Scale‐up and Spouting of Two‐Dimensional Beds

The objective of this paper is to present an analysis on the scale‐up procedure of two‐dimensional spouted beds. The task was carried out with three different beds measuring 0.15, 0.30 and 0.80 in width. The conditions of scale‐up were studied through geometrical similitude analysis. Some parameters of scale were adimensionalised, tested and validated in order to propose relationships capable of predicting values of dependent properties. Those relationships should be followed in a prototype of an equipment of industrial scale. The study permitted the development of correlations to predict values of maximum pressure drop, minimum spout velocity and maximum height of spouting.     

Determination of polyphosphates in products of animal origin: application of a validated ion chromatography method for commercial samples analyses

A reliable and accurate analytical method was developed and validated for the quantitative determination of polyphosphates (diphosphate, triphosphate, trimetaphosphate and tetrapolyphosphate) in products of animal origin (meat, dairy and fish products) by ion chromatography with suppressed conductivity detection. The chromatographic separations were accomplished by using an anion-exchange column eluted with a sodium hydroxide gradient. The method validation, performed according to Regulation 882/2004/EC and Decision 657/2002/EC, provided results conform with the European Directives with respect to linearity (R?>?0.996), specificity, precision (CV????4.5?%), recovery (ranging from 87.2 to 101.1?%), detection and quantification limits and ruggedness. The method reliability was confirmed evaluating the method measurement uncertainty, lower than 7.5?% and by proficiency test results. Finally, the method ability to discriminate samples treated from those not-treated with polyphosphates was verified by analyzing commercial samples containing polyphosphates (cooked ham, wurstel, corned beef, processed cheese and surimi) or treated in-house with polyphosphates (pangasius fillets, shrimps and cuttlefishes).     

Cottonseed protein food products

Upward trending world population and increasing costs for traditional food proteins provide many incentives for utilization of oilseed proteins directly in human diets. Cotton, as one of the world's major oilseed crops, represents a potential source of food protein. Acceptability of oilseed protein products in terms of functional properties in food systems and nutritional value will largely determine the extent of their utilization by the food industry. Liquid cyclone process cottonseed flour, defatted glandless cottonseed flour, storage protein isolates, and cottonseed whey proteins have been evaluated by various functionality tests and in a number of food systems. The cottonseed flours have been subjected to processing by extrusion texturization. Human feeding studies have also been conducted. Results indicate a good potential for use of cottonseed protein products in a variety of food systems.     

A comparison of classical, robust, and decentralized controldesigns for multiple power system stabilizers

Several control design techniques, namely, the classical phase compensation approach, the μ-synthesis, and a linear matrix inequality technique, are used to coordinate two power system stabilizers to stabilize a 5-machine equivalent of the South/Southeast Brazilian system. The open-loop system has an unstable intearea mode and cannot be stabilized using only one conventional power system stabilizer. Both centralized and decentralized controllers are considered. The different designs are compared and several interesting observations are provided     

Are child occupants a significant source of driving distraction?

Driver distraction represents a well-documented and growing contribution to the road safety problem. This study used a naturalistic, observational approach to examine if children in vehicles are a significant source of driving distraction. Families with children aged between 1 and 8 years drove an instrumented “study vehicle” on their regular trips for 3 weeks. A discrete video recording system in the vehicle provided images of the driver and front seat passenger, the rear seat child passengers and the traffic ahead. The video-recordings inside and outside the vehicle were analysed to identify potential distracting activities, where ‘distraction’ was broadly defined as any activity that distracted the driver or competed for their attention while driving. In addition, all potentially distracting activities that involved the driver looking away from the forward roadway for more than 2 s while the vehicle was in motion were also coded. Video-recordings were analysed for 92 driving journeys undertaken by 12 families including 25 children and 19 drivers. The mean journey duration was approximately 16 min (range: 2 min–3 h 34 min). Most journeys were undertaken during the day (89%), with the mother driving (65%) and without a front seat passenger (64%). Driving journeys were predominantly undertaken in urban areas (97%), on suburban roads/streets (94%), and under low complexity traffic conditions (91%). Most journeys involved some source of potential driver distraction (98%), with drivers distracted for 18% of the driving journey. The most frequent types of distracting activities that drivers engaged in included: touching their head or their face (35%), interacting with child passengers in the rear seat (12%), and engaging with the front seat passenger (9%). Almost three-quarters of these potentially distracting activities were engaged in by the driver while the study vehicle was in motion (72%) and 14% of all potentially distracting activities involved the driver's eyes off the roadway for greater than 2 s while the vehicle was in motion, thereby potentially doubling their crash risk. The most frequent child-related activities that drivers engaged in included: turning to look at the rear seated occupants or viewing the children using the rear-view mirror (76.4%), engaging in conversation with their children (16%), assisting their children (e.g., passing food and drink [7%]) and playing with their children (1%). Drivers spent significantly longer periods of time engaged in non-child occupant-related activities compared with child occupant-related activities and were significantly more likely to have their eyes off the forward roadway for greater than 2 s while engaged in non-child occupant-related activities (14%) compared to child occupant-related activities (10%). The results suggest that drivers need to be educated about the potential crash and injury risks associated with both child occupant-related and non-child occupant-related activities while driving their vehicle.     

Application of thin film head technology to a high performance head/track disk file

Processing technologies and performance parameters of thin film recording heads used in a 6.7Mbyte disk memory are presented. Photolithographic, vacuum deposition, and ceramic substrate fabrication procedures are described for a single turn, multi-track head assembly. Interlayer diffusion and thermal heating are described. Data relating spacing loss, bit density, gap geometry, and write currents to signal amplitude and timing are given for NiCo media. Special cables and integrated write/read IC's are described.     

Tricuspid regurgitation and acute myocardial infarction

A 71-year-old man had a right ventricular infarct complicated with hypotension and transient complete atrioventricular block. The patient was found to have tricuspid regurgitation, which was corrected with a prosthetic tricuspid valve. After correction, there was dramatic improvement in his clinical status, with correction of persistent hypotension and weakness and early discharge home to full activity. Tricuspid regurgitation is a mechanical defect of acute myocardial infarction that benefits greatly from surgical correction. This therapy should be considered in any individual in whom tricuspid regurgitation complicates acute right ventricular infarction.     

Inhibition of the FGF/FGFR System Induces Apoptosis in Lung Cancer Cells via c-Myc Downregulation and Oxidative Stress

Lung cancer represents an extremely diffused neoplastic disorder with different histological/molecular features. Among the different lung tumors, non-small-cell lung cancer (NSCLC) is the most represented histotype, characterized by various molecular markers, including the expression/overexpression of the fibroblast growth factor receptor-1 (FGFR1). Thus, FGF/FGFR blockade by tyrosine kinase inhibitors (TKi) or FGF-ligand inhibitors may represent a promising therapeutic approach in lung cancers. In this study we demonstrate the potential therapeutic benefit of targeting the FGF/FGFR system in FGF-dependent lung tumor cells using FGF trapping (NSC12) or TKi (erdafitinib) approaches. The results show that inhibition of FGF/FGFR by NSC12 or erdafitinib induces apoptosis in FGF-dependent human squamous cell carcinoma NCI-H1581 and NCI-H520 cells. Induction of oxidative stress is the main mechanism responsible for the therapeutic/pro-apoptotic effect exerted by both NSC12 and erdafitinib, with apoptosis being abolished by antioxidant treatments. Finally, reduction of c-Myc protein levels appears to strictly determine the onset of oxidative stress and the therapeutic response to FGF/FGFR inhibition, indicating c-Myc as a key downstream effector of FGF/FGFR signaling in FGF-dependent lung cancers.     

Design and Analysis of New Micromixers Based on Distillation Column Trays

Four passive micromixer designs (G1, G2, G3, and G4) based on distillation columns trays are proposed. The performance of the devices is assessed by numerical simulations. The mixing performance is investigated for different Reynolds numbers and channel heights for oil/ethanol flow. G1 and G4 designs provided a high mixing index. The G1 device achieved superior mixing performance with a moderate pressure drop due to the induced flow recirculation pattern for a relatively high flow rate, highlighting the potential use of such microdevice for scale-up and numbering-up of microdevices in modular chemical plant processing.     

3D printed millireactors for process intensification

The scope of the present research aims at demonstrating the 3D printing use in the manufacturing of microchannels for chemical process applications. A comparison among digital model processing applications for 3D print(slicers) and a print layer thickness analysis were performed. The 3D print fidelity was verified in several devices, including the microchannels' printing with and without micromixer zones. In order to highlight the 3D print potential in Chemical Engineering, the biodiesel synthesis was also carried out in a millireactor manufactured by 3D printing. The millireactor operated under laminar flow regime with a total flow rate of 75.25 ml ? min~(-1)(increment of about 130 times over traditional microdevices used for biodiesel production).The printed millireactor provided a maximum yield of Ethyl Esters of 73.51% at 40 °C, ethanol:oil molar ratio of7 and catalyst concentration of 1.25 wt% and residence time about 10 s. As a result of flow rate increment attained in the millireactor, the number of required units for scaling-up the chemical processes is reduced. Using the approach described in the present research, anyone could produce their own millireactor for chemical process in a simple way with the aid of a 3D printer.