Blood flow in the rabbit aortic arch and descending thoracic aorta

The distribution of atherosclerotic lesions within the rabbit vasculature, particularly within the descending thoracic aorta, has been mapped in numerous studies. The patchy nature of such lesions has been attributed to local variation in the pattern of blood flow. However, there have been few attempts to model and characterize the flow. In this study, a high-order continuous Galerkin finite-element method was used to simulate blood flow within a realistic representation of the rabbit aortic arch and descending thoracic aorta. The geometry, which was obtained from computed tomography of a resin corrosion cast, included all vessels originating from the aortic arch (followed to at least their second generation) and five pairs of intercostal arteries originating from the proximal descending thoracic aorta. The simulations showed that small geometrical undulations associated with the ductus arteriosus scar cause significant deviations in wall shear stress (WSS). This finding highlights the importance of geometrical accuracy when analysing WSS or related metrics. It was also observed that two Dean-type vortices form in the aortic arch and propagate down the descending thoracic aorta (along with an associated skewed axial velocity profile). This leads to the occurrence of axial streaks in WSS, similar in nature to the axial streaks of lipid deposition found in the descending aorta of cholesterol-fed rabbits. Finally, it was observed that WSS patterns within the vicinity of intercostal branch ostia depend not only on local flow features caused by the branches themselves, but also on larger-scale flow features within the descending aorta, which vary between branches at different locations. This result implies that disease and WSS patterns in the vicinity of intercostal ostia are best compared on a branch-by-branch basis.     

Antioxidants for vegetable oils

Several chemical compounds having antioxidant efficacy in food fats and oils and cleared for food use by governmental regulatory agencies are available for such use by vegetable oil processors in many nations of the world. These antioxidants are reviewed with particular attention to major benefits and possible shortcomings they may afford when added to vegetable oils. Some guidelines in selecting antioxidants to achieve optimum results are offered. Also, precautions to be observed in adding antioxidants to fats and oils are discussed.     

Influence of glucagon replacement on the hyperglycemic and hyperketonemic response to prolonged somatostatin infusion in normal man

Somatostatin was infused for 6 h into seven normal subjects with and without a replacement dose of glucagon. The addition of glucagon to somatostatin resulted in a 30-40% rise in plasma glucagon, whereas plasma insulin declined by 40-50% in both treatment groups. Plasma glucose and glucose production initially increased 2-fold with glucagon replacement, and subsequently declined by 2-3 h to levels comparable to those observed with somatostatin alone. After 6 h plasma glucose and glucose kinetics were no different whether or not glucagon was present. The rise in blood ketones after somatostatin was not exaggerated by glucagon replacement. We conclude that glucagon lack is not a modifying factor in the late hyperglycemic and hyperketonemic response to prolonged infusions of somatostatin.     

Influence of tyre inflation pressure on whole-body vibrations transmitted to the operator in a cut-to-length timber harvester

The influence of tyre inflation pressure on whole-body vibrations transmitted to the operator during the movement of a cut-to-length timber harvester was evaluated. Vibration measurements were taken in three orthogonal (x, y, z) axes at tyre pressure settings of 138, 345 and 414 kPa. Vibration was predominant in the vertical (z) direction with the peak rms acceleration value for the operator seat (0.281 ms(-2)) occurring at approximately 3.2 Hz.The corresponding peak value for the operator cabin chassis was 0.425 m s(-2) at 4 Hz.At 414 kPa, there was potential health risk on the operator for exposures above 8h duration. The vibration total values recorded for the operator seat at the maximum tyre inflation pressure setting were classed as "fairly uncomfortable" (ISO standard 2631-1), and vertical seat vibration transmissibility was highest between 4 and 8 Hz at the 345 kPa tyre pressure setting. The recorded values of WBV were significantly reduced by a reduction in tyre inflation pressure which may therefore be used to moderate the magnitude of WBV on wheeled timber harvesters.     

Effects of methyltestosterone on insulin secretion and sensitivity in women

The frequent coexistence of hyperandrogenism and insulin resistance is well established; however, whether a cause and effect relationship exists remains to be established. In this study we tested the hypothesis that short-term androgen administered to women would induce insulin resistance. To test this hypothesis, regularly menstruating, nonobese women were studied before and during methyltestosterone administration (5 mg tid for 10-12 days) by the hyperglycemic (n=8) and euglycemic, hyperinsulinemic (n=7) clamp techniques. Short-term methyltestosterone administration had no significant effects on the fasting levels of glucose, insulin, c-peptide, glucagon, or glucose turnover. During the hyperglycemic clamp studies, the mean glucose level during the final hour was 203+/-2 and 201+/-1 mg/dL in the methyltestosterone and control studies, respectively. The insulin response to this hyperglycemic challenge was slightly but not significantly greater during methyltestosterone treatment (first phase 59+/-8 vs. 50+/-8 microU/mL in controls; second phase 74+/-9 vs. 67+/-9 microU/mL in controls; total insulin response 133+/-16 vs. 117+/-15 microU/mL in controls). In spite of this, glucose uptake was reduced from the control study value of 10.96+/-1.11 to 7.3+/-0.70 mg/kg/min by methyltestosterone (P < 0.05). The ratio of glucose uptake per unit of insulin was also significantly reduced from a control study value of 14.3+/-1.4 to 9.4+/-1.3 mg/kg/min per microU/mL x 100 during methyltestosterone administration. In the euglycemic hyperinsulinemic clamp studies, insulin was infused at rates of 0.25 and 1.0 mU/kg/min to achieve insulin levels of approximately 25 and 68 microU/mL, respectively. During low-dose insulin infusion, rates of endogenous hepatic glucose production were equivalently suppressed from basal values of 2.37+/-0.29 and 2.40+/-0.27 mg/kg/min to 0.88+/-0.25 and 0.77+/-0.26 mg/kg/min in the methyltestesterone and control studies respectively. Whole body glucose uptake during low-dose insulin infusion was minimally affected. During the high-dose insulin infusion, endogenous hepatic glucose production was nearly totally suppressed in both groups. However, whole body glucose uptake was reduced from the control value of 6.11+/-0.49 mg/kg/min to 4.93+/-0.44 mg/kg/min during methyltestosterone administration (P < 0.05). Our data demonstrate that androgen excess leads to the development of insulin resistance during both hyperglycemic and euglycemic hyperinsulinemia. These findings provide direct evidence for a relationship between hyperandrogenemia and insulin resistance, and its associated risk factors for cardiovascular disease.     

Radiation therapy of giant aggressive keratoacanthomas

BACKGROUND AND DESIGN: Giant aggressive keratoacanthoma is a rare destructive subset of keratoacanthoma that frequently involves the facial region, grows rapidly to a large size, and often recurs after surgical management. The effectiveness of ionizing radiation therapy was examined in a retrospective study involving 16 patients; 14 of the tumors had recurred after surgical therapy. RESULTS: All tumors resolved with satisfactory cosmetic results and without recurrence following a fractionated course of superficial radiation therapy. CONCLUSIONS: Radiation therapy is an effective therapeutic modality for giant aggressive keratoacanthomas.     

Orthorhombic Materials and Perfect Lenses

The potential of orthorhombic materials for perfect lenses is theoretically examined.     

Computational haemodynamics: geometry and non-newtonian modelling using spectral/hp element methods

The increased availability of large scale computational facilities is enabling the use of computational modelling for the treatment of complex problems of industrial interest. Computational haemodynamics is an area where improved computational power and algorithmic development have permitted the application in biomechanics of techniques originally devised for direct numerical simulations in others areas of scientific interest. In this paper we present a highly accurate algorithm for the numerical solution of the incompressible Navier–Stokes equations which employs a spectral/hp element spatial discretisation and a high-order time splitting. Two important developments discussed in this paper are the coupling of these techniques with unstructured mesh generation, used in many everyday engineering applications, and the introduction of a non-Newtonian viscosity model to account for the shear thinning properties of blood. The proposed method will be applied to the analysis of shear stress distributions in flows of interest in haemodynamics. Received: 5 May 1999 / Accepted: 21 september 1999