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1.
Hanna Pietil inen Tarja Saesmaa Veli-Pekka Tanninen 《Drug development and industrial pharmacy》1996,22(11):1063-1073
In order to investigate the formation of organic salts of drugs, two salts of pindolol were prepared using salt-forming agents which were crystalline and suitable for physical studies in the solid state. The stoichiometry of the products, pindolol benzoate and pindolol 2-methoxyphenylacetate, was established by elemental analysis. The precipitates formed were assessed by differential scanning calorimetry (DSC), thermogravimetry (TG), x-ray powder diffractometry (XRPD) and Fourier transform-infrared spectrometry (FT-IR). According to the TG and DSC curves, there was no water of crystallization in the precipitates, and the products were thermally stable. Both precipitates gave one sharp melting endotherm which differed from the endotherms of the starting compounds. The x-ray dipaction pattern of the precipitates direred clearly from those of the starting materials, acid and base. The products showed absorption by FT-IR typical of carboxylic acid salts at about 1640-1540 cm-1. The carbonyl absorption indicative of the carboxylic acid group of benzoic acid or 2-methonyphenylacetic acid was not detectable in the spectra of the precipitates. All this indicates that two new crystalline organic salts (1:1) were formed during the syntheses. 相似文献
2.
Annalisa Bernareggi Alessandra Bosutti Gabriele Massaria Rashid Giniatullin Tarja Malm Marina Sciancalepore Paola Lorenzon 《International journal of molecular sciences》2022,23(12)
Piezo1 channels are highly mechanically-activated cation channels that can sense and transduce the mechanical stimuli into physiological signals in different tissues including skeletal muscle. In this focused review, we summarize the emerging evidence of Piezo1 channel-mediated effects in the physiology of skeletal muscle, with a particular focus on the role of Piezo1 in controlling myogenic precursor activity and skeletal muscle regeneration and vascularization. The disclosed effects reported by pharmacological activation of Piezo1 channels with the selective agonist Yoda1 indicate a potential impact of Piezo1 channel activity in skeletal muscle regeneration, which is disrupted in various muscular pathological states. All findings reported so far agree with the idea that Piezo1 channels represent a novel, powerful molecular target to develop new therapeutic strategies for preventing or ameliorating skeletal muscle disorders characterized by an impairment of tissue regenerative potential. 相似文献
3.
Pietarinen Tarja Palonen Tuire Vauras Marja 《International Journal of Computer-Supported Collaborative Learning》2021,16(2):261-287
International Journal of Computer-Supported Collaborative Learning - Technology-enhanced collaborative inquiry learning has gained a firm position in curricula across disciplines and educational... 相似文献
4.
Heponiemi Tarja; Kouvonen Anne; V?nsk? Jukka; Halila Hannu; Sinervo Timo; Kivim?ki Mika; Elovainio Marko 《Canadian Metallurgical Quarterly》2009,14(4):365
The present study examined whether job control moderated the association between stress indicators (distress and sleeping problems) and intentions to change profession among 2,650 Finnish physicians. Ordinal logistic regression analysis was applied. The authors found that high levels of distress and sleeping problems were associated with higher levels of intentions to change profession, whereas high job control was associated with lower levels of intentions to change profession even after adjusting for the effects of gender, age, and employment sector. In addition, high job control was able to mitigate the positive association that distress and sleeping problems had with intentions to change profession. Our findings highlight the importance of offering more job control to physicians to prevent unnecessary physician turnover. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
5.
The use of building information modelling (BIM) and related software tools is increasingly expanding in the work of site managers in construction projects. The early uses of BIM in the actual tasks of site managers are explored by examining the utilization of BIM in their work and the challenges in the deployment of the new digital tools for traditional project collaboration. The ethnographic method of the study consists of shadowing the site managers’ work. The site managers actively used BIM and found it beneficial for their daily work. However, the use of BIM in construction sites is still limited because only a few managers have the competence to use BIM software tools, mobile tools are lacking, and the information content of the models needed for construction work is insufficient. 相似文献
6.
A study was conducted at Lake J?ms?nvesi in Central Finland, to identify the potential ecotoxicological risks of the remediation operation of a creosote-/PAH-contaminated lake sediment, made by capping during the years 1998-1999. Mussels (Anodonta anatina) were deployed to the lake at the same time as the remediation operation was started in November 1998. The contaminated area (0.5 ha) was covered by a filter geotextile (polypropylene), gravel and sand (1-1.5m) which were spread out on the ice and let to sink onto the bottom of the lake when the ice melted in May 1999. The possible impacts of capping to the adjacent environment were assessed from mussels exposed and particulate material settled (SPM) to collectors placed on the lake bottom. Mussel tissue, SPM, the water inside the collector were analyzed for polycyclic aromatic compounds (PAH)-compounds. Biological endpoints included body condition, glycogen and protein contents of adductor muscle. Mussels and SPM exposed downstream to the contaminated site (Site 3) contained the highest total PAH concentrations. Biota-sediment accumulation factors of acenaphthene, phenanthrene, anthracene, fluoranthene, pyrene and benzo(a)anthracene of mussels varied from 0.79 to 1.45. The glycogen and protein concentrations were lowest in adductor muscle from mussels exposed to conditions at Site 3. Concentrations of some PAH-compounds were found distinctly increased adjacent to the remediated area, possibly due to the agitation of contaminated sediment due to the capping. It is also possible that resuspension of sediment around remediated area (containing some PAHs) spread the deposited PAH-compounds. 相似文献
7.
Paolo Tonella Marco Torchiano Bart Du Bois Tarja Systä 《Empirical Software Engineering》2007,12(5):551-571
Starting with the aim of modernizing legacy systems, often written in old programming languages, reverse engineering has extended its applicability to virtually every kind of software system. Moreover, the methods originally designed to recover a diagrammatic, high-level view of the target system have been extended to address several other problems faced by programmers when they need to understand and modify existing software. The authors’ position is that the next stage of development for this discipline will necessarily be based on empirical evaluation of methods. In fact, this evaluation is required to gain knowledge about the actual effects of applying a given approach, as well as to convince the end users of the positive cost–benefit trade offs. The contribution of this paper to the state of the art is a roadmap for the future research in the field, which includes: clarifying the scope of investigation, defining a reference taxonomy, and adopting a common framework for the execution of the experiments. 相似文献
8.
Dr. Tarja Kokkola Dr. Tiina Suuronen Dr. Maija Pesonen Prof. Panagis Filippakopoulos Dr. Antero Salminen Dr. Elina M. Jarho Dr. Maija Lahtela‐Kakkonen 《Chembiochem : a European journal of chemical biology》2015,16(14):1997-2001
Control of histone acetylation is a part of the epigenetic mechanism that regulates gene expression and chromatin architecture. The members of the bromodomain and extra terminal domain (BET) protein family are a group of epigenetic readers that recognize histone acetylation, whereas histone deacetyl‐ ases such as sirtuin 1 (SIRT1) function as epigenetic erasers. We observed that BET inhibition by the specific inhibitor JQ1 upregulated SIRT1 expression and activated SIRT1. Moreover, we observed that BET inhibition functionally reversed the pro‐inflammatory effect of SIRT1 inhibition in a cellular lung disease model. SIRT1 activation is desirable in many age‐related, metabolic and inflammatory diseases; our results suggest that BET protein inhibition would be beneficial in treatment of those conditions. Most importantly, our findings demonstrate a novel mechanism of SIRT1 activation by inhibition of the BET proteins. 相似文献
9.
Volatile compounds of Baltic herring analysed by dynamic headspace sampling–gas chromatography–mass spectrometry 总被引:1,自引:1,他引:1
Aro Tarja Tahvonen Raija Koskinen Lotta Kallio Heikki 《European Food Research and Technology》2003,216(6):483-488
European Food Research and Technology - The effect of storage time at 6&;nbsp;°C on the volatile compounds of Baltic herring was studied using the dynamic headspace–gas... 相似文献
10.
Tarja Kuosa 《AI & Society》1999,13(1-2):176-192
In this article we look at the conceptions computing professionals have of the future. We studied these conceptions by analysing 31 essays on the future published in theCommunications of the ACM. We found the future was envisioned from three different perspectives: in addition to a technology centred perspective the authors also used human centred and society centred perspectives, but region centred and organisation centred perspectives were missing. I assume the visions of these individuals of future technology represent the culture of the computing field as they are published in one of the top computer science journals. 相似文献