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排序方式: 共有86条查询结果,搜索用时 15 毫秒
1.
A Matsumori Y Matoba R Nishio T Shioi K Ono S Sasayama 《Canadian Metallurgical Quarterly》1996,222(3):678-682
We investigated hepatitis C virus (HCV) infection in 35 patients with hypertrophic cardiomyopathy and 40 patients with ischemic heart disease who were consecutively admitted to our hospital. Frequency of positive anti-HCV antibody was significantly higher in patients with hypertrophic cardiomyopathy (6 of 35 patients, 17.1%) than that in patients with ischemic heart disease (1 of 40 patients, 2.5%, p = 0.036). In three of these six patients with hypertrophic cardiomyopathy, HCV RNA was detected in myocardial tissue. In two of these three patients, HCV RNA was detected from biopsy and autopsy specimens of the ventricles, but not in the serum, suggesting that HCV may replicate in myocardial tissue and may be relevant to ventricular hypertrophy. Thus, HCV infection may play a role in the development of hypertrophic cardiomyopathy. 相似文献
2.
Tadayoshi Matsumori Tsuguo Kondoh Atsushi Kawamoto Tsuyoshi Nomura 《Structural and Multidisciplinary Optimization》2013,47(4):571-581
This paper deals with density-based topology optimization considering fluid and thermal interactions, in which the Navier–Stokes and heat transport equations are coupled. We particularly focus on designing heat exchangers. In the engineering context, heat exchangers are designed while considering a certain amount of input power. Therefore it is important to maximize the performance of a heat exchanger under a constant input power. In this paper we propose a way to control the input power by introducing an extra integral equation. To be more precise, in the fluid analysis, the inlet pressure is determined by solving the extra integral equation together with the Navier–Stokes equation. By doing this we can keep the inlet power constant even when the flow channels are changed in the optimization process. Consequently, the system of equations of the fluid field takes an integrodifferential form. On the other hand, in the heat transport analysis, a single governing equation is defined for simultaneously modeling both the solid and fluid parts. The design variable is a fluid fraction whose distribution represents the topology of the solid and fluid domains. When designing heat exchangers, two different heat conditions are considered in the formulation of the optimization problems, namely temperature-dependent and temperature-independent heat sources. Through the numerical examples for designing flow channels in a heat exchanger, it is shown that distinct topologies can be obtained according to the input power and the heat source conditions. 相似文献
3.
General topology optimization method with continuous and discrete orientation design using isoparametric projection 下载免费PDF全文
Tsuyoshi Nomura Ercan M. Dede Jaewook Lee Shintaro Yamasaki Tadayoshi Matsumori Atsushi Kawamoto Noboru Kikuchi 《International journal for numerical methods in engineering》2015,101(8):571-605
A general topology optimization method, which is capable of simultaneous design of density and orientation of anisotropic material, is proposed by introducing orientation design variables in addition to the density design variable. In this work, the Cartesian components of the orientation vector are utilized as the orientation design variables. The proposed method supports continuous orientation design, which is out of the scope of discrete material optimization approaches, as well as design using discrete angle sets. The advantage of this approach is that vector element representation is less likely to fail into local optima because it depends less on designs of former steps, especially compared with using the angle as a design variable (Continuous Fiber Angle Optimization) by providing a flexible path from one angle to another with relaxation of orientation design space. An additional advantage is that it is compatible with various projection or filtering methods such as sensitivity filters and density filters because it is free from unphysical bound or discontinuity such as the one at θ = 2π and θ = 0 seen with direct angle representation. One complication of Cartesian component representation is the point‐wise quadratic bound of the design variables; that is, each pair of element values has to reside in a given circular bound. To overcome this issue, we propose an isoparametric projection method, which transforms box bounds into circular bounds by a coordinate transformation with isoparametric shape functions without having the singular point that is seen at the origin with polar coordinate representation. A new topology optimization method is built by taking advantage of the aforementioned features and modern topology optimization techniques. Several numerical examples are provided to demonstrate its capability. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
4.
5.
This paper deals with an optimal part selection problem tominimize the expected cost, in an automated manufacturing system in which a flexible manufacturing cell produces different parts for several production lines. The optimal control problem is formulated as an undiscounted semi-Markov decision process. Properties of the optimal policy are analyzed. Moreover, sufficiency conditions are derived for the optimal policy to be of control iimit type. 相似文献
6.
Solar thermal applications require some means of thermal energy storage. Amongst several storage concepts, latent heat storage is quite suitable because of its high storage density and almost constant temperature during charging and discharging. The temperature range between 200 and 300°C is considered to be important for solar total energy systems. In this temperature range, sodium nitrate and its mixed salts with other nitrates including eutectic and off-eutectic salts are candidates.
The present paper deals with heat transfer in a latent heat storage unit utilizing these salts. A method of rough estimation of the thermal conductivity of the storage materials is described, and the temperature history of the storage material experimentally obtained is compared with numerical solutions and found to be in reasonably good agreement.
It is seen that the temperature of the heat transfer surface quickly drops soon after the appearance of a solid phase due to low thermal conductivity of these salts. Ways to avoid this temperature drop are discussed. 相似文献
7.
Decomposition of gaseous toluene and oxidation of CO on thermally excited titanium dioxide (TiO2)/silica (SiO2) composite material were investigated using a simple flow system. TiO2/SiO2 composite bead was superior to TiO2 (anatase) or TiO2/alumina in the thermally excited activation for toluene decomposition. The composite effect of TiO2/SiO2, bead was recognized in our study. ESR studies showed the existence of Ti3+ in the material. This means that oxygen vacancy would be generated by thermally excitation of TiO2 in the composite material. 相似文献
8.
R Nishio A Matsumori T Shioi W Wang T Yamada K Ono S Sasayama 《Canadian Metallurgical Quarterly》1998,32(3):808-815
OBJECTIVES: This study was designed to examine the effects of denopamine, a selective beta1-adrenergic agonist, in a murine model of congestive heart failure (CHF) due to viral myocarditis. BACKGROUND: Positive inotropic agents are used to treat severe heart failure due to myocarditis. However, sympathomimetic agents have not been found beneficial in animal models of myocarditis. METHODS: In vitro: The effects of denopamine on lipopolysaccharide-induced tumor necrosis factor-alpha (TNF-alpha) production was studied in murine spleen cells. In vivo: Four-week-old DBA/2 mice were inoculated with the encephalomyocarditis virus (day 0). Denopamine (14 micromol/kg), denopamine (14 micromol/kg) with a selective beta1-blocker metoprolol (42 micromol/kg), or denopamine (14 micromol/kg) with metoprolol (84 micromol/kg) was given daily, and control mice received the vehicle only. Survival and myocardial histology on day 14 and TNF-alpha levels in the heart on day 6 were examined. RESULTS: In the in vitro study, TNF-alpha levels in treated cells were significantly lower than in controls (p < 0.05). In the in vivo study treatment with denopamine significantly improved the survival of the animals (14 of 25 (56%) treated, vs 5 of 25 (20%) control mice), attenuated myocardial lesions, and suppressed TNF-alpha production (66.5+/-7.5 pg/mg of heart in treated mice vs 113.5+/-15.1 pg/mg of heart in control mice, mean+/-SE). There was a strong linear relationship between mortality and TNF-alpha levels (r=0.98, n=4, p < 0.05). These in vitro and in vivo effects of denopamine were significantly inhibited by metoprolol. CONCLUSIONS: These results suggest that denopamine may exert its beneficial effects, in part, by suppressing the production of TNF-alpha via beta1-adrenoceptors. 相似文献
9.
In this study the behaviour of the small displacement of starting rolling friction in the rolling contact between a flat surface and rollers is investigated and a rolling friction force-displacement relationship in the region of the starting rolling displacement is proposed by using the fact that the area of the hysteresis loop increases linearly with the nth power of the rolling friction.Furthermore, the behaviour of the hysteresis loop at the rolling contact surface has been investigated experimentally and theoretically. It was found that the area of the hysteresis loop increases linearly with the second power of the rolling distance in the region of a starting rolling displacement. 相似文献
10.
Okabayashi A Wakai S Kanao T Sugio T Kamimura K 《Journal of Bioscience and Bioengineering》2005,100(6):644-652
Four acidophilic bacteria (YARDs1-4) were isolated from an acid rock drainage (ARD) from Yanahara mine, Okayama prefecture, Japan. The physiological and 16S rDNA sequence analyses revealed that YARD1 was closely affiliated with Acidithiobacillus ferrooxidans, YARD2 was an Acidiphilium-like bacterium, and YARD3 and YARD4 were sulfur-oxidizing bacteria with a relatively close relationship to A. ferrooxidans in the phylogenetic analysis. A molecular approach based on the construction of a 16S rDNA clone library was used to investigate the microbial population of the ARD. Small-subunit rRNA genes were PCR amplified, subsequently cloned and screened for variation by a restriction fragment length polymorphism (RFLP) analysis. A total of 284 clones were grouped into 133 operational taxonomic units (OTUs) by the RFLP analysis. Among them, an OTU showing the same RFLP pattern as those of the isolates from the ARD was not detected. The phylogenetic analysis based on the 16S rDNA sequences from 10 major OTUs and their close relatives revealed that 4 OTUs containing 32.1% of the total clones were loosely affiliated with Verrucomicrobia, 2 OTUs containing 6.6% of the total clones were loosely affiliated with Chloribi, and other OTUs were affiliated with Actinobacteria, Nitrospirae, and beta-Proteobacteria. 相似文献