Supporting collaborative engineering design

The complexity of current engineering design demands the collaboration of specialists. Collaboration involves both communication between and coordination among members of a design team. Currently, design collaboration is carried out through the use of schedules, specifications and drawings which only capture the end results of the design process. They fail to record important design information such as the reasoning behind design decisions. In this paper, we describe a tool CADS, that supports collaboration in engineering design. CADS is based on an extension to the Axiomatic Design methodology which not only captures the design elements but also the rationale used to conceive them. CADS serves as a shared database of design information with facilities that support communication and coordination in engineering design.Currently at the Media Laboratory, MIT.     

Evidence that the modulation of membrane-associated protein kinase C activity by an endogenous inhibitor plays a role in N1E-115 murine neuroblastoma cell differentiation

Murine neuroblastoma cells, N1E-115, were induced to differentiate into neuron-like cells by serum deprivation for 18 h. As previous studies have shown that the suppression of protein kinase C (PKC) activity by selective inhibitors or neutralizing antibodies induces neuroblastoma cells to differentiate, we tested the hypothesis that serum deprivation may cause a rapid loss in membrane PKC activity that occurs well before the morphological changes that are characteristic of cell differentiation. A significant reduction in particulate (membrane) PKC activity was indeed observed within 3 h of serum withdrawal when enzyme activity was measured in intact native membranes by the recently described in vitro "direct" assay. This rapid reduction in enzyme activity was confirmed by the decreased phosphorylation of the MARCKS protein, an endogenous PKC-selective substrate, in intact cells. The decrease in membrane PKC activity occurred without any loss in the amount of membrane-associated enzyme, suggesting that some factor(s) resident in neuroblastoma membranes was suppressing PKC activity. Indeed, results indicate the presence of an endogenous inhibitor of PKC tightly associated with neuroblastoma membranes. This inhibitory activity increased in the membranes of cells subjected to serum deprivation, raising the possibility that it was likely responsible for the decline in membrane PKC activity in differentiating N1E-115 cells. Preliminary characterization indicated that the inhibitory activity is a protein and is localized mainly in the membrane fraction. Thus, these results demonstrate directly that endogenous inhibitor can regulate membrane-associated PKC activity in cells and thereby modulate PKC-related neuronal functions.     

Analysis of temporal jitter in a copper vapor laser system

Temporal jitter in a magnetic pulse compression based copper vapor laser (CVL) system is analyzed by considering ripple present in the input dc power supply and ripple present in the magnetic core resetting power supply. It is shown that the jitter is a function of the ratio of operating voltage to the designed voltage, percentage ripple, and the total propagation delay of the magnetic pulse compression circuit. Experimental results from a CVL system operating at a repetition rate of 9 kHz are presented.     

Applications of 'TissueQuant'- a color intensity quantification tool for medical research

This paper demonstrates the use of TissueQuant - an image analysis tool for quantification of color intensities which was developed for use in medical research where the stained biological specimen such as tissue or antigen needs to be quantified. TissueQuant provides facilities for user interaction to choose and quantify the color of interest and its shades. Gaussian weighting functions are used to provide a color score which quantifies how close the shade is to the user specified reference color. We describe two studies in medical research which use TissueQuant for quantification. The first study evaluated the effect of petroleum-ether extract of Cissus quadrangularis (CQ) on osteoporotic rats. It was found that the analysis results correlated well with the manual evaluation, p < 0.001. The second study evaluated the nerve morphometry and it was found that the adipose and non adipose tissue content was maximum in radial nerve among the five nerves studied.     

Effects of Microbial Polysaccharides on the Oil Absorption and Quality Characteristics of a Deep-Fried Snack Namkeen

This study investigates the potential of microbial polysaccharides (MP) gellan gum and pullulan to reduce oil uptake in a deep-fried snack (Namkeen). The concentration of MP in refined wheat flour varied between 1–10% (w/w) and the frying time and temperature are optimized. The results reveal that MP added namkeens showed a maximum relative oil reduction of 33.87% with gellan gum and 26.93% with pullulan at 10% (w/w). Gellan gum and pullulan result in oil reduction of 23.19% and 15.97% with 5% (w/w). The results reveal that gellan gum added namkeens exhibited 1.45 times lower oil uptake than pullulan added namkeen indicating potential oil reduction capabilities. The hardness of namkeen is observed to increase with an increase in MP concentration. Sensorial and textural characteristics of control and MP incorporated fried samples are comparable up to 5% (w/w) with MP concentration. The results for the control samples and MP incorporated samples are statistically significant. Furthermore, overall sensorial acceptability of pullulan added namkeens (7.74 ± 0.53) is slightly higher than that of gellan gum added namkeens (7.64 ± 0.36). Practical Application: Low-fat diet and functional foods are expected to help in managing the conditions of hyperlipidaemia. This study focuses on the potential of MP in reducing the oil content of deep-fried snacks. The efficacy of MP gellan gum and pullulan as functional ingredients for oil reduction in fried snacks demonstrates its aid in formulating low-fat foods thereby retaining sensorial characteristics.     

Sustainable Drilling of Nano SiC Reinforced Al Matrix Composites Using MQL and Cryogenic Cooling for Achieving the Better Surface Integrity

Silicon - Metal Matrix Nano Composites (MMNCs) are progressive alternatives of formal metal materials, are presently accomplishing a growing inclination of research and engineering approaches for...     

A Multidigit Adaptive Delta Modulation (ADM) System

A multidigit adaptive delta modulation (ADM) system has been proposed where the error signal, between the input and the approximated signal produced by ADM coder, is coded in an auxiliary encoder. The error in the auxiliary coder is processed by another ADM and so on. The bit rate of each of these coders isf_{r}/Nwhere fris the overall transmission rate andNis the number of coders used. The bit streams are interleaved for transmission and at the receiver they are separated and decoded, and these signals are added and filtered. It is shown that for a given transmission rate, each coder operates at a basic sampling rate of frBsuch thatN_{opt} = f_{r}/f_{rB}gives the optimum number of coders to be used for maximum signal-to-noise ratio (SNR). A bound is derived for the maximum SNR of such a system and is compared with the bounds derived for other predictive coders. The experimental results of a two-digit ADM are presented. An average SNR of 30 dB is obtained with a dynamic range of 32 dB at fr= 32 kbits/s for band-limited noise signals. The SNR increases with the sampling rate at 15 dB/octave, as against 9 dB for a single-digit ADM. The frequency response is good and the variation of SNR with the message frequency of the delta coding system has been improved. The effect of channel errors has also been studied and the performance of the system is found satisfactory.     

Applications of Polymer Matrix Syntactic Foams

A collection of applications of polymer matrix syntactic foams is presented in this article. Syntactic foams are lightweight porous composites that found their early applications in marine structures due to their naturally buoyant behavior and low moisture absorption. Their light weight has been beneficial in weight sensitive aerospace structures. Syntactic foams have pushed the performance boundaries for composites and have enabled the development of vehicles for traveling to the deepest parts of the ocean and to other planets. The high volume fraction of porosity in syntactic foams also enabled their applications in thermal insulation of pipelines in oil and gas industry. The possibility of tailoring the mechanical and thermal properties of syntactic foams through a combination of material selection, hollow particle volume fraction, and hollow particle wall thickness has helped in rapidly growing these applications. The low coefficient of thermal expansion and dimensional stability at high temperatures are now leading their use in electronic packaging, composite tooling, and thermoforming plug assists. Methods have been developed to tailor the mechanical and thermal properties of syntactic foams independent of each other over a wide range, which is a significant advantage over other traditional particulate and fibrous composites.     

Development of solid state pulse power modulator using toroidal amorphous core

This paper discusses the experiments conducted for the development of 50 kV, 10 A, 10 μs duration, and rise time of 2 μs solid state pulse power modulator using toroidal amorphous steel core and low cost IGBT switches. The experiments revealed (i) the need for new design methodologies based on energy transfer between the electrical and magnetic systems and (ii) the success of low-cost switching circuit.