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排序方式: 共有87条查询结果,搜索用时 15 毫秒
1.
Avishek Sarbajna Andres Georg Rösch Leonard Franke Uli Lemmer Md Mofasser Mallick 《Advanced Engineering Materials》2023,25(2):2200980
One of the simplest ways to generate electric power from waste heat is thermoelectric (TE) energy conversion. So far, most of the research on thermoelectrics has focused on inorganic bulk TE materials and their device applications. However, high production costs per power output and limited shape conformity hinder applications of state-of-the-art thermoelectric devices (TEDs). In recent years, printed thermoelectrics has emerged as an exciting pathway for their potential in the production of low-cost shape-conformable TEDs. Although several inorganic bulk TE materials with high performance are successfully developed, achieving high performance in inorganic-based printed TE materials is still a challenge. Nevertheless, significant progress has been made in printed thermoelectrics in recent years. In this review article, it is started with an introduction signifying the importance of printed thermoelectrics followed by a discussion of theoretical concepts of thermoelectricity, from fundamental transport phenomena to device efficiency. Afterward, the general process of inorganic TE ink formulation is summarized, and the current development of the inorganic and hybrid inks with the mention of their TE properties and their influencing factors is elaborated. In the end, TEDs with different architecture and geometries are highlighted by documenting their performance and fabrication techniques. 相似文献
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CYTOCENTERING: a novel technique enabling automated cell-by-cell patch clamping with the CYTOPATCH chip 总被引:4,自引:0,他引:4
Automats for patch clamping suspended cells in whole-cell configuration must (1) bring isolated cells in contact with patch contacts, (2) form gigaseals, and (3) establish stable intracellular access that allows for high quality recording of ionic currents. Single openings in planar substrates seem to be intriguing simple solutions for these problems, but due to the low rate of formation of whole-cell configurations we discarded this approach. Single openings are not suited for both attracting cells to the opening by suction and forming gigaseals with subsequent membrane rupture. To settle the three tasks with a mechanical microstructure we developed the socalled CYTOCENTERING technique to apply to suspended cells the same operation sequence as in conventional patch clamping. With this method we immobilized selected cells from a flowing suspension on the tip of a patch pipette by suction with a success rate of 97% and formed gigaseals with a success rate of 68%. Subsequent whole-cell recordings and intracellular staining with Lucifer yellow proved the stable access to the cytoplasm. Currently, a chip with an embedded suction opening in glass surrounding the microstructured contact pipette is under development. The processing of this CYTOPATCH chip is compatible to large-volume production. The CYTOPATCH automat will allow for fully automated, parallel, and asynchronous whole-cell recordings. 相似文献
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It is shown that a Markovian queue, with bulk arrivals and departures having any probability mass functions for their batch sizes, has geometrically distributed queue length at equilibrium (when this exists) provided there is an additional special bulk arrival stream, with particular rate and batch size distribution, when the server is idle. It is shown that the time-averaged input rate of the special arrivals tends to zero as the queue becomes saturated, and a heavy-traffic limit for the queue without special arrivals is derived by martingale methods. This is shown to give the same asymptotic queue length probabilities as the geometric model. The product form is then extended to tandem networks of batch queues using the reversed compound agent theorem (RCAT). In order to obtain the product form in this case, it is required that, in addition to special arrival streams, so-called ‘partial batches’ are discarded immediately from the network when there are not enough customers in the queue to fill an entire departing batch. Somewhat surprisingly it turns out that, in heavy traffic, the product-form network does not always agree with the regulated Brownian motion (RBM) diffusion limit for the standard network without special arrivals and where partial batches are not discarded, but forwarded to the next node. Indeed, we show that the two models agree in heavy traffic if and only if the skew-symmetry condition for the RBM to have a product form is satisfied. When the condition does hold, our theoretical and numerical results thus validate the use of the product-form batch networks as moderate-traffic approximations to the analogous standard queueing network model without special arrivals and where partial batches may be forwarded to the next node instead of being lost. In the case that the condition does not hold, we obtain a new product-form stationary distribution for the associated non-RBM diffusion limit. 相似文献
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Schmidt Uli; Rudolph Rainer; Bohm Gerald 《Protein engineering, design & selection : PEDS》2001,14(10):769-774
The development of novel delivery systems for therapeutic substancesincludes targeting of the carriers to a specific site or tissuewithin the body of the recipient. This can be accomplished byappropriate receptor-binding domains and requires linking ofthese domains to the carrier. We have used recombinantly expressedpolyomavirus-like particles as a model system and inserted thesequence of a WW domain into different surface loops of theviral capsid protein VP1. In one variant, the WW domain maintainedits highly selective binding properties of proline-rich ligandsand showed an increased affinity but also an accelerated association/dissociationequilibrium compared to the isolated WW domain, thus allowinga short-term coupling of external ligands onto the surface ofthe virus-like particles. 相似文献
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Ulf Jenk Udo Zimmermann Uli Uhlig Ralph Schöpke Michael Paul 《Mine Water and the Environment》2014,33(1):39-47
Within the WISMUT environmental remediation programme, the rehabilitation of the former uranium mine at Königstein is a very special case due to its use of underground leaching and its location near the Elbe River. The mine water is acidic, oxidizing, and polluted with uranium and other contaminants, and must be pumped to the surface and treated. In-situ water treatment approaches have been investigated to optimise further flooding and shorten the period of conventional water treatment. In 2010/2011, a field-scale experiment was carried out: about 120 t of alkalinity were successfully injected into the partially flooded mine. Tracer signals and geochemical reactions achieved general expectations. Based on the results, a site-specific technology concept was developed to flood the mine to its natural decant level. 相似文献
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