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LeCronier DJ Papakonstantinou JS Gheevarughese V Beran CD Walter NE Atkinson PJ 《Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine》2012,226(4):330-336
Previous animal models have been developed to study intramedullary nailing for challenging segmental defects in the tibia. In large animals, interlocked nail fixation created a stable environment suitable to study new bone growth technologies placed in the defect. To our knowledge, there are no comparable interlocked tibial defect models for the rabbit in which new technologies could be evaluated. Such a model would be helpful since the rabbit is a popular initial model for orthopedic research studies owing to its wide availability and low cost. While numerous studies have nailed the rabbit tibia, all were non-locked implants that allowed some degree of instability between the fracture fragments. In addition, the non-locked nails were constructed of stainless steel, whereas human nails are increasingly made from titanium alloy. In the current study, an interlocked titanium nail was developed for the rabbit tibia. It was implanted in cadaver tibiae and subjected to fatigue cycling in combined compression and bending at physiologic levels to 21,061 cycles. This duration is estimated to represent 12 weeks of gait by the animal. Before and after fatigue cycling, monotonic testing was performed in compression and bending at physiologic levels. The intact contralateral limbs served as controls. All limbs completed the cycling; the instrumented limbs exhibited interfragmentary cyclic strain amplitudes during fatigue (616 +/- 139 micro-strain), which was significantly greater than the control limbs (136 +/- 35 microstrain). Monotonic strain amplitudes for the test limbs in bending and compression were 4839 +/- 1028 and 542 +/- 122 microstrain, respectively; corresponding values for the control bones were 407 +/- 118 and 95 +/- 38 microstrain, respectively. These data are similar to those presented in prior studies in larger bone models. The current study presents one method for interlocked nail fixation for this complex tibial shaft fracture in a small animal. 相似文献
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Yousef M. Abul‐Haija Sangita Roy Pim W. J. M. Frederix Nadeem Javid Vineetha Jayawarna Rein V. Ulijn 《Small (Weinheim an der Bergstrasse, Germany)》2014,10(5):973-979
For the development of applications and novel uses for peptide nanostructures, robust routes for their surface functionalization, that ideally do not interfere with their self‐assembly properties, are required. Many existing methods rely on covalent functionalization, where building blocks are appended with functional groups, either pre‐ or post‐assembly. A facile supramolecular approach is demonstrated for the formation of functionalized nanofibers by combining the advantages of biocatalytic self‐assembly and surfactant/gelator co‐assembly. This is achieved by enzymatically triggered reconfiguration of free flowing micellar aggregates of pre‐gelators and functional surfactants to form nanofibers that incorporate and display the surfactants’ functionality at the surface. Furthermore, by varying enzyme concentration, the gel stiffness and supramolecular organization of building blocks can be varied. 相似文献
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Vineetha Mukundan Jun Yin Pharrah Joseph Jin Luo Shiyao Shan Dmitri N Zakharov 《Science and Technology of Advanced Materials》2014,15(2)
Nanoscale alloying and phase transformations in physical mixtures of Pd and Cu ultrafine nanoparticles are investigated in real time with in situ synchrotron-based x-ray diffraction complemented by ex situ high-resolution transmission electron microscopy. The combination of metal–support interaction and reactive/non-reactive environment was found to determine the thermal evolution and ultimate structure of this binary system. At 300 °C, the nanoparticles supported on silica and carbon black intermix to form a chemically ordered CsCl-type (B2) alloy phase. The B2 phase transforms into a disordered fcc alloy at higher temperature (> 450 °C). The alloy nanoparticles supported on silica and carbon black are homogeneous in volume, but evidence was found of Pd surface enrichment. In sharp contrast, when supported on alumina, the two metals segregated at 300 °C to produce almost pure fcc Cu and Pd phases. Upon further annealing of the mixture on alumina above 600 °C, the two metals interdiffused, forming two distinct disordered alloys of compositions 30% and 90% Pd. The annealing atmosphere also plays a major role in the structural evolution of these bimetallic nanoparticles. The nanoparticles annealed in forming gas are larger than the nanoparticles annealing in helium due to reduction of the surface oxides that promotes coalescence and sintering. 相似文献
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Rao K. Srinivasa Vineetha K. V. Sailaja B. V. S. Guha Koushik Maity N. P. Maity Reshmi Sravani K. Girija 《Microsystem Technologies》2021,27(2):419-441
Microsystem Technologies - This paper presents two different types of micro channels namely one is cylindrical and the other is rectangular which are designed and simulated using FEM tool for the... 相似文献
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Rao K. Srinivasa Kumar P. Ashok Guha Koushik Sailaja B. V. S. Vineetha K. V. Baishnab K. L. Sravani K. Girija 《Microsystem Technologies》2021,27(2):455-462
Microsystem Technologies - This Paper Presents the design and simulation of RF MEMS switch taken on Microstrip patch antenna loaded with the circular type CSRR. The Tunability of the patch antenna... 相似文献
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Vineetha K. V. Madhav B. T. P. Kumar M. S. Devi Y. U. Prakash K. B. 《Journal of Communications Technology and Electronics》2022,67(4):443-455
Journal of Communications Technology and Electronics - This article explored the design and implementation of rectangular split ring resonator (SRR) based microstrip bandpass filter for mobile... 相似文献
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Rao K. Srinivasa Sailaja B. V. S. Vineetha K. V. Kumar P. Ashok Guha Koushik Sravani K. Girija 《Microsystem Technologies》2021,27(2):503-513
Microsystem Technologies - This paper deals with the study of shunt capacitive RF switches. Comparative study is done on non-uniform designed structures, which are simulated using finite element... 相似文献
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Vineetha K. V. Sravani K. Girija Sailaja B. V. S. Guha Koushik Varma P. Srinivas Rao K. Srinivasa 《Microsystem Technologies》2018,24(12):4785-4797
Microsystem Technologies - This paper presents three types of the microchannel which is used for the detection of cholera and diarrhea. The three types of microchannels are namely cylindrical,... 相似文献
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Srinivasa Rao K. Sailaja B. V. S. Kumar Akshay Vineetha K. Guha Koushik Baishanab K. L. Girija Sravani K. 《Microsystem Technologies》2020,26(10):3193-3202
Microsystem Technologies - This paper mainly focuses on the investigation of different meandering techniques for the MEMS RF shunt capacitive switch. It involves three meandering techniques for the... 相似文献