Towards hybrid Triple Helix indicators: A study of university-related patents and a survey of academic inventors

This paper presents work directed at capturing the entrepreneurial and collaborative activity of university researchers. The Triple Helix points to the emergence of the entrepreneurial university as well as to an increasing overlay of activities in universities, industry and government. This study explores ways in which patent-based metrics could be utilized in a Triple Helix context, and how hybrid indicators could be developed by combining patent with survey data. More specifically, it aims to develop indicators that connect technological inventiveness of university researchers to both funding organizations and users, as well as to entrepreneurial activities by academics. The paper develops a simplified model of the innovation process to benchmark the relevance of the indicators to the Triple Helix. An analysis of Finnish academic patents illustrates that patent data can already provide useful indicators but, on its own, cannot provide information about how academic patents are interconnected with government or industry through funding or utilization links. An exclusive analysis of patents can point to patent concentrations on certain universities, to inventors and assignees, or to potential gaps in translating applied science into industrial technology. However, the patent data had to be combined with an inventor survey in order to relate academic patents more to their Triple Helix environment. The survey indicated that most patented academic inventions are connected to (often publicly funded) scientific research by the inventors and tend to be utilized in large firms rather than in start-up companies founded by academic entrepreneurs.     

Inventive output of academic research: A comparison of two science systems

This paper compares the inventive output of two science systems in small European countries. More specifically, we examine patented inventions of Finnish and Flemish university researchers. The comparison includes inventive output as such and its concentration on organizations, inventors, and corporate owners as well as foreign assignations and the degree to which individual inventors have retained the ownership of the patents. While there are commonalities between the Finnish and Flemish systems in terms of patent concentration on key institutions and corporate assignees, there are also pronounced differences with respect to the ownership structure of academic patents, which was expected in light of the different intellectual property regulations. Our observations seem to suggest that the total inventive output of a research system is not a function of the prevailing intellectual property system but rather in correspondence to overall national inventiveness thereby pointing to more general (national, cultural) drivers of academic inventive activity. From a methodological viewpoint, this research illustrates that tracing university-owned patents alone would leave considerable technological contributions of academics unidentified - also in countries where universities own the rights to their researchers patents. Another finding with potential methodological implications is that patents are highly concentrated on institutions. If such a distribution law applies to large countries as well, analysts could cover most of the national academic patent output by an intelligent selection of universities.     

Creating a Natural Vascular Scaffold by Photochemical Treatment of the Extracellular Matrix for Vascular Applications

The development of bioscaffolds for cardiovascular medical applications, such as peripheral artery disease (PAD), remains to be a challenge for tissue engineering. PAD is an increasingly common and serious cardiovascular illness characterized by progressive atherosclerotic stenosis, resulting in decreased blood perfusion to the lower extremities. Percutaneous transluminal angioplasty and stent placement are routinely performed on these patients with suboptimal outcomes. Natural Vascular Scaffolding (NVS) is a novel treatment in the development for PAD, which offers an alternative to stenting by building on the natural structural constituents in the extracellular matrix (ECM) of the blood vessel wall. During NVS treatment, blood vessels are exposed to a photoactivatable small molecule (10-8-10 Dimer) delivered locally to the vessel wall via an angioplasty balloon. When activated with 450 nm wavelength light, this therapy induces the formation of covalent protein–protein crosslinks of the ECM proteins by a photochemical mechanism, creating a natural scaffold. This therapy has the potential to reduce the need for stent placement by maintaining a larger diameter post-angioplasty and minimizing elastic recoil. Experiments were conducted to elucidate the mechanism of action of NVS, including the molecular mechanism of light activation and the impact of NVS on the ECM.