Alpha blockaders--first or second line antihypertensive agents?

Alpha-receptor blockers reduce blood pressure by blocking of the alpha 1-receptors in the smooth muscle cells in the arteriolar walls. The heart pump function is not disturbed. Most studies have shown that the alpha-receptor blockers induce a reduction in plasma-triglycerides and an increase in the ratio between HDL- and LDL-cholesterol. They do not interfere with the metabolism of electrolytes, glucose or uric acid and have no negative effect on pulmonary function. Although long-term use does not induce a permanent increase in heart rate, some patients respond to initial therapy with faster heart rate and palpitations. The alpha-receptor blockers should not be used in patients with coronary heart disease if the patient is not on chronic beta-blockade. When these precautions are followed, the alpha-blockers can be used as first-line treatment--just like ACE-inhibitors and calcium-antagonists.     

A comparison among 1-, 3-, and 7-horn feeds for a 37-beam MBA

A very common multiple beam antenna (MBA) configuration consists of a collimating device illuminated by an array of feeds. The collimating device is usually a reflector or a lens. The feeds are usually horn antennas with a circular aperture. The reflector is usually offset-fed to eliminate aperture blockage; the lens is center fed. The antenna's feeds are excited to produce a finite number of beams, so as to provide contiguous coverage of the field of view. The designer is forced to minimize the angular spacing between adjacent beams in order to maximize the minimum gain over the antenna's field of view. On the other hand, the feed horn's aperture gain is maximized when the feed horn spacing and its aperture diameter are equal. This results in antenna efficiency of the order of 30% when a single feed horn is excited to produce a beam. When a cluster of 3 or 7 adjacent feed horns are excited to produce a single beam, antenna efficiency can be increased to 50%. When it is tolerable, several identical antenna apertures can be used to replace a single aperture configuration. In this case, each of M apertures produces approximately N/M beams of an MBA that produces N beams. Horns producing adjacent beams do not illuminate the same aperture. This permits the use of a much larger horn aperture for a given beam spacing. This results in reduced spillover, higher gain of each beam, and increased antenna efficiency of each aperture. This paper investigates the maximization of gain for several lens antennas. It shows that antenna gain is increased as its focal length is decreased. That is, a focal length-to-diameter ratio (F/D) less than 1 is preferred     

Activation of auditory cortex during silent lipreading

Watching a speaker's lips during face-to-face conversation (lipreading) markedly improves speech perception, particularly in noisy conditions. With functional magnetic resonance imaging it was found that these linguistic visual cues are sufficient to activate auditory cortex in normal hearing individuals in the absence of auditory speech sounds. Two further experiments suggest that these auditory cortical areas are not engaged when an individual is viewing nonlinguistic facial movements but appear to be activated by silent meaningless speechlike movements (pseudospeech). This supports psycholinguistic evidence that seen speech influences the perception of heard speech at a prelexical stage.     

Non-smoking policies and practices in Norwegian delivery units in 1994

OBJECTIVE: To determine the number of delivery units in Norway that have become smoke free for employees and patients. DESIGN: A pre- categorised questionnaire was sent in September 1994 to the physician or midwife responsible for each of the 68 delivery units in the country. MAIN OUTCOME MEASURES: Hospital smoking policies, reported difficulties in implementation, use of nicotine replacement therapy in patients, and provision of information on tobacco-related health hazards to patients. RESULTS: Fifty-six units (82.3%), accounting for 93% of all deliveries in Norway in 1993, responded. Of these, 42 (75%) were smoke-free for employees, and 33 (59%) for patients. Nearly all had become smoke-free after 1990. No significant difference was seen according to type or size of delivery unit. No difficulties in the implementation of policies restricting smoking were reported. Thirty- one (55%) routinely informed patients of the health implications of smoking during pregnancy. Two units offered nicotine replacement therapy to patients. CONCLUSION: Most Norwegian delivery units were smoke-free for both employees and patients. Provided that the recent trend toward adoption of smoke-free policies continues, all delivery units in Norway should be smoke-free by 1997-1998.




     

The stability and unfolding of an IgG binding protein based upon the B domain of protein A from Staphylococcus aureus probed by tryptophan substitution and fluorescence spectroscopy

The stability and unfolding of an immunoglobulin (Ig) G bindingprotein based upon the B domain of protein A (SpAB) from Staphylococcusaureus were studied by substituting tryptophan residues at strategiclocations within each of the three a-helical regions (al-a3)of the domain. The role of the C-terminal helix, a3, was investigatedby generating two protein constructs, one corresponding to thecomplete SpAB, the other lacking a part of ct3; the Trp substitutionswere made in both one-and two-domain versions of each of theseconstructs. The fluorescence properties of each of the single-tryptophanmutants were studied in the native state and as a function ofguanidine-HCl-mediated unfolding, and their IgG binding activitieswere determined by a competitive enzyme-linked immunosorbentassay. The free energies of folding and of binding to IgG foreach mutant were compared with those for the native domains.The effect of each substitution upon the overall structure andupon the IgG binding interface was modelled by molecular graphicsand energy minimization. These studies indicate that (i) 3 contributesto the overall stability of the domain and to the formationof the IgG binding site in l and 2, and (ii) al unfolds first,followed by 2 and 3 together.     

Robustness of ISS systems to inputs with limited moving average: Application to spacecraft formations

We provide a theoretical framework that fits realistic challenges related to spacecraft formation with disturbances. We show that the input‐to‐state stability of such systems guarantees some robustness with respect to a class of signals with bounded average‐energy, which encompasses the typical disturbances acting on spacecraft formations. Solutions are shown to converge to the desired formation, up to an offset, which is somewhat proportional to the considered moving average of disturbances. In the presence of fast peaking perturbations, the approach provides a tighter evaluation of the disturbances' influence, which allows for the use of more parsimonious control gains. Copyright © 2015 John Wiley & Sons, Ltd.     

Suspension system performance optimization with discrete design variables

Suspension systems on commercial vehicles have become an important feature meeting the requirements from costumers and legislation. The performance of the suspension system is often limited by available catalogue components. Additionally the suspension performance is restricted by the travel speed which highly influences the ride comfort. In this article a suspension system for an articulated dump truck is optimized in sense of reducing elapsed time for two specified duty cycles without violating a certain comfort threshold level. The comfort threshold level is here defined as a whole-body vibration level calculated by ISO 2631-1. A three-dimensional multibody dynamics simulation model is applied to evaluate the suspension performance. A non-gradient optimization routine is used to find the best possible combination of continuous and discrete design variables including the optimum operational speed without violating a set of side constraints. The result shows that the comfort level converges to the comfort threshold level. Thus it is shown that the operational speed and hence the operator input influences the ride comfort level. Three catalogue components are identified by the optimization routine together with a set of continuous design variables and two operational speeds one for each load case. Thus the work demonstrates handling of human factors in optimization of a mechanical system with discrete and continuous design variables.     

Learning traversability models for autonomous mobile vehicles

Autonomous mobile robots need to adapt their behavior to the terrain over which they drive, and to predict the traversability of the terrain so that they can effectively plan their paths. Such robots usually make use of a set of sensors to investigate the terrain around them and build up an internal representation that enables them to navigate. This paper addresses the question of how to use sensor data to learn properties of the environment and use this knowledge to predict which regions of the environment are traversable. The approach makes use of sensed information from range sensors (stereo or ladar), color cameras, and the vehicle’s navigation sensors. Models of terrain regions are learned from subsets of pixels that are selected by projection into a local occupancy grid. The models include color and texture as well as traversability information obtained from an analysis of the range data associated with the pixels. The models are learned without supervision, deriving their properties from the geometry and the appearance of the scene. The models are used to classify color images and assign traversability costs to regions. The classification does not use the range or position information, but only color images. Traversability determined during the model-building phase is stored in the models. This enables classification of regions beyond the range of stereo or ladar using the information in the color images. The paper describes how the models are constructed and maintained, how they are used to classify image regions, and how the system adapts to changing environments. Examples are shown from the implementation of this algorithm in the DARPA Learning Applied to Ground Robots (LAGR) program, and an evaluation of the algorithm against human-provided ground truth is presented.

A new document representation using term frequency and vectorized graph connectionists with application to document retrieval

This paper presents a new document representation with vectorized multiple features including term frequency and term-connection-frequency. A document is represented by undirected and directed graph, respectively. Then terms and vectorized graph connectionists are extracted from the graphs by employing several feature extraction methods. This hybrid document feature representation more accurately reflects the underlying semantics that are difficult to achieve from the currently used term histograms, and it facilitates the matching of complex graph. In application level, we develop a document retrieval system based on self-organizing map (SOM) to speed up the retrieval process. We perform extensive experimental verification, and the results suggest that the proposed method is computationally efficient and accurate for document retrieval.