface of FMSNPs enable optical imaging of sub-cellular regions. 相似文献
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The work function of polyaniline nanoparticles in the emeraldine base state was determined by Kelvin probe force microscopy to be ~270 meV higher than that of similar nanoparticles in the emeraldine salt state. Normal tapping mode atomic force microscopy could not be used to distinguish between the particles due to their similar morphologies and sizes. Moreover, other potential measurement systems, such as using zeta potentials, were not suitable for the measurement of surface charges of doped nanoparticles due to their encapsulation by interfering chemical groups. Kelvin probe force microscopy can be used to overcome these limitations and unambiguously distinguish between the bare and doped polyaniline nanoparticles. 相似文献
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Bongjune Kim Jaemoon Yang Myeonghwan Hwang Jihye Choi Hyun-Ouk Kim Eunji Jang Jung Hwan Lee Sung-Ho Ryu Jin-Suck Suh Yong-Min Huh Seungjoo Haam 《Nanoscale research letters》2013,8(1):399
Nucleic acid-based aptamers have been developed for the specific delivery of diagnostic nanoprobes. Here, we introduce a new class of smart imaging nanoprobe, which is based on hybridization of a magnetic nanocrystal with a specific aptamer for specific detection of the angiogenic vasculature of glioblastoma via magnetic resonance (MR) imaging. The magnetic nanocrystal imaging core was synthesized using the thermal decomposition method and enveloped by carboxyl polysorbate 80 for water solubilization and conjugation of the targeting moiety. Subsequently, the surface of the carboxylated magnetic nanocrystal was modified with amine-functionalized aptamers that specifically bind to the vascular growth factor receptor 2 (VEGFR2) that is overexpressed on angiogenic vessels. To assess the targeted imaging potential of the aptamer-conjugated magnetic nanocrystal for VEGFR2 markers, the magnetic properties and MR imaging sensitivity were investigated using the orthotopic glioblastoma mouse model. In in vivo tests, the aptamer-conjugated magnetic nanocrystal effectively targeted VEGFR2 and demonstrated excellent MR imaging sensitivity with no cytotoxicity. 相似文献
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Point‐of‐Care Diagnostics: Host Cell Mimic Polymersomes for Rapid Detection of Highly Pathogenic Influenza Virus via a Viral Fusion and Cell Entry Mechanism (Adv. Funct. Mater. 34/2018) 下载免费PDF全文