Multifractal analysis of non-conformal repellers: a model case

For a model class of repellers of non-conformal expanding maps, we obtain sharp lower bounds for the dimension spectra of the Birkhoff averages of a Hölder continuous function. As in the well-studied case of conformal dynamics, the bounds are also expressed here in terms of the thermodynamic formalism.     

X-ray Fluorescence Uptake Measurement of Functionalized Gold Nanoparticles in Tumor Cell Microsamples

Quantitative cellular in vitro nanoparticle uptake measurements are possible with a large number of different techniques, however, all have their respective restrictions. Here, we demonstrate the application of synchrotron-based X-ray fluorescence imaging (XFI) on prostate tumor cells, which have internalized differently functionalized gold nanoparticles. Total nanoparticle uptake on the order of a few hundred picograms could be conveniently observed with microsamples consisting of only a few hundreds of cells. A comparison with mass spectroscopy quantification is provided, experimental results are both supported and sensitivity limits of this XFI approach extrapolated by Monte-Carlo simulations, yielding a minimum detectable nanoparticle mass of just 5 pg. This study demonstrates the high sensitivity level of XFI, allowing non-destructive uptake measurements with very small microsamples within just seconds of irradiation time.     

New method for identifying finite degree Volterra series

In this paper, the identification of a class of nonlinear systems which admits input-output maps described by a finite degree Volterra series is considered. In actual fact, it appears that this class can model many important nonlinear multivariable processes not only in engineering, but also in biology, socio-economics, and ecology.To solve this identification problem, we propose a method based on local gradient search in a local parameterization of the state-space realization of finite degree Volterra series with infinite horizon. Using the local parameterization not only reduces the amount of the gradient calculations to the minimal value, but also overcomes the nonuniqueness problem of the optimal solution.Moreover, we propose a sequential projection method to provide an initial estimation of the parameters of finite degree Volterra series realization. This initial estimation is used to initialize the gradient search method.     

Minimizing the total completion time in a two-machine flowshop problem with time delays

This article proposes to solve the problem of minimizing the total completion time in a two-machine permutation flowshop environment in which time delays between the machines are considered. For this purpose, an enumeration algorithm based on the branch-and-bound framework is developed, which includes new lower and upper bounds as well as dominance rules. The computational study shows that problems with up to 40 jobs can be solved in a reasonable amount of time.     

Potential of near-field microwave imaging in breast cancer detection utilizing tapered rectangular waveguide probes

Microwave imaging for medical applications has been of interest for many years. A novel near-field microwave non-invasive testing and evaluation (NIT&E) technique utilizing tapered rectangular waveguide probes is presented for breast cancer detection. Near-field microwave NIT&E techniques can be a successful candidate for the detection of breast cancer because of their potential in dealing with materials of low conductivity (i.e. lossy dielectrics like the breast tissue). The physical basis for breast tumor detection with microwave imaging is the contrast in dielectric properties of normal and malignant breast tissues. A method adopting Fourier transform matching (FTM) technique and utilizing the reflection coefficient at the aperture of a tapered rectangular waveguide sensor radiating into a breast is described resulting in microwave images that indicate the presence of a tumor. These images demonstrate the feasibility of detecting breast tumors using this approach.     

Adaptive ROC-based ensembles of HMMs applied to anomaly detection

Hidden Markov models (HMMs) have been successfully applied in many intrusion detection applications, including anomaly detection from sequences of operating system calls. In practice, anomaly detection systems (ADSs) based on HMMs typically generate false alarms because they are designed using limited amount of representative training data. Since new data may become available over time, an important feature of an ADS is the ability to accommodate newly acquired data incrementally, after it has originally been trained and deployed for operations. In this paper, a system based on the receiver operating characteristic (ROC) is proposed to efficiently adapt ensembles of HMMs (EoHMMs) in response to new data, according to a learn-and-combine approach. When a new block of training data becomes available, a pool of base HMMs is generated from the data using a different number of HMM states and random initializations. The responses from the newly trained HMMs are then combined to those of the previously trained HMMs in ROC space using a novel incremental Boolean combination (incrBC) technique. Finally, specialized algorithms for model management allow to select a diversified EoHMM from the pool, and adapt Boolean fusion functions and thresholds for improved performance, while it prunes redundant base HMMs. The proposed system is capable of changing the desired operating point during operations, and this point can be adjusted to changes in prior probabilities and costs of errors. Computer simulations conducted on synthetic and real-world host-based intrusion detection data indicate that the proposed system can achieve a significantly higher level of performance than when parameters of a single best HMM are estimated, at each learning stage, using reference batch and incremental learning techniques. It also outperforms the learn-and-combine approaches using static fusion functions (e.g., majority voting). Over time, the proposed ensemble selection algorithms form compact EoHMMs, while maintaining or improving system accuracy. Pruning allows to limit the pool size from increasing indefinitely, thereby reducing the storage space for accommodating HMMs parameters without negatively affecting the overall EoHMM performance. Although applied for HMM-based ADSs, the proposed approach is general and can be employed for a wide range of classifiers and detection applications.     

Behavior of Composite Unreinforced Masonry–Fiber-Reinforced Polymer Wall Assemblages Under In-Plane Loading

An experimental investigation was conducted to study the in-plane behavior of face shell mortar bedded unreinforced masonry (URM) wall assemblages retrofitted with fiber-reinforced polymer (FRP) laminates. Forty-two URM assemblages were tested under different stress conditions present in masonry shear and infill walls. Tests included prisms loaded in compression with different bed joint orientation (on/off-axis compression), diagonal tension specimens, and specimens loaded under joint shear. The behavior of each specimen type is discussed with emphasis on modes of failure, strength and deformation characteristics. Results showed that the application of FRP laminates on URM has a great influence on strength, postpeak behavior, as well as altering failure modes and maintaining the specimen integrity. The retrofitted specimens reached compressive strength of 1.62–5.64 times that of their unretrofitted counterparts, depending on the bed joint orientation, and joint shear strength increased by eightfold.     

The pleural thickening approximation from thoracic CT scans

Multimedia Tools and Applications - The involvement of medical imaging in medical procedures plays an important role in the diagnosis and planning of a therapeutic treatment. Computerized...     

Genomics and Epigenomics of Gestational Diabetes Mellitus: Understanding the Molecular Pathways of the Disease Pathogenesis

One of the most common complications during pregnancy is gestational diabetes mellitus (GDM), hyperglycemia that occurs for the first time during pregnancy. The condition is multifactorial, caused by an interaction between genetic, epigenetic, and environmental factors. However, the underlying mechanisms responsible for its pathogenesis remain elusive. Moreover, in contrast to several common metabolic disorders, molecular research in GDM is lagging. It is important to recognize that GDM is still commonly diagnosed during the second trimester of pregnancy using the oral glucose tolerance test (OGGT), at a time when both a fetal and maternal pathophysiology is already present, demonstrating the increased blood glucose levels associated with exacerbated insulin resistance. Therefore, early detection of metabolic changes and associated epigenetic and genetic factors that can lead to an improved prediction of adverse pregnancy outcomes and future cardio-metabolic pathologies in GDM women and their children is imperative. Several genomic and epigenetic approaches have been used to identify the genes, genetic variants, metabolic pathways, and epigenetic modifications involved in GDM to determine its etiology. In this article, we explore these factors as well as how their functional effects may contribute to immediate and future pathologies in women with GDM and their offspring from birth to adulthood. We also discuss how these approaches contribute to the changes in different molecular pathways that contribute to the GDM pathogenesis, with a special focus on the development of insulin resistance.