Prospects of the use of beta-carotene enriched food products in the prevention and therapy of radiation injuries]

Radio-protective effectiveness of short-term (19 and 4 h before, 4 and 24 h after irradiation), long-term (3 times/week during 30 days after irradiation) and delayed (1 or 2 days after irradiation) enrichment with crystallized beta-carotene, in single doses of 0.1, 1.0 or 5.0 mg was evaluated in experimental acute external gamma-irradiation (0.029 Gy/sec) within the range of absorbed doses 9--6 Gy. The results obtained have permitted the authors to recommend the ration enriched with carotinoid for prevention and therapy of acute radiation injuries.     

Deep-MEG: spatiotemporal CNN features and multiband ensemble classification for predicting the early signs of Alzheimer’s disease with magnetoencephalography

Neural Computing and Applications - In this paper, we present the novel Deep-MEG approach in which image-based representations of magnetoencephalography (MEG) data are combined with ensemble...     

Delay and link utilization aware routing protocol for wireless multimedia sensor networks

Wireless Multimedia Sensor Networks (WMSNs) consist of networks of interconnected devices involved in retrieving multimedia content, such as, video, audio, acoustic, and scalar data, from the environment. The goal of these networks is optimized delivery of multimedia content based on quality of service (QoS) parameters, such as delay, jitter and distortion. In multimedia communications each packet has strict playout deadlines, thus late arriving packets and lost packets are treated equally. It is a challenging task to guarantee soft delay deadlines along with energy minimization, in resource constrained, high data rate WMSNs. Conventional layered approach does not provide optimal solution for guaranteeing soft delay deadlines due to the large amount of overhead involved at each layer. Cross layer approach is fast gaining popularity, due to its ability to exploit the interdependence between different layers, to guarantee QoS constraints like latency, distortion, reliability, throughput and error rate. The paper presents a channel utilization and delay aware routing (CUDAR) protocol for WMSNs. This protocol is based on a cross-layer approach, which provides soft end-to-end delay guarantees along with efficient utilization of resources. Extensive simulation analysis of CUDAR shows that it provides better delay guarantees than existing protocols and consequently reduces jitter and distortion in WMSN communication.     

The L467F-F508del Complex Allele Hampers Pharmacological Rescue of Mutant CFTR by Elexacaftor/Tezacaftor/Ivacaftor in Cystic Fibrosis Patients: The Value of the Ex Vivo Nasal Epithelial Model to Address Non-Responders to CFTR-Modulating Drugs

Loss-of-function mutations of the CFTR gene cause cystic fibrosis (CF) through a variety of molecular mechanisms involving altered expression, trafficking, and/or activity of the CFTR chloride channel. The most frequent mutation among CF patients, F508del, causes multiple defects that can be, however, overcome by a combination of three pharmacological agents that improve CFTR channel trafficking and gating, namely, elexacaftor, tezacaftor, and ivacaftor. This study was prompted by the evidence of two CF patients, compound heterozygous for F508del and a minimal function variant, who failed to obtain any beneficial effects following treatment with the triple drug combination. Functional studies on nasal epithelia generated in vitro from these patients confirmed the lack of response to pharmacological treatment. Molecular characterization highlighted the presence of an additional amino acid substitution, L467F, in cis with the F508del variant, demonstrating that both patients were carriers of a complex allele. Functional and biochemical assays in heterologous expression systems demonstrated that the double mutant L467F-F508del has a severely reduced activity, with negligible rescue by CFTR modulators. While further studies are needed to investigate the actual prevalence of the L467F-F508del allele, our results suggest that this complex allele should be taken into consideration as plausible cause in CF patients not responding to CFTR modulators.     

Binding Mode and Structure–Activity Relationships around Direct Inhibitors of the Nrf2–Keap1 Complex

An X‐ray crystal structure of Kelch‐like ECH‐associated protein (Keap1) co‐crystallised with (1S,2R)‐2‐[(1S)‐1‐[(1,3‐dioxo‐2,3‐dihydro‐1H‐isoindol‐2‐yl)methyl]‐1,2,3,4‐tetrahydroisoquinolin‐2‐carbonyl]cyclohexane‐1‐carboxylic acid (compound (S,R,S)‐ 1 a ) was obtained. This X‐ray crystal structure provides breakthrough experimental evidence for the true binding mode of the hit compound (S,R,S)‐ 1 a , as the ligand orientation was found to differ from that of the initial docking model, which was available at the start of the project. Crystallographic elucidation of this binding mode helped to focus and drive the drug design process more effectively and efficiently.     

Forecasting Home Sales in the Four Census Regions and the Aggregate US Economy Using Singular Spectrum Analysis

Accurate forecasts of home sales can provide valuable information for not only, policy makers, but also financial institutions and real estate professionals. Given this, our analysis compares the ability of two different versions of singular spectrum analysis (SSA) methods, namely recurrent SSA (RSSA) and vector SSA (VSSA), in univariate (UV) and multivariate (MV) frameworks, in forecasting seasonally unadjusted home sales for the aggregate US economy and its four census regions (Northeast, Midwest, South and West). We compare the performance of the SSA-based models with classical and Bayesian variants of the autoregressive (AR) and vector AR models. Using an out-of-sample period of 1979:8–2014:6, given an in-sample period of 1973:1–1979:7, we find that the UVVSSA is the best performing model for the aggregate US home sales, while the MV versions of the RSSA is the outright favorite in forecasting home sales for all the four census regions. Our results highlight the superiority of the nonparametric approach of the SSA, which in turn, allows us to handle any statistical process: linear or nonlinear, stationary or non-stationary, Gaussian or non-Gaussian.     

Tool-supported requirements prioritization: Comparing the AHP and CBRank methods

Requirements prioritization aims at identifying the most important requirements for a software system, a crucial step when planning for system releases and deciding which requirements to implement in each release. Several prioritization methods and supporting tools have been proposed so far. How to evaluate their properties, with the aim of supporting the selection of the most appropriate method for a specific project, is considered a relevant question.In this paper, we present an empirical study aiming at evaluating two state-of-the art tool-supported requirements prioritization methods, AHP and CBRank. We focus on three measures: the ease of use, the time-consumption and the accuracy. The experiment has been conducted with 23 experienced subjects on a set of 20 requirements from a real project. Results indicate that for the first two characteristics CBRank overcomes AHP, while for the accuracy AHP performs better than CBRank, even if the resulting ranks from the two methods are very similar. The majority of the users found CBRank the “overall best” method.     

Heterotopia of the mandibular third molar: a case report

A rare finding of unilateral heterotopia of a mandibular third molar was most probably caused by primary and total dislocation of the tooth base. Other possible causative factors, such as a lack of space between the mandibular second molar and the mandibular ramus or a disproportion between the base and the direction of growth of the third molar, have been considered in similar cases reported in the literature.