An interregional labour market model incorporating vacancy chains and social security

This paper deals with three aspects of interregional demo-economic models which are important with respect to the analysis of regional labour market developments. First, attention is paid to forecasts of the exogenous regional variables, such as investments, exports, etc. Because data at the regional level are usually scarce, it is suggested to make these projections by means of a top-down model. Second, the social security sector is incorporated in the model framework, because changes in social security benefits, which are common in many Western countries nowaday, usually have substantial impacts on regional economic and demographic structures. Third, a vacancy chain model instead of a simple employment growth equation is tied to the standard demo-economic model framework. In this way not only employment growth but also migration, job mobility and related income effects can be taken into account.     

Thixoforging of 332 aluminum alloy in a mechanical eccentric press

Journal of Materials Science - This study sought to analyze the semi-solid behavior of commercial 332 aluminum alloy during thixoforming in a mechanical eccentric press (thixoforging). The...     

Brazilian scientific production in science education

In the present study we analyzed the Brazilian scientific production in the area of science education. The study was structured on: data by research groups registered in Conselho Nacional de Desenvolvimento Científico e Tecnológico; analysis of the post-graduate strictu sensu programs; analysis of theses and dissertations linked to post-graduate programs; and papers in international databases. Our research was conducted strictly via world wide web, from December 2009 to September 2010. It was found that both number of research groups, researchers, post-graduate programs, thesis, dissertations and papers presented a marked increase, especially in the last decade (from 2000 onwards). The major research centers were found to be located in public universities from Brazilian southeast and south regions. However, it was observed a tendency of decentralization, due to a recent investment in new public universities in the other Brazilian regions. So, this study sought to present an overview of the scientific production about science education and we expect that this information can help to expand the vision about the development of this research area in Brazil.     

Polymeric Nanoparticle-Based Photodynamic Therapy for Chronic Periodontitis in Vivo

Antimicrobial photodynamic therapy (aPDT) is increasingly being explored for treatment of periodontitis. Here, we investigated the effect of aPDT on human dental plaque bacteria in suspensions and biofilms in vitro using methylene blue (MB)-loaded poly(lactic-co-glycolic) (PLGA) nanoparticles (MB-NP) and red light at 660 nm. The effect of MB-NP-based aPDT was also evaluated in a clinical pilot study with 10 adult human subjects with chronic periodontitis. Dental plaque samples from human subjects were exposed to aPDT—in planktonic and biofilm phases—with MB or MB-NP (25 µg/mL) at 20 J/cm² in vitro. Patients were treated either with ultrasonic scaling and scaling and root planing (US + SRP) or ultrasonic scaling + SRP + aPDT with MB-NP (25 µg/mL and 20 J/cm²) in a split-mouth design. In biofilms, MB-NP eliminated approximately 25% more bacteria than free MB. The clinical study demonstrated the safety of aPDT. Both groups showed similar improvements of clinical parameters one month following treatments. However, at three months ultrasonic SRP + aPDT showed a greater effect (28.82%) on gingival bleeding index (GBI) compared to ultrasonic SRP. The utilization of PLGA nanoparticles encapsulated with MB may be a promising adjunct in antimicrobial periodontal treatment.     

Carbon-Based Materials in Photodynamic and Photothermal Therapies Applied to Tumor Destruction

Within phototherapy, a grand challenge in clinical cancer treatments is to develop a simple, cost-effective, and biocompatible approach to treat this disease using ultra-low doses of light. Carbon-based materials (CBM), such as graphene oxide (GO), reduced GO (r-GO), graphene quantum dots (GQDs), and carbon dots (C-DOTs), are rapidly emerging as a new class of therapeutic materials against cancer. This review summarizes the progress made in recent years regarding the applications of CBM in photodynamic (PDT) and photothermal (PTT) therapies for tumor destruction. The current understanding of the performance of modified CBM, hybrids and composites, is also addressed. This approach seeks to achieve an enhanced antitumor action by improving and modulating the properties of CBM to treat various types of cancer. Metal oxides, organic molecules, biopolymers, therapeutic drugs, among others, have been combined with CBM to treat cancer by PDT, PTT, or synergistic therapies.     

Influence of Drying Techniques on the Characteristics of Chitosan and the Quality of Biopolymer Films

In this work, spouted bed and tray-drying techniques were employed at different drying air temperatures to produce dried chitosan, and the chitosan powder was used to produce biofilms. The products obtained from each drying technique were compared in relation to quality aspects (molecular weight, lightness, and hue angle). The results found for chitosan in spouted bed drying (90°C) showed lower alteration and best quality aspects in relation to the chitosan powder. However, in tray drying under the best condition (60°C) the chitosan molecular weight increased about 50% in relation to the initial value and browning was observed. The biofilms produced from chitosan dried in the spouted bed showed the best mechanical properties (tensile strength of 42 MPa and elongation of 29%) and lower water vapor permeability (3.95 g mm m^?2 kPa^?1 day^?1).     

W-based versus latent variables spatial autoregressive models: evidence from Monte Carlo simulations

In this paper, we compare by means of Monte Carlo simulations two approaches to take spatial autocorrelation into account: the classical spatial autoregressive model and the structural equations model with latent variables. The former accounts for spatial dependence and spillover effects in georeferenced data by means of a spatial weights matrix W. The latter represents spatial dependence and spillover effects by means of a latent variable in the structural (regression) model while the observed spatially lagged variables are related to the latent spatial dependence variable in the measurement model. The simulation results based on Anselin’s Columbus, Ohio, crime data set show that the misspecified latent variables approach slightly trails the correctly specified classical approach in terms of bias and root mean squared error of the coefficient estimators.     

Chromogenic anionic chemosensors based on protonated merocyanine solvatochromic dyes: Influence of the medium on the quantitative and naked-eye selective detection of anionic species

Three merocyanine solvatochromic dyes, Brooker's merocyanine, Reichardt's dye and 4-(2,4,6-triphenylpyridinium-1-yl)phenolate were solubilized in acetonitrile. Although solutions of each of the compounds are colored, the color disappears after protonation. Addition of various anions to solutions of the protonated dyes revealed that only CN^?, F^?, and H₂PO₄^? led to the reappearance of the original color of protonated Reichardt's dye, and only CN^? and F^? ions caused the original color of the solutions containing the other two protonated dyes to reappear. Addition of small amounts of water to solutions containing the protonated compounds made them useful only for detecting CN^? among all the other anions. A model was used to explain the experimental results, which considers proton transfer from the protonated dye to the anion through three dye:anion stoichiometries, namely 1:1, 1:2, and 1:3.     

Contraception by induction of luteinized unruptured follicles with short-acting low molecular weight FSH receptor agonists in female animal models

During recent decades minor innovative drugs have been developed for the female contraceptive market and they all contain steroidal progestagens (and estrogens) that act centrally and have side effects that can be attributed to this central action. In this study, we present an innovative tissue-specific approach for female contraception by low molecular weight (LMW) FSH receptor (FSHR) agonists, which interact with the FSHR that is dominantly expressed in the granulosa cells. The oral administration of LMW FSHR agonists with a short circulation time, induced formation of luteinized unruptured follicles (LUFs) from the Graafian follicles, thereby preventing the release of the oocyte. The short-acting LMW FSHR compounds were fully agonistic to FSHR (EC(50)=4-5 nM). In an isolated mouse follicle culture, a short incubation period (2 h) resulted in inhibition of follicular rupture, where continuous incubation induced follicle growth. Pharmacokinetics after oral administration showed a surge-like exposure in rats and monkeys. Oral administration of short-acting LMW FSHR agonists inhibited ovulation at 10 mg/kg in rats and guinea pigs by generating LUFs without affecting cyclicity. Also, inhibition of follicular rupture was shown to be reversible within one cycle. Finally, LUFs were induced without affecting the hormonal cyclicity in cynomolgus monkeys, a mono-ovulatory species. In healthy women LUF formation occurs naturally, with a LUF acting as corpus luteum that produces enough progesterone to ensure normal menstrual cyclicity. Together with the presented data this indicates that the innovative approach with short-acting LMW FSHR agonists could lead to oral contraception for females at the ovarian level.